Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study

Background/Objective: Neuroimaging studies have shown brain abnormalities in Down syndrome (DS) but have not clarified the underlying mechanisms of dysfunction. Here, we investigated the degree centrality (DC) abnormalities found in the DS group compared with the control group, and we conducted seed...

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Detalles Bibliográficos
Autores: Cañete-Massé, Cristina, Carbó-Carreté, Maria, Peró, Maribel, Cui, Shi Xian, Yan, Chao Gan, Guàrdia-Olmos, Joan, 1958-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/190780
Acceso en línea:https://hdl.handle.net/2445/190780
Access Level:acceso abierto
Palabra clave:Síndrome de Down
Mapatge del cervell
Imatges per ressonància magnètica
Down syndrome
Brain mapping
Magnetic resonance imaging
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spelling Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI studyCañete-Massé, CristinaCarbó-Carreté, MariaPeró, MaribelCui, Shi XianYan, Chao GanGuàrdia-Olmos, Joan, 1958-Síndrome de DownMapatge del cervellImatges per ressonància magnèticaDown syndromeBrain mappingMagnetic resonance imagingBackground/Objective: Neuroimaging studies have shown brain abnormalities in Down syndrome (DS) but have not clarified the underlying mechanisms of dysfunction. Here, we investigated the degree centrality (DC) abnormalities found in the DS group compared with the control group, and we conducted seed-based functional connectivity (FC) with the significant clusters found in DC. Moreover, we used the significant clusters of DC and the seed-based FC to elucidate differences between brain networks in DS compared with controls. Method: The sample comprised 18 persons with DS (M = 28.67, SD = 4.18) and 18 controls (M = 28.56, SD = 4.26). Both samples underwent resting-state functional magnetic resonance imaging. Results: DC analysis showed increased DC in the DS in temporal and right frontal lobe, as well as in the left caudate and rectus and decreased DC in the DS in regions of the left frontal lobe. Regarding seed-based FC, DS showed increased and decreased FC. Significant differences were also found between networks using Yeo parcellations, showing both hyperconnectivity and hypoconnectivity between and within networks. Conclusions: DC, seed-based FC and brain networks seem altered in DS, finding hypo- and hyperconnectivity depending on the areas. Network analysis revealed between- and within-network differences, and these abnormalities shown in DS could be related to the characteristics of the population.Elsevier España2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/190780Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.ijchp.2022.100341International Journal of Clinical And Health Psychology, 2022, vol. 23, num. 1, p. 100341https://doi.org/10.1016/j.ijchp.2022.100341cc-by-nc-nd (c) sociación Española de Psicología Conductual (AEPC), 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1907802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
title Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
spellingShingle Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
Cañete-Massé, Cristina
Síndrome de Down
Mapatge del cervell
Imatges per ressonància magnètica
Down syndrome
Brain mapping
Magnetic resonance imaging
title_short Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
title_full Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
title_fullStr Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
title_full_unstemmed Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
title_sort Abnormal degree centrality and functional connectivity in Down syndrome: A resting-state fMRI study
dc.creator.none.fl_str_mv Cañete-Massé, Cristina
Carbó-Carreté, Maria
Peró, Maribel
Cui, Shi Xian
Yan, Chao Gan
Guàrdia-Olmos, Joan, 1958-
author Cañete-Massé, Cristina
author_facet Cañete-Massé, Cristina
Carbó-Carreté, Maria
Peró, Maribel
Cui, Shi Xian
Yan, Chao Gan
Guàrdia-Olmos, Joan, 1958-
author_role author
author2 Carbó-Carreté, Maria
Peró, Maribel
Cui, Shi Xian
Yan, Chao Gan
Guàrdia-Olmos, Joan, 1958-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome de Down
Mapatge del cervell
Imatges per ressonància magnètica
Down syndrome
Brain mapping
Magnetic resonance imaging
topic Síndrome de Down
Mapatge del cervell
Imatges per ressonància magnètica
Down syndrome
Brain mapping
Magnetic resonance imaging
description Background/Objective: Neuroimaging studies have shown brain abnormalities in Down syndrome (DS) but have not clarified the underlying mechanisms of dysfunction. Here, we investigated the degree centrality (DC) abnormalities found in the DS group compared with the control group, and we conducted seed-based functional connectivity (FC) with the significant clusters found in DC. Moreover, we used the significant clusters of DC and the seed-based FC to elucidate differences between brain networks in DS compared with controls. Method: The sample comprised 18 persons with DS (M = 28.67, SD = 4.18) and 18 controls (M = 28.56, SD = 4.26). Both samples underwent resting-state functional magnetic resonance imaging. Results: DC analysis showed increased DC in the DS in temporal and right frontal lobe, as well as in the left caudate and rectus and decreased DC in the DS in regions of the left frontal lobe. Regarding seed-based FC, DS showed increased and decreased FC. Significant differences were also found between networks using Yeo parcellations, showing both hyperconnectivity and hypoconnectivity between and within networks. Conclusions: DC, seed-based FC and brain networks seem altered in DS, finding hypo- and hyperconnectivity depending on the areas. Network analysis revealed between- and within-network differences, and these abnormalities shown in DS could be related to the characteristics of the population.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/190780
url https://hdl.handle.net/2445/190780
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ijchp.2022.100341
International Journal of Clinical And Health Psychology, 2022, vol. 23, num. 1, p. 100341
https://doi.org/10.1016/j.ijchp.2022.100341
dc.rights.none.fl_str_mv cc-by-nc-nd (c) sociación Española de Psicología Conductual (AEPC), 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) sociación Española de Psicología Conductual (AEPC), 2022
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier España
publisher.none.fl_str_mv Elsevier España
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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