Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction

[EN] The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (L...

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Authors: Río González, María Luisa del, Jones, N. D., Buhler, Leo, Norris, Paula, Shintani, Yasushi, Ware, Carl F., Rodríguez Barbosa, José Ignacio
Format: article
Status:Versión aceptada para publicación
Publication Date:2012
Country:España
Institution:Ajuntament de Barcelona
Repository:BULERIA. Repositorio Institucional de la Universidad de León
OAI Identifier:oai:buleria.unileon.es:10612/24256
Online Access:https://journals.aai.org/jimmunol/article/188/10/4885/85565/Selective-Blockade-of-Herpesvirus-Entry-Mediator-B
https://hdl.handle.net/10612/24256
Access Level:Open access
Keyword:Inmunología
Veterinaria
HVEM
TNFRSF14
3109 Ciencias Veterinarias
3109.03 Inmunología
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oai_identifier_str oai:buleria.unileon.es:10612/24256
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spelling Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host ReactionRío González, María Luisa delJones, N. D.Buhler, LeoNorris, PaulaShintani, YasushiWare, Carl F.Rodríguez Barbosa, José IgnacioInmunologíaVeterinariaHVEMTNFRSF143109 Ciencias Veterinarias3109.03 Inmunología[EN] The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect the differential contributions of HVEM/BTLA and HVEM/LIGHT interactions, topographically-specific, competitive, and nonblocking anti-HVEM Abs that inhibit BTLA binding, but not LIGHT, were developed. We demonstrate that a BTLA-specific competitor attenuated the course of acute graft-versus-host reaction in a murine F 1 transfer semiallogeneic model. Selective HVEM/BTLA blockade did not inhibit donor T cell infiltration into graft-versus-host reaction target organs, but decreased the functional activity of the alloreactive T cells. These results highlight the critical role of HVEM/BTLA pathway in the control of the allogeneic immune response and identify a new therapeutic target for transplantation and autoimmune diseasesSIThis work has been supported by Grants FIS PI#10/01039 (Fondo de Investigaciones Sanitarias, Ministry of Health, Spanish Government) and LE007A10-2 (Department of Education of the Regional Government, Junta de Castilla y Leon) to J.-I.R.-B.American Association of ImmunologistsInmunologiaFacultad de Veterinaria2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://journals.aai.org/jimmunol/article/188/10/4885/85565/Selective-Blockade-of-Herpesvirus-Entry-Mediator-Bhttps://hdl.handle.net/10612/24256reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Ajuntament de BarcelonaInglésinfo:eu-repo/grantAgreement/Junta de Castilla y León//LE007A10-2http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/242562026-06-24T12:43:27Z
dc.title.none.fl_str_mv Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
title Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
spellingShingle Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
Río González, María Luisa del
Inmunología
Veterinaria
HVEM
TNFRSF14
3109 Ciencias Veterinarias
3109.03 Inmunología
title_short Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
title_full Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
title_fullStr Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
title_full_unstemmed Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
title_sort Selective Blockade of Herpesvirus Entry Mediator–B and T Lymphocyte Attenuator Pathway Ameliorates Acute Graft-versus-Host Reaction
dc.creator.none.fl_str_mv Río González, María Luisa del
Jones, N. D.
Buhler, Leo
Norris, Paula
Shintani, Yasushi
Ware, Carl F.
Rodríguez Barbosa, José Ignacio
author Río González, María Luisa del
author_facet Río González, María Luisa del
Jones, N. D.
Buhler, Leo
Norris, Paula
Shintani, Yasushi
Ware, Carl F.
Rodríguez Barbosa, José Ignacio
author_role author
author2 Jones, N. D.
Buhler, Leo
Norris, Paula
Shintani, Yasushi
Ware, Carl F.
Rodríguez Barbosa, José Ignacio
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Inmunologia
Facultad de Veterinaria
dc.subject.none.fl_str_mv Inmunología
Veterinaria
HVEM
TNFRSF14
3109 Ciencias Veterinarias
3109.03 Inmunología
topic Inmunología
Veterinaria
HVEM
TNFRSF14
3109 Ciencias Veterinarias
3109.03 Inmunología
description [EN] The cosignaling network mediated by the herpesvirus entry mediator (HVEM; TNFRSF14) functions as a dual directional system that involves proinflammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes (LIGHT; TNFSF14), and the inhibitory Ig family member B and T lymphocyte attenuator (BTLA). To dissect the differential contributions of HVEM/BTLA and HVEM/LIGHT interactions, topographically-specific, competitive, and nonblocking anti-HVEM Abs that inhibit BTLA binding, but not LIGHT, were developed. We demonstrate that a BTLA-specific competitor attenuated the course of acute graft-versus-host reaction in a murine F 1 transfer semiallogeneic model. Selective HVEM/BTLA blockade did not inhibit donor T cell infiltration into graft-versus-host reaction target organs, but decreased the functional activity of the alloreactive T cells. These results highlight the critical role of HVEM/BTLA pathway in the control of the allogeneic immune response and identify a new therapeutic target for transplantation and autoimmune diseases
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://journals.aai.org/jimmunol/article/188/10/4885/85565/Selective-Blockade-of-Herpesvirus-Entry-Mediator-B
https://hdl.handle.net/10612/24256
url https://journals.aai.org/jimmunol/article/188/10/4885/85565/Selective-Blockade-of-Herpesvirus-Entry-Mediator-B
https://hdl.handle.net/10612/24256
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/Junta de Castilla y León//LE007A10-2
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:BULERIA. Repositorio Institucional de la Universidad de León
instname:Ajuntament de Barcelona
instname_str Ajuntament de Barcelona
reponame_str BULERIA. Repositorio Institucional de la Universidad de León
collection BULERIA. Repositorio Institucional de la Universidad de León
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403367903592448
score 15,81155

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