Molecular nanogels as nanocarriers. Intracellular transport of photosensitizers and nitric oxide probes
The preparation of molecular nanogels is reported in this thesis. These new nanoparticles, formed by low molecular weight gelators, represent an exciting alternative to their polymeric counterparts considering their intrinsic characteristics (fully reversible stimuli-regulated assembly, easy biodegr...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/671255 |
| Acceso en línea: | http://hdl.handle.net/10803/671255 http://dx.doi.org/10.6035/14104.2021.368244 |
| Access Level: | acceso abierto |
| Palabra clave: | Molecular nanogels Nanocarriers Molecular lipogels Photodynamic therapy Nitric oxide probes Ciències naturals, químiques, físiques i matemàtiques 547 |
| Sumario: | The preparation of molecular nanogels is reported in this thesis. These new nanoparticles, formed by low molecular weight gelators, represent an exciting alternative to their polymeric counterparts considering their intrinsic characteristics (fully reversible stimuli-regulated assembly, easy biodegradation, excellent biocompatibility and tailored properties). Novel hydrogel@liposome particles were also obtained by molecular gel formation inside liposomes, merging the benefits of liposomal vehicles with the inherent characteristics of molecular gels. The capability of molecular nanogels to incorporate and release actives and act as intracellular carriers was demonstrated, improving the efficiency of photoactive molecules in their biomedical use. Photosensitizers (Rose Bengal and hypericin) showed enhanced cellular uptake and improved performance in photodynamic therapy for cancer. The encapsulation in the nanogels of nitric oxide probes lead to an enhanced cellular uptake of DAF-2 and an increased solubility in water of DAQ. |
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