A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population

Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities asso...

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Authors: Peypoch, Olga|||0000-0002-9795-5553, Calsina Juscafresa, Laura, Vega-Méndez, Antón, Lobato-Delgado, Bárbara|||0000-0001-6218-5774, Fité, Joan|||0000-0001-7820-6509, Soto, Begoña|||0000-0002-5965-1292, Nieto Fernández, Lluís, de la Rosa Estadella, Mireia|||0000-0002-1384-4590, Uribezubia, Ager, Romero, Jose-María, Plana, Emma|||0000-0002-8457-6984, Miralles Hernández, Manuel|||0000-0001-8340-8172, Clará Velasco, Alberto, Dilmé, Jaume|||0000-0003-0127-0064, Soria Fernández, José Manuel|||0000-0002-6226-4293, Camacho, Mercedes|||0000-0001-5970-3294, Martinez-Perez, Angel|||0000-0002-5934-1454, Sabater-Lleal, Maria|||0000-0002-0128-379X
Format: article
Publication Date:2025
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:319831
Online Access:https://ddd.uab.cat/record/319831
https://dx.doi.org/urn:doi:10.3390/jcm14134720
Access Level:Open access
Keyword:Abdominal Aortic Aneurysm (AAA)
Risk prediction models
AAA screening
Risk factors
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spelling A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish PopulationPeypoch, Olga|||0000-0002-9795-5553Calsina Juscafresa, LauraVega-Méndez, AntónLobato-Delgado, Bárbara|||0000-0001-6218-5774Fité, Joan|||0000-0001-7820-6509Soto, Begoña|||0000-0002-5965-1292Nieto Fernández, Lluísde la Rosa Estadella, Mireia|||0000-0002-1384-4590Uribezubia, AgerRomero, Jose-MaríaPlana, Emma|||0000-0002-8457-6984Miralles Hernández, Manuel|||0000-0001-8340-8172Clará Velasco, AlbertoDilmé, Jaume|||0000-0003-0127-0064Soria Fernández, José Manuel|||0000-0002-6226-4293Camacho, Mercedes|||0000-0001-5970-3294Martinez-Perez, Angel|||0000-0002-5934-1454Sabater-Lleal, Maria|||0000-0002-0128-379XAbdominal Aortic Aneurysm (AAA)Risk prediction modelsAAA screeningRisk factorsObjective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/319831https://dx.doi.org/urn:doi:10.3390/jcm14134720reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-109844RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-149864OB-I00Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII22/00007open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3198312026-06-06T12:50:31Z
dc.title.none.fl_str_mv A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
spellingShingle A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
Peypoch, Olga|||0000-0002-9795-5553
Abdominal Aortic Aneurysm (AAA)
Risk prediction models
AAA screening
Risk factors
title_short A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_full A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_fullStr A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_full_unstemmed A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
title_sort A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
dc.creator.none.fl_str_mv Peypoch, Olga|||0000-0002-9795-5553
Calsina Juscafresa, Laura
Vega-Méndez, Antón
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Fité, Joan|||0000-0001-7820-6509
Soto, Begoña|||0000-0002-5965-1292
Nieto Fernández, Lluís
de la Rosa Estadella, Mireia|||0000-0002-1384-4590
Uribezubia, Ager
Romero, Jose-María
Plana, Emma|||0000-0002-8457-6984
Miralles Hernández, Manuel|||0000-0001-8340-8172
Clará Velasco, Alberto
Dilmé, Jaume|||0000-0003-0127-0064
Soria Fernández, José Manuel|||0000-0002-6226-4293
Camacho, Mercedes|||0000-0001-5970-3294
Martinez-Perez, Angel|||0000-0002-5934-1454
Sabater-Lleal, Maria|||0000-0002-0128-379X
author Peypoch, Olga|||0000-0002-9795-5553
author_facet Peypoch, Olga|||0000-0002-9795-5553
Calsina Juscafresa, Laura
Vega-Méndez, Antón
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Fité, Joan|||0000-0001-7820-6509
Soto, Begoña|||0000-0002-5965-1292
Nieto Fernández, Lluís
de la Rosa Estadella, Mireia|||0000-0002-1384-4590
Uribezubia, Ager
Romero, Jose-María
Plana, Emma|||0000-0002-8457-6984
Miralles Hernández, Manuel|||0000-0001-8340-8172
Clará Velasco, Alberto
Dilmé, Jaume|||0000-0003-0127-0064
Soria Fernández, José Manuel|||0000-0002-6226-4293
Camacho, Mercedes|||0000-0001-5970-3294
Martinez-Perez, Angel|||0000-0002-5934-1454
Sabater-Lleal, Maria|||0000-0002-0128-379X
author_role author
author2 Calsina Juscafresa, Laura
Vega-Méndez, Antón
Lobato-Delgado, Bárbara|||0000-0001-6218-5774
Fité, Joan|||0000-0001-7820-6509
Soto, Begoña|||0000-0002-5965-1292
Nieto Fernández, Lluís
de la Rosa Estadella, Mireia|||0000-0002-1384-4590
Uribezubia, Ager
Romero, Jose-María
Plana, Emma|||0000-0002-8457-6984
Miralles Hernández, Manuel|||0000-0001-8340-8172
Clará Velasco, Alberto
Dilmé, Jaume|||0000-0003-0127-0064
Soria Fernández, José Manuel|||0000-0002-6226-4293
Camacho, Mercedes|||0000-0001-5970-3294
Martinez-Perez, Angel|||0000-0002-5934-1454
Sabater-Lleal, Maria|||0000-0002-0128-379X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Abdominal Aortic Aneurysm (AAA)
Risk prediction models
AAA screening
Risk factors
topic Abdominal Aortic Aneurysm (AAA)
Risk prediction models
AAA screening
Risk factors
description Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/319831
https://dx.doi.org/urn:doi:10.3390/jcm14134720
url https://ddd.uab.cat/record/319831
https://dx.doi.org/urn:doi:10.3390/jcm14134720
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-109844RB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2023-149864OB-I00
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CPII22/00007
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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