Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.

BACKGROUND: Evidence for a relationship between trihalomethane (THM) or haloacetic acid (HAA) exposure and adverse fetal growth is inconsistent. Disinfection by-products exist as complex mixtures in water supplies, but THMs and HAAs have typically been examined separately. OBJECTIVES: We investigate...

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Autores: Smith, Rachel B., Edward, Susan C., Best, Nicky, Wright, John, Nieuwenhuijsen, Mark J., Toledano, Mireille B.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/26254
Acceso en línea:http://hdl.handle.net/10230/26254
http://dx.doi.org/10.1289/ehp.1409480
Access Level:acceso abierto
Palabra clave:Aigua -- Qualitat
Embaràs
Fetus -- Malalties
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repository_id_str
spelling Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.Smith, Rachel B.Edward, Susan C.Best, NickyWright, JohnNieuwenhuijsen, Mark J.Toledano, Mireille B.Aigua -- QualitatEmbaràsFetus -- MalaltiesBACKGROUND: Evidence for a relationship between trihalomethane (THM) or haloacetic acid (HAA) exposure and adverse fetal growth is inconsistent. Disinfection by-products exist as complex mixtures in water supplies, but THMs and HAAs have typically been examined separately. OBJECTIVES: We investigated joint exposure at the individual level to THMs and HAAs in relation to birth weight in the multi-ethnic Born in Bradford birth cohort. METHODS: Pregnant women reported their water consumption and activities via questionnaire. These data were combined with area-level THM and HAA oncentrations to estimate integrated uptake of THMs into blood and HAA ingestion, accounting for boiling/filtering. We examined the relationship between THM and HAA exposures and birth weight of up to 7,438 singleton term babies using multiple linear regression, stratified by ethnicity. RESULTS: Among Pakistani-origin infants, mean birth weight was significantly lower in association with the highest versus lowest tertiles of integrated THM uptake (e.g., -53.7 g; 95% CI: -89.9, -17.5 for ≥ 1.82 vs. < 1.05 μg/day of total THM) and there were significant trends (p < 0.01) across increasing tertiles, but there were no associations among white British infants. Neither ingestion of HAAs alone or jointly with THMs was associated with birth weight. Estimated THM uptake via showering, bathing, and swimming was significantly associated with lower birth weight in Pakistani-origin infants, when adjusting for THM and HAA ingestion via water consumption. CONCLUSIONS: To our knowledge, this is the largest DBP and fetal growth study to date with individual water use data, and the first to examine individual-level estimates of joint THM-HAA exposure. Our findings demonstrate associations between THM, but not HAA, exposure during pregnancy and reduced birth weight, but suggest this differs by ethnicity. This study suggests that THMs are not acting as a proxy for HAAs, or vice-versa.This research was funded by HiWATE (Health Impacts of Long-Term Exposure to Disinfection By-products in Drinking Water in Europe) (EU 6th Framework Programme contract no. Food-CT-2006-036224), the Joint Environment & Human Health Programme (NERC grant NE/ E008844/1), an Economic and Social Research Council studentship (PTA-031-2006-00544 to R.B.S.), an MRC Capacity Building Studentship 2010-2013 to S.C.E., and a Research Training support stipend (S.C.E.). The MRC-PHE Centre for Environment and Health is funded by the UK Medical Research Council and Public Health EnglandNational Institute of Environmental Health Sciences201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26254http://dx.doi.org/10.1289/ehp.1409480reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2016 May;124(5):681-9info:eu-repo/grantAgreement/EC/FP6/036224Reproduced wiht permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/262542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
title Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
spellingShingle Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
Smith, Rachel B.
Aigua -- Qualitat
Embaràs
Fetus -- Malalties
title_short Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
title_full Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
title_fullStr Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
title_full_unstemmed Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
title_sort Birth weight, ethnicity, and exposure to trihalomethanes and haloacetic acids in drinking water during pregnancy in the born in bradford cohort.
dc.creator.none.fl_str_mv Smith, Rachel B.
Edward, Susan C.
Best, Nicky
Wright, John
Nieuwenhuijsen, Mark J.
Toledano, Mireille B.
author Smith, Rachel B.
author_facet Smith, Rachel B.
Edward, Susan C.
Best, Nicky
Wright, John
Nieuwenhuijsen, Mark J.
Toledano, Mireille B.
author_role author
author2 Edward, Susan C.
Best, Nicky
Wright, John
Nieuwenhuijsen, Mark J.
Toledano, Mireille B.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Aigua -- Qualitat
Embaràs
Fetus -- Malalties
topic Aigua -- Qualitat
Embaràs
Fetus -- Malalties
description BACKGROUND: Evidence for a relationship between trihalomethane (THM) or haloacetic acid (HAA) exposure and adverse fetal growth is inconsistent. Disinfection by-products exist as complex mixtures in water supplies, but THMs and HAAs have typically been examined separately. OBJECTIVES: We investigated joint exposure at the individual level to THMs and HAAs in relation to birth weight in the multi-ethnic Born in Bradford birth cohort. METHODS: Pregnant women reported their water consumption and activities via questionnaire. These data were combined with area-level THM and HAA oncentrations to estimate integrated uptake of THMs into blood and HAA ingestion, accounting for boiling/filtering. We examined the relationship between THM and HAA exposures and birth weight of up to 7,438 singleton term babies using multiple linear regression, stratified by ethnicity. RESULTS: Among Pakistani-origin infants, mean birth weight was significantly lower in association with the highest versus lowest tertiles of integrated THM uptake (e.g., -53.7 g; 95% CI: -89.9, -17.5 for ≥ 1.82 vs. < 1.05 μg/day of total THM) and there were significant trends (p < 0.01) across increasing tertiles, but there were no associations among white British infants. Neither ingestion of HAAs alone or jointly with THMs was associated with birth weight. Estimated THM uptake via showering, bathing, and swimming was significantly associated with lower birth weight in Pakistani-origin infants, when adjusting for THM and HAA ingestion via water consumption. CONCLUSIONS: To our knowledge, this is the largest DBP and fetal growth study to date with individual water use data, and the first to examine individual-level estimates of joint THM-HAA exposure. Our findings demonstrate associations between THM, but not HAA, exposure during pregnancy and reduced birth weight, but suggest this differs by ethnicity. This study suggests that THMs are not acting as a proxy for HAAs, or vice-versa.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26254
http://dx.doi.org/10.1289/ehp.1409480
url http://hdl.handle.net/10230/26254
http://dx.doi.org/10.1289/ehp.1409480
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2016 May;124(5):681-9
info:eu-repo/grantAgreement/EC/FP6/036224
dc.rights.none.fl_str_mv Reproduced wiht permission from Environmental Health Perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced wiht permission from Environmental Health Perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences
publisher.none.fl_str_mv National Institute of Environmental Health Sciences
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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