The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease

T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an import...

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Detalhes bibliográficos
Autores: Fernández-Gómez, Andrea, Izquierdo, José M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/344019
Acesso em linha:http://hdl.handle.net/10261/344019
Access Level:acceso abierto
Palavra-chave:TIA1
Gene-expression control
Cellular processes
Pathophysiological conditions
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spelling The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and DiseaseFernández-Gómez, AndreaIzquierdo, José M.TIA1Gene-expression controlCellular processesPathophysiological conditionsT-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux. As a multifunctional master modulator, TIA1 controls biological processes relevant to the physiological functioning of the organism and the development and/or progression of several human pathologies. This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology.Research in our laboratory is supported by the Ministerio de Ciencia e Innovación and Agencia Española de Investigación through FEDER funds (RTI2018-098517-B100) (MICINN/AEI/FEDER, UE). The CBMSO receives an institutional grant from Fundación Ramón Areces and Banco de Santander.Peer reviewedMolecular Diversity Preservation InternationalMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European CommissionFundación Ramón ArecesBanco SantanderConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/344019reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098517-B-I00https://doi.org/10.3390/ijms23031400Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3440192026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
title The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
spellingShingle The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
Fernández-Gómez, Andrea
TIA1
Gene-expression control
Cellular processes
Pathophysiological conditions
title_short The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
title_full The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
title_fullStr The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
title_full_unstemmed The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
title_sort The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease
dc.creator.none.fl_str_mv Fernández-Gómez, Andrea
Izquierdo, José M.
author Fernández-Gómez, Andrea
author_facet Fernández-Gómez, Andrea
Izquierdo, José M.
author_role author
author2 Izquierdo, José M.
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
European Commission
Fundación Ramón Areces
Banco Santander
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv TIA1
Gene-expression control
Cellular processes
Pathophysiological conditions
topic TIA1
Gene-expression control
Cellular processes
Pathophysiological conditions
description T-cell intracellular antigen 1 (TIA1) is an RNA-binding protein that is expressed in many tissues and in the vast majority of species, although it was first discovered as a component of human cytotoxic T lymphocytes. TIA1 has a dual localization in the nucleus and cytoplasm, where it plays an important role as a regulator of gene-expression flux. As a multifunctional master modulator, TIA1 controls biological processes relevant to the physiological functioning of the organism and the development and/or progression of several human pathologies. This review summarizes our current knowledge of the molecular aspects and cellular processes involving TIA1, with relevance for human pathophysiology.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/344019
url http://hdl.handle.net/10261/344019
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098517-B-I00
https://doi.org/10.3390/ijms23031400
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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