Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study

Background: The nature of allergens and route and dose of exposure may affect the natural development of IgE and IgG responses. Objective: We sought to investigate the natural IgE and IgG responses toward a large panel of respiratory and food allergens in subjects exposed to different respiratory al...

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Authors: Siroux, Valérie, Lupinek, Christian, Resch, Yvonne, Curin, Mirela, Just, Jocelyne, Keil, Thomas, Kiss, Renata, Lodrup Carlsen, Karin C., Melén, Erik, Nadif, Rachel, Pin, Isabelle, Skrindo, Ingebjorg, Vrtala, Susanne, Wickman, Magnus, Antó i Boqué, Josep Maria, Valenta, Rudolf, Bousquet, Jean
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/37030
Online Access:http://hdl.handle.net/10230/37030
http://dx.doi.org/10.1016/j.jaci.2016.05.023
Access Level:Open access
Keyword:IgE
IgG
Allergen components
Respiratory allergens
Food allergens
EGEA
Cohort
Epidemiology
MeDALL
Microarray
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spelling Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA studySiroux, ValérieLupinek, ChristianResch, YvonneCurin, MirelaJust, JocelyneKeil, ThomasKiss, RenataLodrup Carlsen, Karin C.Melén, ErikNadif, RachelPin, IsabelleSkrindo, IngebjorgVrtala, SusanneWickman, MagnusAntó i Boqué, Josep MariaValenta, RudolfBousquet, JeanIgEIgGAllergen componentsRespiratory allergensFood allergensEGEACohortEpidemiologyMeDALLMicroarrayBackground: The nature of allergens and route and dose of exposure may affect the natural development of IgE and IgG responses. Objective: We sought to investigate the natural IgE and IgG responses toward a large panel of respiratory and food allergens in subjects exposed to different respiratory allergen loads. Methods: A cross-sectional analysis was conducted in 340 adults of the EGEA (Epidemiological study of the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy) (170 with and 170 without asthma) cohort. IgE and IgG responses to 47 inhalant and food allergen components were analyzed in sera using allergen microarray and compared between 5 French regions according to the route of allergen exposure (inhaled vs food allergens). Results: Overall 48.8% of the population had allergen-specific IgE levels of 0.3 ISAC standardized units (ISU) or more to at least 1 of the 47 allergens with no significant differences across the regions. For ubiquitous respiratory allergens (ie, grass, olive/ash pollen, house dust mites), specific IgE did not show marked differences between regions and specific IgG (≥0.5 ISU) was present in most subjects everywhere. For regionally occurring pollen allergens (ragweed, birch, cypress), IgE sensitization was significantly associated with regional pollen exposure. For airborne allergens cross-reacting with food allergens, frequent IgG recognition was observed even in regions with low allergen prevalence (Bet v 1) or for allergens less frequently recognized by IgE (profilins). Conclusions: The variability in allergen-specific IgE and IgG frequencies depends on exposure, route of exposure, and overall immunogenicity of the allergen. Allergen contact by the oral route might preferentially induce IgG responses.The study was supported in part by Inserm Aviesan Itmo santé publique, the Scientific committee “AGIR for chronic diseases,” grant F4605 of the Austrian Science Fund (FWF [Fonds zur Förderung der wissenschaftlichen Forschung]) to R.V. and by the European Commission's Seventh Framework 29 Program MeDALL under grant agreement no. 261357.Elsevier201920192017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/37030http://dx.doi.org/10.1016/j.jaci.2016.05.023reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJournal of Allergy and Clinical Immunology. 2017;139(2):643-54info:eu-repo/grantAgreement/EC/FP7/261357© Elsevier http://dx.doi.org/10.1016/j.jaci.2016.05.023info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/370302026-06-12T07:21:37Z
dc.title.none.fl_str_mv Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
title Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
spellingShingle Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
Siroux, Valérie
IgE
IgG
Allergen components
Respiratory allergens
Food allergens
EGEA
Cohort
Epidemiology
MeDALL
Microarray
title_short Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
title_full Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
title_fullStr Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
title_full_unstemmed Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
title_sort Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
dc.creator.none.fl_str_mv Siroux, Valérie
Lupinek, Christian
Resch, Yvonne
Curin, Mirela
Just, Jocelyne
Keil, Thomas
Kiss, Renata
Lodrup Carlsen, Karin C.
Melén, Erik
Nadif, Rachel
Pin, Isabelle
Skrindo, Ingebjorg
Vrtala, Susanne
Wickman, Magnus
Antó i Boqué, Josep Maria
Valenta, Rudolf
Bousquet, Jean
author Siroux, Valérie
author_facet Siroux, Valérie
Lupinek, Christian
Resch, Yvonne
Curin, Mirela
Just, Jocelyne
Keil, Thomas
Kiss, Renata
Lodrup Carlsen, Karin C.
Melén, Erik
Nadif, Rachel
Pin, Isabelle
Skrindo, Ingebjorg
Vrtala, Susanne
Wickman, Magnus
Antó i Boqué, Josep Maria
Valenta, Rudolf
Bousquet, Jean
author_role author
author2 Lupinek, Christian
Resch, Yvonne
Curin, Mirela
Just, Jocelyne
Keil, Thomas
Kiss, Renata
Lodrup Carlsen, Karin C.
Melén, Erik
Nadif, Rachel
Pin, Isabelle
Skrindo, Ingebjorg
Vrtala, Susanne
Wickman, Magnus
Antó i Boqué, Josep Maria
Valenta, Rudolf
Bousquet, Jean
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv IgE
IgG
Allergen components
Respiratory allergens
Food allergens
EGEA
Cohort
Epidemiology
MeDALL
Microarray
topic IgE
IgG
Allergen components
Respiratory allergens
Food allergens
EGEA
Cohort
Epidemiology
MeDALL
Microarray
description Background: The nature of allergens and route and dose of exposure may affect the natural development of IgE and IgG responses. Objective: We sought to investigate the natural IgE and IgG responses toward a large panel of respiratory and food allergens in subjects exposed to different respiratory allergen loads. Methods: A cross-sectional analysis was conducted in 340 adults of the EGEA (Epidemiological study of the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy) (170 with and 170 without asthma) cohort. IgE and IgG responses to 47 inhalant and food allergen components were analyzed in sera using allergen microarray and compared between 5 French regions according to the route of allergen exposure (inhaled vs food allergens). Results: Overall 48.8% of the population had allergen-specific IgE levels of 0.3 ISAC standardized units (ISU) or more to at least 1 of the 47 allergens with no significant differences across the regions. For ubiquitous respiratory allergens (ie, grass, olive/ash pollen, house dust mites), specific IgE did not show marked differences between regions and specific IgG (≥0.5 ISU) was present in most subjects everywhere. For regionally occurring pollen allergens (ragweed, birch, cypress), IgE sensitization was significantly associated with regional pollen exposure. For airborne allergens cross-reacting with food allergens, frequent IgG recognition was observed even in regions with low allergen prevalence (Bet v 1) or for allergens less frequently recognized by IgE (profilins). Conclusions: The variability in allergen-specific IgE and IgG frequencies depends on exposure, route of exposure, and overall immunogenicity of the allergen. Allergen contact by the oral route might preferentially induce IgG responses.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/37030
http://dx.doi.org/10.1016/j.jaci.2016.05.023
url http://hdl.handle.net/10230/37030
http://dx.doi.org/10.1016/j.jaci.2016.05.023
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Allergy and Clinical Immunology. 2017;139(2):643-54
info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.jaci.2016.05.023
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.jaci.2016.05.023
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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