E14a2 Transcript Favors Treatment-Free Remission in Chronic Myeloid Leukemia When Associated with Longer Treatment with Tyrosine Kinase Inhibitors and Sustained Deep Molecular Response

e13a2 and e14a2 are the most frequent transcript types of the BCR::ABL1 fusion gene in chronic myeloid leukemia (CML). The current goal with tyrosine kinase inhibitors (TKI) is to achieve sustained deep molecular response (DMR) in order to discontinue TKI treatment and remain in the so-called treatm...

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Detalles Bibliográficos
Autores: Marcé, Sílvia, Méndez, Aleix, Xicoy, Blanca, Estrada, Natalia, Cabezón, Marta, Sturla, Antonella Luciana, Ratia García, Miriam, Angona, Anna, Amat, Paula, Escribano Serrat, Silvia, Scalzulli, Emilia, Morgades, Mireia, Senín, Alicia, Hernández Boluda, Juan Carlos, Ferrer Marín, Francisca, Anguita, Eduardo, Cortés, Montserrat, Plensa, Esther, Breccia, Massimo, García Gutiérrez, Valentín, Zamora, Lurdes
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/208393
Acceso en línea:https://hdl.handle.net/2445/208393
Access Level:acceso abierto
Palabra clave:Leucèmia mieloide
Inhibidors enzimàtics
Myeloid leukemia
Enzyme inhibitors
Descripción
Sumario:e13a2 and e14a2 are the most frequent transcript types of the BCR::ABL1 fusion gene in chronic myeloid leukemia (CML). The current goal with tyrosine kinase inhibitors (TKI) is to achieve sustained deep molecular response (DMR) in order to discontinue TKI treatment and remain in the so-called treatment-free remission (TFR) phase, but biological factors associated with these goals are not well established. This study aimed to determine the effect of transcript type on TFR in patients receiving frontline treatment with imatinib (IM) or second-generation TKI (2G-TKI). Patients treated at least 119 months with IM presented less post-discontinuation relapse than those that discontinued IM before 119 months (p = 0.005). In addition, cases with the e14a2 transcript type treated at least 119 months with IM presented a better TFR (p = 0.024). On the other hand, the type of transcript did not affect the cytogenetic or molecular response in 2G-TKI treated patients; however, the use of 2G-TKI may be associated with higher and earlier DMR in patients with the e14a2 transcript.

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