A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics

Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of an individual have to be taken into account as well as a series of omics markers....

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Detalhes bibliográficos
Autores: Corella, Dolores, Coltell, Oscar, Portolés, Olga, Sotos-Prieto, Mercedes, Fernández-Carrión, Rebeca, Ramirez-Sabio, Judith B, Zanón-Moreno, Vicente, Mattei, Josiemer, Sorlí, José V, Ordovas, Jose M
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7207
Acesso em linha:http://hdl.handle.net/20.500.12105/7207
Access Level:acceso abierto
Palavra-chave:Diet
Female
Gender Identity
Humans
Male
Nutrigenomics
Nutritional Physiological Phenomena
Nutritional Status
Phenotype
Precision Medicine
Sex Characteristics
Sex Factors
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spelling A Guide to Applying the Sex-Gender Perspective to Nutritional GenomicsCorella, DoloresColtell, OscarPortolés, OlgaSotos-Prieto, MercedesFernández-Carrión, RebecaRamirez-Sabio, Judith BZanón-Moreno, VicenteMattei, JosiemerSorlí, José VOrdovas, Jose MDietFemaleGender IdentityHumansMaleNutrigenomicsNutritional Physiological PhenomenaNutritional StatusPhenotypePrecision MedicineSex CharacteristicsSex FactorsPrecision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of an individual have to be taken into account as well as a series of omics markers. The results of nutritional genomics studies are crucial to generate the evidence needed so that precision nutrition can be applied. Although sex is one of the fundamental variables for making recommendations, at present, the nutritional genomics studies undertaken have not analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet interactions on the different phenotypes studied, thus there is little information available on this issue and needs to be improved. Here we argue for the need to incorporate the gender perspective in nutritional genomics studies, present the general context, analyze the differences between sex and gender, as well as the limitations to measuring them and to detecting specific sex-gene or sex-phenotype associations, both at the specific gene level or in genome-wide-association studies. We analyzed the main sex-specific gene-diet interactions published to date and their main limitations and present guidelines with recommendations to be followed when undertaking new nutritional genomics studies incorporating the gender perspective.Multidisciplinary Digital Publishing Institute (MDPI)Ministerio de Sanidad, Consumo y Bienestar Social (España)Ministerio de Economía y Competitividad (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Fundación La Marató TV3Generalitat Valenciana (España)Jaume I University (España)United States Department of AgricultureCentro de Investigación Biomedica en Red - CIBER20192019-02-2120182018-12-2020182018-12-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7207reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PRX17 00500ES PI16 00366ES PI06 1326ES SAF2016-80532-R Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/72072026-06-12T12:43:37Z
dc.title.none.fl_str_mv A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
title A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
spellingShingle A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
Corella, Dolores
Diet
Female
Gender Identity
Humans
Male
Nutrigenomics
Nutritional Physiological Phenomena
Nutritional Status
Phenotype
Precision Medicine
Sex Characteristics
Sex Factors
title_short A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
title_full A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
title_fullStr A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
title_full_unstemmed A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
title_sort A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
dc.creator.none.fl_str_mv Corella, Dolores
Coltell, Oscar
Portolés, Olga
Sotos-Prieto, Mercedes
Fernández-Carrión, Rebeca
Ramirez-Sabio, Judith B
Zanón-Moreno, Vicente
Mattei, Josiemer
Sorlí, José V
Ordovas, Jose M
author Corella, Dolores
author_facet Corella, Dolores
Coltell, Oscar
Portolés, Olga
Sotos-Prieto, Mercedes
Fernández-Carrión, Rebeca
Ramirez-Sabio, Judith B
Zanón-Moreno, Vicente
Mattei, Josiemer
Sorlí, José V
Ordovas, Jose M
author_role author
author2 Coltell, Oscar
Portolés, Olga
Sotos-Prieto, Mercedes
Fernández-Carrión, Rebeca
Ramirez-Sabio, Judith B
Zanón-Moreno, Vicente
Mattei, Josiemer
Sorlí, José V
Ordovas, Jose M
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Sanidad, Consumo y Bienestar Social (España)
Ministerio de Economía y Competitividad (España)
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Fundación La Marató TV3
Generalitat Valenciana (España)
Jaume I University (España)
United States Department of Agriculture
Centro de Investigación Biomedica en Red - CIBER
dc.subject.none.fl_str_mv Diet
Female
Gender Identity
Humans
Male
Nutrigenomics
Nutritional Physiological Phenomena
Nutritional Status
Phenotype
Precision Medicine
Sex Characteristics
Sex Factors
topic Diet
Female
Gender Identity
Humans
Male
Nutrigenomics
Nutritional Physiological Phenomena
Nutritional Status
Phenotype
Precision Medicine
Sex Characteristics
Sex Factors
description Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of an individual have to be taken into account as well as a series of omics markers. The results of nutritional genomics studies are crucial to generate the evidence needed so that precision nutrition can be applied. Although sex is one of the fundamental variables for making recommendations, at present, the nutritional genomics studies undertaken have not analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet interactions on the different phenotypes studied, thus there is little information available on this issue and needs to be improved. Here we argue for the need to incorporate the gender perspective in nutritional genomics studies, present the general context, analyze the differences between sex and gender, as well as the limitations to measuring them and to detecting specific sex-gene or sex-phenotype associations, both at the specific gene level or in genome-wide-association studies. We analyzed the main sex-specific gene-diet interactions published to date and their main limitations and present guidelines with recommendations to be followed when undertaking new nutritional genomics studies incorporating the gender perspective.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-12-20
2018
2018-12-20
2019
2019-02-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7207
url http://hdl.handle.net/20.500.12105/7207
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PRX17 00500
ES PI16 00366
ES PI06 1326
ES SAF2016-80532-R Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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