Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling

6 páginas, 2 figuras, 1 tabla.-- El pdf del artículo es la versión post-print.

Detalhes bibliográficos
Autores: Balgoma, David, Montero, Olimpio, Balboa, María A., Balsinde, Jesús
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2010
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/49345
Acesso em linha:http://hdl.handle.net/10261/49345
Access Level:acceso abierto
Palavra-chave:Lipidomics
Phospholipase A2
Mass spectrometry
Arachidonic acid
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spelling Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodelingBalgoma, DavidMontero, OlimpioBalboa, María A.Balsinde, JesúsLipidomicsPhospholipase A2Mass spectrometryArachidonic acid6 páginas, 2 figuras, 1 tabla.-- El pdf del artículo es la versión post-print.The distribution of fatty acids among cellular glycerophospholipids is finely regulated by the CoA-dependent acylation of lysophospholipids followed by transacylation reactions. Arachidonic acid is the fatty acid precursor of a wide family of bioactive compounds called the eicosanoids, with key roles in innate immunity and inflammation. Because availability of free AA constitutes a rate-limiting step in the generation of eicosanoids by mammalian cells, many studies have been devoted to characterize the processes of arachidonate liberation from phospholipids by phospholipase A2s and its re-incorporation and further remodeling back into phospholipids by acyltransferases and transacylases. These studies have traditionally been conducted by using radioactive precursors which do not allow the identification of the phospholipid molecular species involved in these processes. Nowadays, lipidomic approaches utilizing mass spectrometry provide a new frame for the analysis of unique phospholipid species involved in fatty acid release and phospholipid incorporation and remodeling. This review focuses on the mass spectrometry techniques applied to the study of phospholipid fatty acid trafficking and the recent advances that have been achieved by the use of this technique.Work in our laboratory was supported by the Spanish Ministry of Science and Innovation (Grants BFU2007-67154 and SAF2007-60055) and the Regional Government of Castile and León (Grant CSI09-A08). CIBERDEM is an initiative of Instituto de Salud Carlos III.Peer reviewedElsevier201220122010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/49345reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.biochi.2009.11.010info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/493452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
title Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
spellingShingle Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
Balgoma, David
Lipidomics
Phospholipase A2
Mass spectrometry
Arachidonic acid
title_short Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
title_full Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
title_fullStr Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
title_full_unstemmed Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
title_sort Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling
dc.creator.none.fl_str_mv Balgoma, David
Montero, Olimpio
Balboa, María A.
Balsinde, Jesús
author Balgoma, David
author_facet Balgoma, David
Montero, Olimpio
Balboa, María A.
Balsinde, Jesús
author_role author
author2 Montero, Olimpio
Balboa, María A.
Balsinde, Jesús
author2_role author
author
author
dc.subject.none.fl_str_mv Lipidomics
Phospholipase A2
Mass spectrometry
Arachidonic acid
topic Lipidomics
Phospholipase A2
Mass spectrometry
Arachidonic acid
description 6 páginas, 2 figuras, 1 tabla.-- El pdf del artículo es la versión post-print.
publishDate 2010
dc.date.none.fl_str_mv 2010
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/49345
url http://hdl.handle.net/10261/49345
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.biochi.2009.11.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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