Response of Lactobacillus casei BL23 to phenolic compounds

2 tables, 2 figures.-- Article first published online: 17 OCT 2011.-- The definitive version is available at www3.interscience.wiley.com

Detalles Bibliográficos
Autores: Rivas Sendra, A, Landete, José María, Alcántara, Cristina, Zúñiga, Manuel
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/41910
Acceso en línea:http://hdl.handle.net/10261/41910
Access Level:acceso abierto
Palabra clave:ClpP
HtrA
Inhibition of growth
Lactobacillus casei
Phenolic compound
Purine metabolism
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spelling Response of Lactobacillus casei BL23 to phenolic compoundsRivas Sendra, ALandete, José MaríaAlcántara, CristinaZúñiga, ManuelClpPHtrAInhibition of growthLactobacillus caseiPhenolic compoundPurine metabolism2 tables, 2 figures.-- Article first published online: 17 OCT 2011.-- The definitive version is available at www3.interscience.wiley.comAims:  To determine the inhibitory effect of phenolic compounds on Lactobacillus casei BL23, the role of two component signal transduction systems (TCS) and the response of Lact. casei BL23 to p-coumaric acid. Methods and Results:  Growth of Lact. casei BL23 and 17 derivative strains defective in each TCS harboured by this strain in the presence of p-coumaric acid, ferulic acid, caffeic acid or methyl gallate was monitored. Furthermore, changes in the protein content of Lact. casei BL23 when exposed to p-coumaric acid were evaluated by 2D-SDS-PAGE. Eleven proteins differentially expressed in the presence of p-coumaric acid were detected. Six of them could be identified: ClpP and HtrA, involved in protein turnover and folding, acetyl-CoA carboxylase, involved in lipid metabolism, and an arginyl-tRNA synthetase were more abundant, whereas PurL and PurN, involved in purine biosynthesis, were less abundant. Conclusions:  No significant differences were observed between the parental strain and the TCS-defective mutants. p-Coumaric acid elicited a response against membrane and cytoplasmic damages. Significance and Impact of the Study:  The inhibitory effect of phenolic compounds on Lact. casei BL23 has been determined. For the first time, cytoplasmic proteins presumably involved in the response of Lact. casei BL23 against p-coumaric acid have been identified.This work was financed by AGL2010-15679 and Consolider Fun-C-Food CSD2007-00063 funds from the Spanish Ministry of Science and Innovation (MICINN) and FEDER. J.M. Landete enjoyed a postdoctoral contract of the programme ‘Juan de la Cierva’ (MICINN).Peer reviewedJohn Wiley & SonsSociety for Applied Microbiology201120112011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/41910reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1111/j.1365-2672.2011.05160.xinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/419102026-05-22T06:33:51Z
dc.title.none.fl_str_mv Response of Lactobacillus casei BL23 to phenolic compounds
title Response of Lactobacillus casei BL23 to phenolic compounds
spellingShingle Response of Lactobacillus casei BL23 to phenolic compounds
Rivas Sendra, A
ClpP
HtrA
Inhibition of growth
Lactobacillus casei
Phenolic compound
Purine metabolism
title_short Response of Lactobacillus casei BL23 to phenolic compounds
title_full Response of Lactobacillus casei BL23 to phenolic compounds
title_fullStr Response of Lactobacillus casei BL23 to phenolic compounds
title_full_unstemmed Response of Lactobacillus casei BL23 to phenolic compounds
title_sort Response of Lactobacillus casei BL23 to phenolic compounds
dc.creator.none.fl_str_mv Rivas Sendra, A
Landete, José María
Alcántara, Cristina
Zúñiga, Manuel
author Rivas Sendra, A
author_facet Rivas Sendra, A
Landete, José María
Alcántara, Cristina
Zúñiga, Manuel
author_role author
author2 Landete, José María
Alcántara, Cristina
Zúñiga, Manuel
author2_role author
author
author
dc.subject.none.fl_str_mv ClpP
HtrA
Inhibition of growth
Lactobacillus casei
Phenolic compound
Purine metabolism
topic ClpP
HtrA
Inhibition of growth
Lactobacillus casei
Phenolic compound
Purine metabolism
description 2 tables, 2 figures.-- Article first published online: 17 OCT 2011.-- The definitive version is available at www3.interscience.wiley.com
publishDate 2011
dc.date.none.fl_str_mv 2011
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/41910
url http://hdl.handle.net/10261/41910
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1111/j.1365-2672.2011.05160.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
Society for Applied Microbiology
publisher.none.fl_str_mv John Wiley & Sons
Society for Applied Microbiology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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