Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/114901 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/114901 |
| Access Level: | acceso abierto |
| Palabra clave: | 617.7:616.9 617.7-007.681 577.15.013 547:617.7-08 ganglion cells coenzyme Q10 Brn3a melanopsin neuroprotection citicoline experimental glaucoma visual pathway retina Oftalmología Neurociencias (Medicina) Química orgánica (Farmacia) 3201.09 Oftalmología 3207.11 Neuropatología 2306 Química Orgánica |
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Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular HypertensionMatamoros Felipe, José AntonioRubio-Casado, SaraFernández Albarral, JoséMartínez López, Miguel ÁngelGarcía Martín, Elena SalobrarMarco López, Eva MaríaPaleo-García, VíctorHoz Montañana, María Rosa DeLópez Cuenca, InésElvira-Hurtado, LorenaSánchez-Puebla Fernández, LidiaRamírez Sebastián, José ManuelSalazar Corral, Juan JoséLópez Gallardo, MeritxellRamírez Sebastián, Ana Isabel617.7:616.9617.7-007.681577.15.013547:617.7-08ganglion cellscoenzyme Q10Brn3amelanopsinneuroprotectionciticolineexperimental glaucomavisual pathwayretinaOftalmologíaNeurociencias (Medicina)Química orgánica (Farmacia)3201.09 Oftalmología3207.11 Neuropatología2306 Química OrgánicaGlaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (n = 6), citicoline + CoQ10 group (n = 6), laser–vehicle group (n = 6), and laser–citicoline + CoQ10 group (n = 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser–citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT.MDPIUniversidad Complutense de Madrid20242024-12-2420242024-12-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/114901reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1149012026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| title |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| spellingShingle |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension Matamoros Felipe, José Antonio 617.7:616.9 617.7-007.681 577.15.013 547:617.7-08 ganglion cells coenzyme Q10 Brn3a melanopsin neuroprotection citicoline experimental glaucoma visual pathway retina Oftalmología Neurociencias (Medicina) Química orgánica (Farmacia) 3201.09 Oftalmología 3207.11 Neuropatología 2306 Química Orgánica |
| title_short |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| title_full |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| title_fullStr |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| title_full_unstemmed |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| title_sort |
Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension |
| dc.creator.none.fl_str_mv |
Matamoros Felipe, José Antonio Rubio-Casado, Sara Fernández Albarral, José Martínez López, Miguel Ángel García Martín, Elena Salobrar Marco López, Eva María Paleo-García, Víctor Hoz Montañana, María Rosa De López Cuenca, Inés Elvira-Hurtado, Lorena Sánchez-Puebla Fernández, Lidia Ramírez Sebastián, José Manuel Salazar Corral, Juan José López Gallardo, Meritxell Ramírez Sebastián, Ana Isabel |
| author |
Matamoros Felipe, José Antonio |
| author_facet |
Matamoros Felipe, José Antonio Rubio-Casado, Sara Fernández Albarral, José Martínez López, Miguel Ángel García Martín, Elena Salobrar Marco López, Eva María Paleo-García, Víctor Hoz Montañana, María Rosa De López Cuenca, Inés Elvira-Hurtado, Lorena Sánchez-Puebla Fernández, Lidia Ramírez Sebastián, José Manuel Salazar Corral, Juan José López Gallardo, Meritxell Ramírez Sebastián, Ana Isabel |
| author_role |
author |
| author2 |
Rubio-Casado, Sara Fernández Albarral, José Martínez López, Miguel Ángel García Martín, Elena Salobrar Marco López, Eva María Paleo-García, Víctor Hoz Montañana, María Rosa De López Cuenca, Inés Elvira-Hurtado, Lorena Sánchez-Puebla Fernández, Lidia Ramírez Sebastián, José Manuel Salazar Corral, Juan José López Gallardo, Meritxell Ramírez Sebastián, Ana Isabel |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
617.7:616.9 617.7-007.681 577.15.013 547:617.7-08 ganglion cells coenzyme Q10 Brn3a melanopsin neuroprotection citicoline experimental glaucoma visual pathway retina Oftalmología Neurociencias (Medicina) Química orgánica (Farmacia) 3201.09 Oftalmología 3207.11 Neuropatología 2306 Química Orgánica |
| topic |
617.7:616.9 617.7-007.681 577.15.013 547:617.7-08 ganglion cells coenzyme Q10 Brn3a melanopsin neuroprotection citicoline experimental glaucoma visual pathway retina Oftalmología Neurociencias (Medicina) Química orgánica (Farmacia) 3201.09 Oftalmología 3207.11 Neuropatología 2306 Química Orgánica |
| description |
Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (n = 6), citicoline + CoQ10 group (n = 6), laser–vehicle group (n = 6), and laser–citicoline + CoQ10 group (n = 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser–citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-12-24 2024 2024-12-24 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/114901 |
| url |
https://hdl.handle.net/20.500.14352/114901 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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