The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease

The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–threonine kinases that have been implicated in DNA replication, DNA repair, transcription, chromatin structure, viral latency, cell cycle checkpoint control and chromosomal stability in various organisms. The functions...

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Authors: Segura Bayona, Sandra, Stracker, Travis H.
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/140778
Online Access:https://hdl.handle.net/2445/140778
Access Level:Open access
Keyword:Proteïnes quinases
ADN
Protein kinases
DNA
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spelling The Tousled-like kinases regulate genome and epigenome stability: implications in development and diseaseSegura Bayona, SandraStracker, Travis H.Proteïnes quinasesADNProtein kinasesDNAThe Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–threonine kinases that have been implicated in DNA replication, DNA repair, transcription, chromatin structure, viral latency, cell cycle checkpoint control and chromosomal stability in various organisms. The functions of the TLKs appear to depend largely on their ability to regulate the H3/H4 histone chaperone ASF1, although numerous TLK substrates have been proposed. Over the last few years, a clearer picture of TLK function has emerged through the identification of new partners, the definition of specific roles in development and the elucidation of their structural and biochemical properties. In addition, the TLKs have been clearly linked to human disease; both TLK1 and TLK2 are frequently amplified in human cancers and TLK2 mutations have been identified in patients with neurodevelopmental disorders characterized by intellectual disability (ID), autism spectrum disorder (ASD) and microcephaly. A better understanding of the substrates, regulation and diverse roles of the TLKs is needed to understand their functions in neurodevelopment and determine if they are viable targets for cancer therapy. In this review, we will summarize current knowledge of TLK biology and its potential implications in developmentSpringer Nature2019202020192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion28 p.application/pdfhttps://hdl.handle.net/2445/140778Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: http://dx.doi.org/10.1007/s00018-019-03208-zCellular and Molecular Life Science, 2019, vol. 76, num. 19, p. 3827-3841http://dx.doi.org/10.1007/s00018-019-03208-z(c) Springer Nature Switzerland AG, 2019info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1407782026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
title The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
spellingShingle The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
Segura Bayona, Sandra
Proteïnes quinases
ADN
Protein kinases
DNA
title_short The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
title_full The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
title_fullStr The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
title_full_unstemmed The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
title_sort The Tousled-like kinases regulate genome and epigenome stability: implications in development and disease
dc.creator.none.fl_str_mv Segura Bayona, Sandra
Stracker, Travis H.
author Segura Bayona, Sandra
author_facet Segura Bayona, Sandra
Stracker, Travis H.
author_role author
author2 Stracker, Travis H.
author2_role author
dc.subject.none.fl_str_mv Proteïnes quinases
ADN
Protein kinases
DNA
topic Proteïnes quinases
ADN
Protein kinases
DNA
description The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–threonine kinases that have been implicated in DNA replication, DNA repair, transcription, chromatin structure, viral latency, cell cycle checkpoint control and chromosomal stability in various organisms. The functions of the TLKs appear to depend largely on their ability to regulate the H3/H4 histone chaperone ASF1, although numerous TLK substrates have been proposed. Over the last few years, a clearer picture of TLK function has emerged through the identification of new partners, the definition of specific roles in development and the elucidation of their structural and biochemical properties. In addition, the TLKs have been clearly linked to human disease; both TLK1 and TLK2 are frequently amplified in human cancers and TLK2 mutations have been identified in patients with neurodevelopmental disorders characterized by intellectual disability (ID), autism spectrum disorder (ASD) and microcephaly. A better understanding of the substrates, regulation and diverse roles of the TLKs is needed to understand their functions in neurodevelopment and determine if they are viable targets for cancer therapy. In this review, we will summarize current knowledge of TLK biology and its potential implications in development
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140778
url https://hdl.handle.net/2445/140778
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1007/s00018-019-03208-z
Cellular and Molecular Life Science, 2019, vol. 76, num. 19, p. 3827-3841
http://dx.doi.org/10.1007/s00018-019-03208-z
dc.rights.none.fl_str_mv (c) Springer Nature Switzerland AG, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Nature Switzerland AG, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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