Functional connectivity of the hippocampus and its subfields in resting-state networks

First published: 30 March 2021

Detalles Bibliográficos
Autores: Ezama, Laura, Hernández-Cabrera, Juan Andrés, Seoane, Sara, Pereda, Ernesto, Janssen, Niels
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/52473
Acceso en línea:http://hdl.handle.net/10810/52473
Access Level:acceso abierto
Palabra clave:CA1
Hippocampal subfields
ICA
Resting-State fMRI
subiculum
id ES_0e5c9864a7be0192c1292f2bbc433d21
oai_identifier_str oai:addi.ehu.eus:10810/52473
network_acronym_str ES
network_name_str España
repository_id_str
spelling Functional connectivity of the hippocampus and its subfields in resting-state networksEzama, LauraHernández-Cabrera, Juan AndrésSeoane, SaraPereda, ErnestoJanssen, NielsCA1Hippocampal subfieldsICAResting-State fMRIsubiculumFirst published: 30 March 2021Many neuroimaging studies have shown that the hippocampus participates in a resting-state network called the default mode network. However, how the hippocampus connects to the default mode network, whether the hippocampus connects to other resting-state networks and how the different hippocampal subfields take part in resting-state networks remains poorly understood. Here, we examined these issues using the high spatial-resolution 7T resting-state fMRI dataset from the Human Connectome Project. We used data-driven techniques that relied on spatially-restricted Independent Component Analysis, Dual Regression and linear mixed-effect group-analyses based on participant-specific brain morphology. The results revealed two main activity hotspots inside the hippocampus. The first hotspot was located in an anterior location and was correlated with the somatomotor network. This network was subserved by co-activity in the CA1, CA3, CA4 and Dentate Gyrus fields. In addition, there was an activity hotspot that extended from middle to posterior locations along the hippocampal long-axis and correlated with the default mode network. This network reflected activity in the Subiculum, CA4 and Dentate Gyrus fields. These results show how different sections of the hippocampus participate in two known resting-state networks and how these two resting-state networks depend on different configurations of hippocampal subfield co-activity.Agencia Canaria de Investigación, Innovación y Sociedad de la Información; Ministerio de Ciencia, Innovación y Universidades, Grant/Award Number: PSI2017-84933- P, PSI2017-91955- EXP and TEC2016-80063- C3- 2- R; NIH Blueprint for Neuroscience Research, Grant/Award Number: 1U54MH091657; McDonnell Center for Systems Neuroscience; European Social Fund (ESF)European Journal of Neuroscience202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/52473reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/PSI2017‐84933-P/info:eu-repo/grantAgreement/MINECO/PSI2017‐91955- EXP/info:eu-repo/grantAgreement/MINECO/TEC2016-80063-C3-2-R/https://onlinelibrary.wiley.com/journal/14609568info:eu-repo/semantics/openAccessThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial- NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.oai:addi.ehu.eus:10810/524732026-06-18T09:23:17Z
dc.title.none.fl_str_mv Functional connectivity of the hippocampus and its subfields in resting-state networks
title Functional connectivity of the hippocampus and its subfields in resting-state networks
spellingShingle Functional connectivity of the hippocampus and its subfields in resting-state networks
Ezama, Laura
CA1
Hippocampal subfields
ICA
Resting-State fMRI
subiculum
title_short Functional connectivity of the hippocampus and its subfields in resting-state networks
title_full Functional connectivity of the hippocampus and its subfields in resting-state networks
title_fullStr Functional connectivity of the hippocampus and its subfields in resting-state networks
title_full_unstemmed Functional connectivity of the hippocampus and its subfields in resting-state networks
title_sort Functional connectivity of the hippocampus and its subfields in resting-state networks
dc.creator.none.fl_str_mv Ezama, Laura
Hernández-Cabrera, Juan Andrés
Seoane, Sara
Pereda, Ernesto
Janssen, Niels
author Ezama, Laura
author_facet Ezama, Laura
Hernández-Cabrera, Juan Andrés
Seoane, Sara
Pereda, Ernesto
Janssen, Niels
author_role author
author2 Hernández-Cabrera, Juan Andrés
Seoane, Sara
Pereda, Ernesto
Janssen, Niels
author2_role author
author
author
author
dc.subject.none.fl_str_mv CA1
Hippocampal subfields
ICA
Resting-State fMRI
subiculum
topic CA1
Hippocampal subfields
ICA
Resting-State fMRI
subiculum
description First published: 30 March 2021
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/52473
url http://hdl.handle.net/10810/52473
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/PSI2017‐84933-P/
info:eu-repo/grantAgreement/MINECO/PSI2017‐91955- EXP/
info:eu-repo/grantAgreement/MINECO/TEC2016-80063-C3-2-R/
https://onlinelibrary.wiley.com/journal/14609568
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Journal of Neuroscience
publisher.none.fl_str_mv European Journal of Neuroscience
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403392462290944
score 15,300719

Similares en LA Referencia