TGFβ controls ovarian cancer cell proliferation

There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research...

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Autores: Alsina Sanchís, Elisenda, Figueras i Amat, Agnès, Lahiguera, Álvaro, Gil-Martín, Marta, Pardo, Beatriz, Piulats, Josep M., Martí, Lola, Ponce i Sebastià, Jordi, Matias-Guiu, Xavier, 1958-, Vidal-Bel, August, Villanueva Garatachea, Alberto, Viñals Canals, Francesc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/120091
Acceso en línea:https://hdl.handle.net/2445/120091
Access Level:acceso abierto
Palabra clave:Factors de creixement
Càncer d'ovari
Proliferació cel·lular
Growth factors
Ovarian cancer
Cell proliferation
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spelling TGFβ controls ovarian cancer cell proliferationAlsina Sanchís, ElisendaFigueras i Amat, AgnèsLahiguera, ÁlvaroGil-Martín, MartaPardo, BeatrizPiulats, Josep M.Martí, LolaPonce i Sebastià, JordiMatias-Guiu, Xavier, 1958-Vidal-Bel, AugustVillanueva Garatachea, AlbertoViñals Canals, FrancescFactors de creixementCàncer d'ovariProliferació cel·lularGrowth factorsOvarian cancerCell proliferationThere have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer. This article considers the involvement of TGFβ in ovarian cancer progression, and reviews the various mechanisms that enable the TGFβ signaling pathway to control ovarian cancer cell proliferation. These mechanistic explanations support the therapeutic use of TGFβ inhibitors in ovarian cancer, which are currently in the early phases of development.MDPI2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/120091Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms18081658International Journal of Molecular Sciences, 2017, vol. 18, num. 8, p. 1658https://doi.org/10.3390/ijms18081658cc-by (c) Alsina Sanchís, Elisenda et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1200912026-05-29T05:05:01Z
dc.title.none.fl_str_mv TGFβ controls ovarian cancer cell proliferation
title TGFβ controls ovarian cancer cell proliferation
spellingShingle TGFβ controls ovarian cancer cell proliferation
Alsina Sanchís, Elisenda
Factors de creixement
Càncer d'ovari
Proliferació cel·lular
Growth factors
Ovarian cancer
Cell proliferation
title_short TGFβ controls ovarian cancer cell proliferation
title_full TGFβ controls ovarian cancer cell proliferation
title_fullStr TGFβ controls ovarian cancer cell proliferation
title_full_unstemmed TGFβ controls ovarian cancer cell proliferation
title_sort TGFβ controls ovarian cancer cell proliferation
dc.creator.none.fl_str_mv Alsina Sanchís, Elisenda
Figueras i Amat, Agnès
Lahiguera, Álvaro
Gil-Martín, Marta
Pardo, Beatriz
Piulats, Josep M.
Martí, Lola
Ponce i Sebastià, Jordi
Matias-Guiu, Xavier, 1958-
Vidal-Bel, August
Villanueva Garatachea, Alberto
Viñals Canals, Francesc
author Alsina Sanchís, Elisenda
author_facet Alsina Sanchís, Elisenda
Figueras i Amat, Agnès
Lahiguera, Álvaro
Gil-Martín, Marta
Pardo, Beatriz
Piulats, Josep M.
Martí, Lola
Ponce i Sebastià, Jordi
Matias-Guiu, Xavier, 1958-
Vidal-Bel, August
Villanueva Garatachea, Alberto
Viñals Canals, Francesc
author_role author
author2 Figueras i Amat, Agnès
Lahiguera, Álvaro
Gil-Martín, Marta
Pardo, Beatriz
Piulats, Josep M.
Martí, Lola
Ponce i Sebastià, Jordi
Matias-Guiu, Xavier, 1958-
Vidal-Bel, August
Villanueva Garatachea, Alberto
Viñals Canals, Francesc
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Factors de creixement
Càncer d'ovari
Proliferació cel·lular
Growth factors
Ovarian cancer
Cell proliferation
topic Factors de creixement
Càncer d'ovari
Proliferació cel·lular
Growth factors
Ovarian cancer
Cell proliferation
description There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer. This article considers the involvement of TGFβ in ovarian cancer progression, and reviews the various mechanisms that enable the TGFβ signaling pathway to control ovarian cancer cell proliferation. These mechanistic explanations support the therapeutic use of TGFβ inhibitors in ovarian cancer, which are currently in the early phases of development.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/120091
url https://hdl.handle.net/2445/120091
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms18081658
International Journal of Molecular Sciences, 2017, vol. 18, num. 8, p. 1658
https://doi.org/10.3390/ijms18081658
dc.rights.none.fl_str_mv cc-by (c) Alsina Sanchís, Elisenda et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Alsina Sanchís, Elisenda et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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