Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons for which effective therapies are lacking. One of the most explored areas of research in ALS is the discovery and validation of biomarkers that can be applied to clinical practice and inco...

Full description

Bibliographic Details
Authors: Sánchez-Tejerina, Daniel|||0000-0002-5624-638X, Llauradó, Arnau|||0000-0002-4655-6157, Sotoca Fernández, Javier|||0000-0003-3400-1434, Lopez-Diego, Veronica, Vidal-Taboada, Jose Manuel|||0000-0001-5667-4133, Salvado, Maria|||0000-0002-1526-1903, Juntas Morales, Raúl|||0000-0003-2205-1741
Format: article
Publication Date:2023
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:281652
Online Access:https://ddd.uab.cat/record/281652
https://dx.doi.org/urn:doi:10.3390/cells12081180
Access Level:Open access
Keyword:Amyotrophic lateral sclerosis (ALS)
Biomarker
Genetics
Neuroinflammation
Neurofilament light (NfL) protein
Pharmacodynamic biomarker
Prognosis
id ES_0d3e9ecc3169cea2ef0b81e340eece2e
oai_identifier_str oai:ddd.uab.cat:281652
network_acronym_str ES
network_name_str España
repository_id_str
spelling Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral SclerosisRecent Developments and Therapeutic ApplicationsSánchez-Tejerina, Daniel|||0000-0002-5624-638XLlauradó, Arnau|||0000-0002-4655-6157Sotoca Fernández, Javier|||0000-0003-3400-1434Lopez-Diego, VeronicaVidal-Taboada, Jose Manuel|||0000-0001-5667-4133Salvado, Maria|||0000-0002-1526-1903Juntas Morales, Raúl|||0000-0003-2205-1741Amyotrophic lateral sclerosis (ALS)BiomarkerGeneticsNeuroinflammationNeurofilament light (NfL) proteinPharmacodynamic biomarkerPrognosisAmyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons for which effective therapies are lacking. One of the most explored areas of research in ALS is the discovery and validation of biomarkers that can be applied to clinical practice and incorporated into the development of innovative therapies. The study of biomarkers requires an adequate theoretical and operational framework, highlighting the "fit-for-purpose" concept and distinguishing different types of biomarkers based on common terminology. In this review, we aim to discuss the current status of fluid-based prognostic and predictive biomarkers in ALS, with particular emphasis on those that are the most promising ones for clinical trial design and routine clinical practice. Neurofilaments in cerebrospinal fluid and blood are the main prognostic and pharmacodynamic biomarkers. Furthermore, several candidates exist covering various pathological aspects of the disease, such as immune, metabolic and muscle damage markers. Urine has been studied less often and should be explored for its possible advantages. New advances in the knowledge of cryptic exons introduce the possibility of discovering new biomarkers. Collaborative efforts, prospective studies and standardized procedures are needed to validate candidate biomarkers. A combined biomarkers panel can provide a more detailed disease status.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281652https://dx.doi.org/urn:doi:10.3390/cells12081180reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2816522026-06-06T12:50:31Z
dc.title.none.fl_str_mv Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
Recent Developments and Therapeutic Applications
title Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
spellingShingle Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
Sánchez-Tejerina, Daniel|||0000-0002-5624-638X
Amyotrophic lateral sclerosis (ALS)
Biomarker
Genetics
Neuroinflammation
Neurofilament light (NfL) protein
Pharmacodynamic biomarker
Prognosis
title_short Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
title_full Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
title_fullStr Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
title_full_unstemmed Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
title_sort Biofluid Biomarkers in the Prognosis of Amyotrophic Lateral Sclerosis
dc.creator.none.fl_str_mv Sánchez-Tejerina, Daniel|||0000-0002-5624-638X
Llauradó, Arnau|||0000-0002-4655-6157
Sotoca Fernández, Javier|||0000-0003-3400-1434
Lopez-Diego, Veronica
Vidal-Taboada, Jose Manuel|||0000-0001-5667-4133
Salvado, Maria|||0000-0002-1526-1903
Juntas Morales, Raúl|||0000-0003-2205-1741
author Sánchez-Tejerina, Daniel|||0000-0002-5624-638X
author_facet Sánchez-Tejerina, Daniel|||0000-0002-5624-638X
Llauradó, Arnau|||0000-0002-4655-6157
Sotoca Fernández, Javier|||0000-0003-3400-1434
Lopez-Diego, Veronica
Vidal-Taboada, Jose Manuel|||0000-0001-5667-4133
Salvado, Maria|||0000-0002-1526-1903
Juntas Morales, Raúl|||0000-0003-2205-1741
author_role author
author2 Llauradó, Arnau|||0000-0002-4655-6157
Sotoca Fernández, Javier|||0000-0003-3400-1434
Lopez-Diego, Veronica
Vidal-Taboada, Jose Manuel|||0000-0001-5667-4133
Salvado, Maria|||0000-0002-1526-1903
Juntas Morales, Raúl|||0000-0003-2205-1741
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Amyotrophic lateral sclerosis (ALS)
Biomarker
Genetics
Neuroinflammation
Neurofilament light (NfL) protein
Pharmacodynamic biomarker
Prognosis
topic Amyotrophic lateral sclerosis (ALS)
Biomarker
Genetics
Neuroinflammation
Neurofilament light (NfL) protein
Pharmacodynamic biomarker
Prognosis
description Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the degeneration of motor neurons for which effective therapies are lacking. One of the most explored areas of research in ALS is the discovery and validation of biomarkers that can be applied to clinical practice and incorporated into the development of innovative therapies. The study of biomarkers requires an adequate theoretical and operational framework, highlighting the "fit-for-purpose" concept and distinguishing different types of biomarkers based on common terminology. In this review, we aim to discuss the current status of fluid-based prognostic and predictive biomarkers in ALS, with particular emphasis on those that are the most promising ones for clinical trial design and routine clinical practice. Neurofilaments in cerebrospinal fluid and blood are the main prognostic and pharmacodynamic biomarkers. Furthermore, several candidates exist covering various pathological aspects of the disease, such as immune, metabolic and muscle damage markers. Urine has been studied less often and should be explored for its possible advantages. New advances in the knowledge of cryptic exons introduce the possibility of discovering new biomarkers. Collaborative efforts, prospective studies and standardized procedures are needed to validate candidate biomarkers. A combined biomarkers panel can provide a more detailed disease status.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281652
https://dx.doi.org/urn:doi:10.3390/cells12081180
url https://ddd.uab.cat/record/281652
https://dx.doi.org/urn:doi:10.3390/cells12081180
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403329266712576
score 15,300719

Similar Items