Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process

Micro/nanoplastics (MNPLs) are considered emergent pollutants widely spread over all environmental compartments. Although their potential biological effects are being intensively evaluated, many doubts remain about their potential health effects in humans. One of the most underdeveloped fields is th...

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Autores: Barguilla, Irene|||0000-0003-1081-4457, Domenech, Josefa|||0000-0003-1375-0604, Ballesteros Ribera, Sandra, Rubio Lorente, Laura|||0000-0002-2088-3803, Marcos Dauder, Ricardo|||0000-0001-7891-357X, Hernández Bonilla, Alba|||0000-0001-6938-1233
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:261064
Acceso en línea:https://ddd.uab.cat/record/261064
https://dx.doi.org/urn:doi:10.1016/j.jhazmat.2022.129470
Access Level:acceso abierto
Palabra clave:Polystyrene nanoplastic
Long-term exposure
Cell transformation
Oncogenic phenotype
Carcinogenesis
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spelling Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic processBarguilla, Irene|||0000-0003-1081-4457Domenech, Josefa|||0000-0003-1375-0604Ballesteros Ribera, SandraRubio Lorente, Laura|||0000-0002-2088-3803Marcos Dauder, Ricardo|||0000-0001-7891-357XHernández Bonilla, Alba|||0000-0001-6938-1233Polystyrene nanoplasticLong-term exposureCell transformationOncogenic phenotypeCarcinogenesisMicro/nanoplastics (MNPLs) are considered emergent pollutants widely spread over all environmental compartments. Although their potential biological effects are being intensively evaluated, many doubts remain about their potential health effects in humans. One of the most underdeveloped fields is the determination of the potential tumorigenic risk of MNPLs exposure. To shed light on this topic, we have designed a wide battery of different hallmarks of cancer applied to prone-to-transformed progress MEF cells exposed to polystyrene nanoplastics (PSNPLs) in the long term (6 months). Interestingly, most of the evaluated hallmarks of cancer are exacerbated after exposure, independently if they are associated with an early tumoral phenotype (changes in stress-related genes, or microRNA deregulation), advanced tumoral phenotype (growing independently of anchorage ability, and migration capacity), or an aggressive tumoral phenotype (invasion potential, changes in pluripotency markers, and ability to grow to form tumorspheres). This set of obtained data constitutes a relevant warning on the potential carcinogenic risk associated with long-term exposures to MNPLs, specifically that induced by the PSNPLs evaluated in this study. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/261064https://dx.doi.org/urn:doi:10.1016/j.jhazmat.2022.129470reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43European Commission https://doi.org/10.13039/501100000780 965196open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2610642026-06-06T12:50:31Z
dc.title.none.fl_str_mv Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
title Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
spellingShingle Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
Barguilla, Irene|||0000-0003-1081-4457
Polystyrene nanoplastic
Long-term exposure
Cell transformation
Oncogenic phenotype
Carcinogenesis
title_short Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
title_full Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
title_fullStr Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
title_full_unstemmed Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
title_sort Long-term exposure to nanoplastics alters molecular and functional traits related to the carcinogenic process
dc.creator.none.fl_str_mv Barguilla, Irene|||0000-0003-1081-4457
Domenech, Josefa|||0000-0003-1375-0604
Ballesteros Ribera, Sandra
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author Barguilla, Irene|||0000-0003-1081-4457
author_facet Barguilla, Irene|||0000-0003-1081-4457
Domenech, Josefa|||0000-0003-1375-0604
Ballesteros Ribera, Sandra
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author_role author
author2 Domenech, Josefa|||0000-0003-1375-0604
Ballesteros Ribera, Sandra
Rubio Lorente, Laura|||0000-0002-2088-3803
Marcos Dauder, Ricardo|||0000-0001-7891-357X
Hernández Bonilla, Alba|||0000-0001-6938-1233
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Polystyrene nanoplastic
Long-term exposure
Cell transformation
Oncogenic phenotype
Carcinogenesis
topic Polystyrene nanoplastic
Long-term exposure
Cell transformation
Oncogenic phenotype
Carcinogenesis
description Micro/nanoplastics (MNPLs) are considered emergent pollutants widely spread over all environmental compartments. Although their potential biological effects are being intensively evaluated, many doubts remain about their potential health effects in humans. One of the most underdeveloped fields is the determination of the potential tumorigenic risk of MNPLs exposure. To shed light on this topic, we have designed a wide battery of different hallmarks of cancer applied to prone-to-transformed progress MEF cells exposed to polystyrene nanoplastics (PSNPLs) in the long term (6 months). Interestingly, most of the evaluated hallmarks of cancer are exacerbated after exposure, independently if they are associated with an early tumoral phenotype (changes in stress-related genes, or microRNA deregulation), advanced tumoral phenotype (growing independently of anchorage ability, and migration capacity), or an aggressive tumoral phenotype (invasion potential, changes in pluripotency markers, and ability to grow to form tumorspheres). This set of obtained data constitutes a relevant warning on the potential carcinogenic risk associated with long-term exposures to MNPLs, specifically that induced by the PSNPLs evaluated in this study.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/261064
https://dx.doi.org/urn:doi:10.1016/j.jhazmat.2022.129470
url https://ddd.uab.cat/record/261064
https://dx.doi.org/urn:doi:10.1016/j.jhazmat.2022.129470
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-116789RB-C43
European Commission https://doi.org/10.13039/501100000780 965196
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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