Clinical Features of Children With MOG-IgG Who Fulfill Criteria of Multiple Sclerosis and Overlapping Disorders

ObjectivesThe aim of this study was to report the clinical features, disease-modifying treatment (DMT) response, and outcomes of children with MOG-IgG who fulfill the 2017 McDonald criteria for multiple sclerosis (MS).MethodsThis prospective observational study included children (<18 years) with...

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Detalles Bibliográficos
Autores: Fonseca, Elianet Gisell|||0000-0002-3613-3185, Olive Cirera, Gemma, Chen, Li Wen|||0000-0002-4013-8333, Paredes-Carmona, Fernando, Vázquez-López, Mara|||0000-0002-1599-8841, Felipe-Rucián, Ana|||0000-0002-5267-1370, Romeu, Gemma, Martinez-Hernandez, Eugenia, Blanco Morgado, Yolanda|||0000-0002-1834-0498, Sepulveda, Maria, Saiz, Albert|||0000-0002-5793-8791, Dalmau, Josep|||0000-0001-5856-2813, Armangue, Thais|||0000-0001-6192-6171, Nuñez Enamorado, Noem, Boyero Duran, Sabas, Mendibe-Bilbao, María del Mar, Visa-Reñé, Nuria
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:325969
Acceso en línea:https://ddd.uab.cat/record/325969
https://dx.doi.org/urn:doi:10.1212/NXI.0000000000200400
Access Level:acceso abierto
Palabra clave:Adolescent
Autoantibodies
Child
Demyelinating Autoimmune Diseases, CNS
Female
Follow-Up Studies
Humans
Immunoglobulin G
Male
Multiple Sclerosis
Myelin-Oligodendrocyte Glycoprotein
Prospective Studies
Descripción
Sumario:ObjectivesThe aim of this study was to report the clinical features, disease-modifying treatment (DMT) response, and outcomes of children with MOG-IgG who fulfill the 2017 McDonald criteria for multiple sclerosis (MS).MethodsThis prospective observational study included children (<18 years) with a suspected acquired demyelinating syndrome (ADS) whose serum or CSF was positive for MOG-IgG, who met the indicated MS criteria, and who had ≥1 year of clinical follow-up. MOG-IgG was tested using live cell-based assays.ResultsOf 554 children with confirmed ADS (196 with MOG-IgG), 8 (median age 11 years, interquartile range 9-14) harbored MOG-IgG and fulfilled MS criteria: 2 had typical MS and 6 had overlapping MOGAD-MS features at onset, but 5 of the latter group developed an MS-like course during follow-up. Five of 7 patients with assessable samples were Epstein-Barr virus seropositive at disease onset, and all 8 had persistent silent radiologic activity with lesional location and morphology suggestive of MS, leading to initiation of DMT. All initial treatments were well tolerated, but eventually, 7 of 8 children (88%) required high-efficacy DMT.DiscussionIn this pediatric cohort, 4% of patients with MOG-IgG met criteria for MS. The clinical-radiologic spectrum ranged from typical MS to overlapping MOGAD-MS, and patients usually required high-efficacy DMT.

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