Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons

Company Devesa, Verónica; Andreu Cervera, Abraham; Madrigal Verdú, María del Pilar; Andrés Bayón, Belén; Almagro García, Francisca de Paula; Chedotal, Alain; López Bendito, Guillermina; Martínez Pérez, Salvador; Echevarría, Diego; Moreno Bravo, Juan Antonio; de Puelles Martínez de La Torre, Eduardo

Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons

The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organi...

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Autores:	Company Devesa, Verónica, Andreu Cervera, Abraham, Madrigal Verdú, María del Pilar, Andrés Bayón, Belén, Almagro García, Francisca de Paula, Chedotal, Alain, López Bendito, Guillermina, Martínez Pérez, Salvador, Echevarría, Diego, Moreno Bravo, Juan Antonio, de Puelles Martínez de La Torre, Eduardo
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universidad Miguel Hernández de Elche
Repositorio:	REDIUMH. Depósito Digital de la UMH
OAI Identifier:	oai:dspace.umh.es:11000/31168
Acceso en línea:	https://hdl.handle.net/11000/31168
Access Level:	acceso abierto
Palabra clave:	DCC axon guidance fasciculus retroflexus habenula netrin 1 substantia nigra pars compacta ventral tegmental area

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spelling	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular AxonsCompany Devesa, VerónicaAndreu Cervera, AbrahamMadrigal Verdú, María del PilarAndrés Bayón, BelénAlmagro García, Francisca de PaulaChedotal, AlainLópez Bendito, GuillerminaMartínez Pérez, SalvadorEchevarría, DiegoMoreno Bravo, Juan Antoniode Puelles Martínez de La Torre, EduardoDCCaxon guidancefasciculus retroflexushabenulanetrin 1substantia nigra pars compactaventral tegmental areaThe fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organization of habenular circuitry requires complex molecular programs to control the wiring of the habenula during development. However, the mechanisms guiding the habenular axons toward their targets remain mostly unknown. Here, we demonstrate the role of the mesodiencephalic dopaminergic neurons (substantia nigra pars compacta and ventral tegmental area) as an intermediate target for the correct medial habenular axons navigation along the anteroposterior axis. These neuronal populations are distributed along the anteroposterior trajectory of these axons in the mesodiencephalic basal plate. Using in vitro and in vivo experiments, we determined that this navigation is the result of netrin 1 attraction generated by the mesodiencephalic dopaminergic neurons. This attraction is mediated by the receptor deleted in colorectal cancer (DCC), which is strongly expressed in the medial habenular axons. The increment in our knowledge on the fasciculus retroflexus trajectory guidance mechanisms opens the possibility of analyzing if its alteration in mental health patients could account for some of their symptomsFrontiers Media [Commercial Publisher]Departamentos de la UMH::Patología y CirugíaDepartamentos de la UMH::Histología y AnatomíaInstituto de Neurociencias202420242021info:eu-repo/semantics/articleapplication/pdf16application/pdfhttps://hdl.handle.net/11000/31168reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheIngléshttps://doi.org/10.3389/fcell.2021.682067info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/311682026-05-27T13:36:21Z
dc.title.none.fl_str_mv	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
title	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
spellingShingle	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons Company Devesa, Verónica DCC axon guidance fasciculus retroflexus habenula netrin 1 substantia nigra pars compacta ventral tegmental area
title_short	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
title_full	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
title_fullStr	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
title_full_unstemmed	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
title_sort	Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
dc.creator.none.fl_str_mv	Company Devesa, Verónica Andreu Cervera, Abraham Madrigal Verdú, María del Pilar Andrés Bayón, Belén Almagro García, Francisca de Paula Chedotal, Alain López Bendito, Guillermina Martínez Pérez, Salvador Echevarría, Diego Moreno Bravo, Juan Antonio de Puelles Martínez de La Torre, Eduardo
author	Company Devesa, Verónica
author_facet	Company Devesa, Verónica Andreu Cervera, Abraham Madrigal Verdú, María del Pilar Andrés Bayón, Belén Almagro García, Francisca de Paula Chedotal, Alain López Bendito, Guillermina Martínez Pérez, Salvador Echevarría, Diego Moreno Bravo, Juan Antonio de Puelles Martínez de La Torre, Eduardo
author_role	author
author2	Andreu Cervera, Abraham Madrigal Verdú, María del Pilar Andrés Bayón, Belén Almagro García, Francisca de Paula Chedotal, Alain López Bendito, Guillermina Martínez Pérez, Salvador Echevarría, Diego Moreno Bravo, Juan Antonio de Puelles Martínez de La Torre, Eduardo
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	Departamentos de la UMH::Patología y Cirugía Departamentos de la UMH::Histología y Anatomía Instituto de Neurociencias
dc.subject.none.fl_str_mv	DCC axon guidance fasciculus retroflexus habenula netrin 1 substantia nigra pars compacta ventral tegmental area
topic	DCC axon guidance fasciculus retroflexus habenula netrin 1 substantia nigra pars compacta ventral tegmental area
description	The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the rostral hindbrain. The proper functional organization of habenular circuitry requires complex molecular programs to control the wiring of the habenula during development. However, the mechanisms guiding the habenular axons toward their targets remain mostly unknown. Here, we demonstrate the role of the mesodiencephalic dopaminergic neurons (substantia nigra pars compacta and ventral tegmental area) as an intermediate target for the correct medial habenular axons navigation along the anteroposterior axis. These neuronal populations are distributed along the anteroposterior trajectory of these axons in the mesodiencephalic basal plate. Using in vitro and in vivo experiments, we determined that this navigation is the result of netrin 1 attraction generated by the mesodiencephalic dopaminergic neurons. This attraction is mediated by the receptor deleted in colorectal cancer (DCC), which is strongly expressed in the medial habenular axons. The increment in our knowledge on the fasciculus retroflexus trajectory guidance mechanisms opens the possibility of analyzing if its alteration in mental health patients could account for some of their symptoms
publishDate	2021
dc.date.none.fl_str_mv	2021 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/11000/31168
url	https://hdl.handle.net/11000/31168
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	https://doi.org/10.3389/fcell.2021.682067
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv	application/pdf 16 application/pdf
dc.publisher.none.fl_str_mv	Frontiers Media [Commercial Publisher]
publisher.none.fl_str_mv	Frontiers Media [Commercial Publisher]
dc.source.none.fl_str_mv	reponame:REDIUMH. Depósito Digital de la UMH instname:Universidad Miguel Hernández de Elche
instname_str	Universidad Miguel Hernández de Elche
reponame_str	REDIUMH. Depósito Digital de la UMH
collection	REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.300724

Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons

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