Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing

[EN] This work reports the development and application of two liquid-core microstructured polymer optical fibers (LCmPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform,with the aim of detecting glucose in aqueous solutions in the clinicall...

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Autores: Azkune Ulla, Mikel, Frosch, Timea, Arrospide Zabala, Eneko, Aldabaldetreku Etxeberria, Gotzon, Bikandi Irazabal, Iñaki, Zubia Zaballa, Joseba Andoni, Popp, Jurgen, Frosch, Torsten
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/64683
Acceso en línea:http://hdl.handle.net/10810/64683
Access Level:acceso abierto
Palabra clave:fiber enhanced Raman spectroscopy
glucose sensing
hollow-core microstructured polymer optical fibers
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spelling Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose SensingAzkune Ulla, MikelFrosch, TimeaArrospide Zabala, EnekoAldabaldetreku Etxeberria, GotzonBikandi Irazabal, IñakiZubia Zaballa, Joseba AndoniPopp, JurgenFrosch, Torstenfiber enhanced Raman spectroscopyglucose sensinghollow-core microstructured polymer optical fibers[EN] This work reports the development and application of two liquid-core microstructured polymer optical fibers (LCmPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform,with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium–glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of theRaman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine.This work was supported in part by European Regional Development Fund, in part by the Ministerio de Economía y Competitividad under Project TEC2015-638263-C03-1-R, in part by Gobierno Vasco/Eusko Jaurlaritza under Projects IT933-16 and ELKARTEK (KK-2016/0030, KK-2017/00033, KK- 2017/00089, and KK-2016/0059), and in part by the Free State of Thuringia, Germany (2015 FE 9012). The work of M. Azkune was supported in part by a research fellowship from the University of the Basque Country, Vicerrectorado de Euskera y Formación Continua. (Corresponding author: Mikel Azkune.)IEEE202420242019info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/64683reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/TEC2015-638263-C03-1-R/https://ieeexplore.ieee.org/document/8678391info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0oai:addi.ehu.eus:10810/646832026-06-18T09:23:17Z
dc.title.none.fl_str_mv Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
title Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
spellingShingle Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
Azkune Ulla, Mikel
fiber enhanced Raman spectroscopy
glucose sensing
hollow-core microstructured polymer optical fibers
title_short Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
title_full Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
title_fullStr Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
title_full_unstemmed Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
title_sort Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing
dc.creator.none.fl_str_mv Azkune Ulla, Mikel
Frosch, Timea
Arrospide Zabala, Eneko
Aldabaldetreku Etxeberria, Gotzon
Bikandi Irazabal, Iñaki
Zubia Zaballa, Joseba Andoni
Popp, Jurgen
Frosch, Torsten
author Azkune Ulla, Mikel
author_facet Azkune Ulla, Mikel
Frosch, Timea
Arrospide Zabala, Eneko
Aldabaldetreku Etxeberria, Gotzon
Bikandi Irazabal, Iñaki
Zubia Zaballa, Joseba Andoni
Popp, Jurgen
Frosch, Torsten
author_role author
author2 Frosch, Timea
Arrospide Zabala, Eneko
Aldabaldetreku Etxeberria, Gotzon
Bikandi Irazabal, Iñaki
Zubia Zaballa, Joseba Andoni
Popp, Jurgen
Frosch, Torsten
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv fiber enhanced Raman spectroscopy
glucose sensing
hollow-core microstructured polymer optical fibers
topic fiber enhanced Raman spectroscopy
glucose sensing
hollow-core microstructured polymer optical fibers
description [EN] This work reports the development and application of two liquid-core microstructured polymer optical fibers (LCmPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform,with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium–glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of theRaman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/64683
url http://hdl.handle.net/10810/64683
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/TEC2015-638263-C03-1-R/
https://ieeexplore.ieee.org/document/8678391
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IEEE
publisher.none.fl_str_mv IEEE
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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