Topical administration of a marine oil rich in pro-resolving lipid mediators accelerates wound healing in diabetic db/db mice through angiogenesis and macrophage polarization

Impaired wound healing in patients with type 2 diabetes (DM2) is characterized by chronic inflammation, which delays wound closure. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules produced from essential polyunsaturated fatty acids (PUFAs), principally omega-3 docosahexaenoi...

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Detalles Bibliográficos
Autores: Ontoria-Oviedo, I. (Imelda)|||/items/194de620-b8a7-4809-bb7f-a4a54fb90c39, Amaro-Prellezo, E. (Elena)|||/items/7821772b-7239-46ea-8c2c-a871967f1bf1, Castellano, D. (Delia)|||/items/96674521-b7a6-4921-9f77-a0cb209ea242, Venegas-Venegas, E. (Elena)|||/items/b9e707b6-e2cf-4a49-b2de-f5c751523212, González-Santos, F. (Fernando)|||/items/0be7afbe-acbc-4adc-a0ca-afc9ac77ef5e, Ruiz-Saurí, A. (Amparo)|||/items/694049aa-97e7-4305-b95f-788fab90da05, Pelacho-Samper, B. (Beatriz)|||/items/aca35c0e-183d-435d-9d44-1888e0854ff3, Prosper-Cardoso, F. (Felipe)|||/items/3d1b0b82-06c3-4e63-8280-e903dc4dc0c1, Pérez-del-Caz, M.D. (María Dolores)|||/items/0cb1e092-dfca-4164-8e8c-459cbd838551, Sepúlveda, P. (Pilar)|||/items/6812bc9d-bb9a-4561-89bc-40e4434b0799
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dnet:dadun_______::df341233d7debaeb018c98ae094a2102
Acceso en línea:https://hdl.handle.net/10171/124123
Access Level:acceso abierto
Palabra clave:SPMs
Angiogenesis
Diabetic ulcer
Macrophage polarization
Omega-3
Pro-resolving lipid mediators
Wound healing
Descripción
Sumario:Impaired wound healing in patients with type 2 diabetes (DM2) is characterized by chronic inflammation, which delays wound closure. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules produced from essential polyunsaturated fatty acids (PUFAs), principally omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). SPMs are potent regulators of inflammation and have been used to suppress chronic inflammation in peripheral artery disease, non-alcoholic fatty liver disease, and central nervous system syndromes. LIPINOVA® is a commercially available safe-grade nutritional supplement made from a fractionated marine lipid concentrate derived from anchovy and sardine oil that is rich in SPMs and EPA, as well as DHA precursors. Here, we assessed the effect of LIPINOVA® in wound dressing applications. LIPINOVA® showed biocompatibility with keratinocytes and fibroblasts, reduced the abundance of pro-inflammatory macrophages (Mφ1), and promoted in vitro wound closure. Daily application of the marine oil to open wounds made by punch biopsy in db/db mice promoted wound closure by accelerating the resolution of inflammation, inducing neoangiogenesis and Mφ1/Mφ2 macrophage polarization. In conclusion, LIPINOVA® displays pro-resolutive properties and could be exploited as a therapeutic agent for the treatment of diabetic ulcers.

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