Antidepressant medication treatment patterns in Asian patients with major depressive disorder

PURPOSE: To describe pharmacological treatment patterns in Asian patients with major depressive disorder (MDD), including duration of treatment, reasons for medication discontinuation, rate of medication nonadherence, factors associated with medication nonadherence, and impact of medication nonadher...

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Autores: Novick, Diego, Montgomery, William, Moneta, Maria Victoria, Peng, Xiaomei, Brugnoli, Roberto, Haro Abad, Josep Maria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/103582
Acesso em linha:https://hdl.handle.net/2445/103582
Access Level:acceso abierto
Palavra-chave:Antidepressius
Farmacologia
Depressió psíquica
Assistència psiquiàtrica
Orient Mitjà
Antidepressants
Pharmacology
Mental depression
Mental health services
Middle East
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spelling Antidepressant medication treatment patterns in Asian patients with major depressive disorderNovick, DiegoMontgomery, WilliamMoneta, Maria VictoriaPeng, XiaomeiBrugnoli, RobertoHaro Abad, Josep MariaAntidepressiusFarmacologiaDepressió psíquicaAssistència psiquiàtricaOrient MitjàAntidepressantsPharmacologyMental depressionMental health servicesMiddle EastPURPOSE: To describe pharmacological treatment patterns in Asian patients with major depressive disorder (MDD), including duration of treatment, reasons for medication discontinuation, rate of medication nonadherence, factors associated with medication nonadherence, and impact of medication nonadherence on depression outcomes. PATIENTS AND METHODS: Data were from a prospective, observational 3-month study of East Asian MDD inpatients from 40 sites in six East Asian countries who initiated antidepressant treatment at baseline (n=569). Assessments included the Clinical Global Impression-Severity scale (CGI-S), 17-item Hamilton Depression Rating Scale (HAMD-17), painful physical symptoms, response and remission, employment status, quality of life (QoL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) and health state using the visual analog scale, adherence by clinician opinion, and patient self-report. Cox proportional hazards modeling, Kaplan-Meier survival analysis, and regression modeling were employed. RESULTS: Median time to discontinuation for any reason was 70 days (95% confidence interval: 47; 95). Reasons for discontinuation were inadequate response in 64.1%, nonadherence in 6.2%, and adverse events in 4.1%; 25.6% who discontinued experienced an adequate response to treatment. In those patients who had an adequate response, age and country were significantly associated with time to medication discontinuation. Patient-reported nonadherence was 57.5% and clinician-reported nonadherence was 14.6% (62/426). At 3 months, nonadherent patients had significantly higher disease severity (CGI-S, P=0.0001; HAMD-17, P<0.0001), lower QoL ratings (EQ-5D tariff, P=0.0007; EQ-5D visual analog scale, P=0.0024), and lower response and remission rates (both P<0.0001) compared with adherent patients. The odds of response and remission were greater among adherent patients. CONCLUSION: Early discontinuation of antidepressants among Asian MDD patients was high. A total of 25.6% who discontinued prematurely were experiencing an adequate response to treatment. Nonadherent patients had significantly higher disease severity, lower QoL ratings, and lower response and remission rates compared with adherent patients.Dove Medical Press2016201620152016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/103582Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/PPA.S68432Patient Preference And Adherence, 2015, vol. 9, p. 421-428https://doi.org/10.2147/PPA.S68432cc-by-nc (c) Novick, Diego et al., 2015http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1035822026-05-29T05:05:01Z
dc.title.none.fl_str_mv Antidepressant medication treatment patterns in Asian patients with major depressive disorder
title Antidepressant medication treatment patterns in Asian patients with major depressive disorder
spellingShingle Antidepressant medication treatment patterns in Asian patients with major depressive disorder
Novick, Diego
Antidepressius
Farmacologia
Depressió psíquica
Assistència psiquiàtrica
Orient Mitjà
Antidepressants
Pharmacology
Mental depression
Mental health services
Middle East
title_short Antidepressant medication treatment patterns in Asian patients with major depressive disorder
title_full Antidepressant medication treatment patterns in Asian patients with major depressive disorder
title_fullStr Antidepressant medication treatment patterns in Asian patients with major depressive disorder
title_full_unstemmed Antidepressant medication treatment patterns in Asian patients with major depressive disorder
title_sort Antidepressant medication treatment patterns in Asian patients with major depressive disorder
dc.creator.none.fl_str_mv Novick, Diego
Montgomery, William
Moneta, Maria Victoria
Peng, Xiaomei
Brugnoli, Roberto
Haro Abad, Josep Maria
author Novick, Diego
author_facet Novick, Diego
Montgomery, William
Moneta, Maria Victoria
Peng, Xiaomei
Brugnoli, Roberto
Haro Abad, Josep Maria
author_role author
author2 Montgomery, William
Moneta, Maria Victoria
Peng, Xiaomei
Brugnoli, Roberto
Haro Abad, Josep Maria
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antidepressius
Farmacologia
Depressió psíquica
Assistència psiquiàtrica
Orient Mitjà
Antidepressants
Pharmacology
Mental depression
Mental health services
Middle East
topic Antidepressius
Farmacologia
Depressió psíquica
Assistència psiquiàtrica
Orient Mitjà
Antidepressants
Pharmacology
Mental depression
Mental health services
Middle East
description PURPOSE: To describe pharmacological treatment patterns in Asian patients with major depressive disorder (MDD), including duration of treatment, reasons for medication discontinuation, rate of medication nonadherence, factors associated with medication nonadherence, and impact of medication nonadherence on depression outcomes. PATIENTS AND METHODS: Data were from a prospective, observational 3-month study of East Asian MDD inpatients from 40 sites in six East Asian countries who initiated antidepressant treatment at baseline (n=569). Assessments included the Clinical Global Impression-Severity scale (CGI-S), 17-item Hamilton Depression Rating Scale (HAMD-17), painful physical symptoms, response and remission, employment status, quality of life (QoL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) and health state using the visual analog scale, adherence by clinician opinion, and patient self-report. Cox proportional hazards modeling, Kaplan-Meier survival analysis, and regression modeling were employed. RESULTS: Median time to discontinuation for any reason was 70 days (95% confidence interval: 47; 95). Reasons for discontinuation were inadequate response in 64.1%, nonadherence in 6.2%, and adverse events in 4.1%; 25.6% who discontinued experienced an adequate response to treatment. In those patients who had an adequate response, age and country were significantly associated with time to medication discontinuation. Patient-reported nonadherence was 57.5% and clinician-reported nonadherence was 14.6% (62/426). At 3 months, nonadherent patients had significantly higher disease severity (CGI-S, P=0.0001; HAMD-17, P<0.0001), lower QoL ratings (EQ-5D tariff, P=0.0007; EQ-5D visual analog scale, P=0.0024), and lower response and remission rates (both P<0.0001) compared with adherent patients. The odds of response and remission were greater among adherent patients. CONCLUSION: Early discontinuation of antidepressants among Asian MDD patients was high. A total of 25.6% who discontinued prematurely were experiencing an adequate response to treatment. Nonadherent patients had significantly higher disease severity, lower QoL ratings, and lower response and remission rates compared with adherent patients.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/103582
url https://hdl.handle.net/2445/103582
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/PPA.S68432
Patient Preference And Adherence, 2015, vol. 9, p. 421-428
https://doi.org/10.2147/PPA.S68432
dc.rights.none.fl_str_mv cc-by-nc (c) Novick, Diego et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Novick, Diego et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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