Genome-wide diversity in the levant reveals recent structuring by culture
The Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing the Middle East and the Arabian Peninsula as the first stepping-stone outside...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2013 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/23440 |
| Acesso em linha: | http://hdl.handle.net/10230/23440 http://dx.doi.org/10.1371/journal.pgen.1003316 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Genètica de poblacions ADN mitocondrial -- Genètica Cromosomes humans |
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Genome-wide diversity in the levant reveals recent structuring by cultureHaber, Marc, 1980-Gauguier, DominiqueYouhanna, SoniaPatterson, NickMoorjani, PriyaBotigué, Laura R.Platt, Daniel E.Matisoo Smith, ElizabethSoria Hernanz, David FWells, R. SpencerBertranpetit, Jaume, 1952-Tyler-Smith, ChrisComas, David, 1969-Zalloua, Pierre A.Genètica de poblacionsADN mitocondrial -- GenèticaCromosomes humansThe Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing the Middle East and the Arabian Peninsula as the first stepping-stone outside Africa. There is, however, little understanding of demographic changes in the Middle East, particularly the Levant, after the first Out-of-Africa expansion and how the Levantine peoples relate genetically to each other and to their neighbors. In this study we analyze more than 500,000 genome-wide SNPs in 1,341 new samples from the Levant and compare them to samples from 48 populations worldwide. Our results show recent genetic stratifications in the Levant are driven by the religious affiliations of the populations within the region. Cultural changes within the last two millennia appear to have facilitated/maintained admixture between culturally similar populations from the Levant, Arabian Peninsula, and Africa. The same cultural changes seem to have resulted in genetic isolation of other groups by limiting admixture with culturally different neighboring populations. Consequently, Levant populations today fall into two main groups: one sharing more genetic characteristics with modern-day Europeans and Central Asians, and the other with closer genetic affinities to other Middle Easterners and Africans. Finally, we identify a putative Levantine ancestral component that diverged from other Middle Easterners 23,700–15,500 years ago during the last glacial period, and diverged from Europeans 15,900–9,100 years ago between the last glacial warming and the start of the NeolithicThis study was partly supported by the Lebanese American University and the National Geographic Society (The Genographic Project). CT-S was supported by grant number 098051 from The Wellcome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptPublic Library of Science (PLoS)201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23440http://dx.doi.org/10.1371/journal.pgen.1003316reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPLoS Genetics. 2013;9(2):e1003316info:eu-repo/grantAgreement/EC/FP7/098051© Haber et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/234402026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Genome-wide diversity in the levant reveals recent structuring by culture |
| title |
Genome-wide diversity in the levant reveals recent structuring by culture |
| spellingShingle |
Genome-wide diversity in the levant reveals recent structuring by culture Haber, Marc, 1980- Genètica de poblacions ADN mitocondrial -- Genètica Cromosomes humans |
| title_short |
Genome-wide diversity in the levant reveals recent structuring by culture |
| title_full |
Genome-wide diversity in the levant reveals recent structuring by culture |
| title_fullStr |
Genome-wide diversity in the levant reveals recent structuring by culture |
| title_full_unstemmed |
Genome-wide diversity in the levant reveals recent structuring by culture |
| title_sort |
Genome-wide diversity in the levant reveals recent structuring by culture |
| dc.creator.none.fl_str_mv |
Haber, Marc, 1980- Gauguier, Dominique Youhanna, Sonia Patterson, Nick Moorjani, Priya Botigué, Laura R. Platt, Daniel E. Matisoo Smith, Elizabeth Soria Hernanz, David F Wells, R. Spencer Bertranpetit, Jaume, 1952- Tyler-Smith, Chris Comas, David, 1969- Zalloua, Pierre A. |
| author |
Haber, Marc, 1980- |
| author_facet |
Haber, Marc, 1980- Gauguier, Dominique Youhanna, Sonia Patterson, Nick Moorjani, Priya Botigué, Laura R. Platt, Daniel E. Matisoo Smith, Elizabeth Soria Hernanz, David F Wells, R. Spencer Bertranpetit, Jaume, 1952- Tyler-Smith, Chris Comas, David, 1969- Zalloua, Pierre A. |
| author_role |
author |
| author2 |
Gauguier, Dominique Youhanna, Sonia Patterson, Nick Moorjani, Priya Botigué, Laura R. Platt, Daniel E. Matisoo Smith, Elizabeth Soria Hernanz, David F Wells, R. Spencer Bertranpetit, Jaume, 1952- Tyler-Smith, Chris Comas, David, 1969- Zalloua, Pierre A. |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Genètica de poblacions ADN mitocondrial -- Genètica Cromosomes humans |
| topic |
Genètica de poblacions ADN mitocondrial -- Genètica Cromosomes humans |
| description |
The Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing the Middle East and the Arabian Peninsula as the first stepping-stone outside Africa. There is, however, little understanding of demographic changes in the Middle East, particularly the Levant, after the first Out-of-Africa expansion and how the Levantine peoples relate genetically to each other and to their neighbors. In this study we analyze more than 500,000 genome-wide SNPs in 1,341 new samples from the Levant and compare them to samples from 48 populations worldwide. Our results show recent genetic stratifications in the Levant are driven by the religious affiliations of the populations within the region. Cultural changes within the last two millennia appear to have facilitated/maintained admixture between culturally similar populations from the Levant, Arabian Peninsula, and Africa. The same cultural changes seem to have resulted in genetic isolation of other groups by limiting admixture with culturally different neighboring populations. Consequently, Levant populations today fall into two main groups: one sharing more genetic characteristics with modern-day Europeans and Central Asians, and the other with closer genetic affinities to other Middle Easterners and Africans. Finally, we identify a putative Levantine ancestral component that diverged from other Middle Easterners 23,700–15,500 years ago during the last glacial period, and diverged from Europeans 15,900–9,100 years ago between the last glacial warming and the start of the Neolithic |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2015 2015 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/23440 http://dx.doi.org/10.1371/journal.pgen.1003316 |
| url |
http://hdl.handle.net/10230/23440 http://dx.doi.org/10.1371/journal.pgen.1003316 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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PLoS Genetics. 2013;9(2):e1003316 info:eu-repo/grantAgreement/EC/FP7/098051 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
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Public Library of Science (PLoS) |
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Public Library of Science (PLoS) |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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