Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults

Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramid...

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Autores: Cipriani, Sara, Ferrer, Isidro (Ferrer Abizanda), Aronica, Eleonora, Kovacs, Gabor G., Verney, Catherine, Nardelli, Jeannette, Khung, Suonavy, Delezoide, Anne-Lise, Milenkovic, Ivan, Rasika, Sowmyalakshmi, Manivet, Philippe, Benifla, Jean-Louis, Deriot, Nicolas, Gressens, Pierre, Adle-Bissette, Homa
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2018
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/140476
Acesso em linha:https://hdl.handle.net/2445/140476
Access Level:Acceso aberto
Palavra-chave:Neurogenètica
Hipocamp (Cervell)
Malaltia d'Alzheimer
Neurogenetics
Hippocampus (Brain)
Alzheimer's disease
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spelling Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adultsCipriani, SaraFerrer, Isidro (Ferrer Abizanda)Aronica, EleonoraKovacs, Gabor G.Verney, CatherineNardelli, JeannetteKhung, SuonavyDelezoide, Anne-LiseMilenkovic, IvanRasika, SowmyalakshmiManivet, PhilippeBenifla, Jean-LouisDeriot, NicolasGressens, PierreAdle-Bissette, HomaNeurogenèticaHipocamp (Cervell)Malaltia d'AlzheimerNeurogeneticsHippocampus (Brain)Alzheimer's diseaseNeuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult. Key words: adult neurogenesis, hippocampus, human fetal brain, neurogenesis, radial glial cellsOxford University Press2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/140476Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1093/cercor/bhy096Cerebral Cortex, 2018, vol. 28, num. 7, p. 2458-2478https://doi.org/10.1093/cercor/bhy096(c) Cipriani, Sara et al., 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1404762026-05-27T06:46:51Z
dc.title.none.fl_str_mv Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
title Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
spellingShingle Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
Cipriani, Sara
Neurogenètica
Hipocamp (Cervell)
Malaltia d'Alzheimer
Neurogenetics
Hippocampus (Brain)
Alzheimer's disease
title_short Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
title_full Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
title_fullStr Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
title_full_unstemmed Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
title_sort Hippocampal radial glial subtypes and their neurogenic potential in human fetuses and healthy and Alzheimer's disease adults
dc.creator.none.fl_str_mv Cipriani, Sara
Ferrer, Isidro (Ferrer Abizanda)
Aronica, Eleonora
Kovacs, Gabor G.
Verney, Catherine
Nardelli, Jeannette
Khung, Suonavy
Delezoide, Anne-Lise
Milenkovic, Ivan
Rasika, Sowmyalakshmi
Manivet, Philippe
Benifla, Jean-Louis
Deriot, Nicolas
Gressens, Pierre
Adle-Bissette, Homa
author Cipriani, Sara
author_facet Cipriani, Sara
Ferrer, Isidro (Ferrer Abizanda)
Aronica, Eleonora
Kovacs, Gabor G.
Verney, Catherine
Nardelli, Jeannette
Khung, Suonavy
Delezoide, Anne-Lise
Milenkovic, Ivan
Rasika, Sowmyalakshmi
Manivet, Philippe
Benifla, Jean-Louis
Deriot, Nicolas
Gressens, Pierre
Adle-Bissette, Homa
author_role author
author2 Ferrer, Isidro (Ferrer Abizanda)
Aronica, Eleonora
Kovacs, Gabor G.
Verney, Catherine
Nardelli, Jeannette
Khung, Suonavy
Delezoide, Anne-Lise
Milenkovic, Ivan
Rasika, Sowmyalakshmi
Manivet, Philippe
Benifla, Jean-Louis
Deriot, Nicolas
Gressens, Pierre
Adle-Bissette, Homa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurogenètica
Hipocamp (Cervell)
Malaltia d'Alzheimer
Neurogenetics
Hippocampus (Brain)
Alzheimer's disease
topic Neurogenètica
Hipocamp (Cervell)
Malaltia d'Alzheimer
Neurogenetics
Hippocampus (Brain)
Alzheimer's disease
description Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult. Key words: adult neurogenesis, hippocampus, human fetal brain, neurogenesis, radial glial cells
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140476
url https://hdl.handle.net/2445/140476
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1093/cercor/bhy096
Cerebral Cortex, 2018, vol. 28, num. 7, p. 2458-2478
https://doi.org/10.1093/cercor/bhy096
dc.rights.none.fl_str_mv (c) Cipriani, Sara et al., 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cipriani, Sara et al., 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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