Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease

Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthr...

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Autores: López-Jiménez, Elena, González-Aguilera, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/283043
Acceso en línea:http://hdl.handle.net/10261/283043
Access Level:acceso abierto
Palabra clave:Chromatin replication
Chromatin organization
Cell identity
Transcription regulation
Parental histone recycling
Epigenetic maintenance
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spelling Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and DiseaseLópez-Jiménez, ElenaGonzález-Aguilera, CristinaChromatin replicationChromatin organizationCell identityTranscription regulationParental histone recyclingEpigenetic maintenanceChromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.This work is part of the project PID2019-105742GA-100 funded by the MCIN/AEI/10.13039/ 501100011033. Research in the laboratory of C.G.-A. was also funded by the VI PPIT from University of Sevilla. C.G.-A. was recipient of a Ramón y Cajal contract (RYC2018-025485-I) funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”.Molecular Diversity Preservation InternationalMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Universidad de SevillaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/283043reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//PID2019-105742GA-100info:eu-repo/grantAgreement/AEI//RYC2018-025485-Ihttp://dx.doi.org/10.3390/genes13061002Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2830432026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
title Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
spellingShingle Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
López-Jiménez, Elena
Chromatin replication
Chromatin organization
Cell identity
Transcription regulation
Parental histone recycling
Epigenetic maintenance
title_short Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
title_full Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
title_fullStr Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
title_full_unstemmed Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
title_sort Role of Chromatin Replication in Transcriptional Plasticity, Cell Differentiation and Disease
dc.creator.none.fl_str_mv López-Jiménez, Elena
González-Aguilera, Cristina
author López-Jiménez, Elena
author_facet López-Jiménez, Elena
González-Aguilera, Cristina
author_role author
author2 González-Aguilera, Cristina
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Universidad de Sevilla
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Chromatin replication
Chromatin organization
Cell identity
Transcription regulation
Parental histone recycling
Epigenetic maintenance
topic Chromatin replication
Chromatin organization
Cell identity
Transcription regulation
Parental histone recycling
Epigenetic maintenance
description Chromatin organization is essential to maintain a correct regulation of gene expression and establish cell identity. However, during cell division, the replication of the genetic material produces a global disorganization of chromatin structure. In this paper, we describe the new scientific breakthroughs that have revealed the nature of the post-replicative chromatin and the mechanisms that facilitate its restoration. Moreover, we highlight the implications of these chromatin alterations in gene expression control and their impact on key biological processes, such as cell differentiation, cell reprogramming or human diseases linked to cell proliferation, such as cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/283043
url http://hdl.handle.net/10261/283043
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//PID2019-105742GA-100
info:eu-repo/grantAgreement/AEI//RYC2018-025485-I
http://dx.doi.org/10.3390/genes13061002
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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