Lung ultrasound and biomarkers in primary care
The association of pulmonary congestion assessed by lung ultrasound (LUS) and biomarkers-other than N-terminal pro-brain natriuretic peptide (NT-proBNP)-is uncertain. We investigated the relationship between total B-line count by LUS and several biomarkers in outpatients with suspicion of heart fail...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:237945 |
| Acceso en línea: | https://ddd.uab.cat/record/237945 https://dx.doi.org/urn:doi:10.33393/jcb.2020.2164 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomarkers Congestion Diagnosis Heart failure Lung ultrasound Primary care |
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Lung ultrasound and biomarkers in primary carePartners for a better management of patients with heart failure?Domingo, Mar|||0000-0002-2935-1272Conangla, Laura|||0000-0002-6102-3033Lupón, Josep|||0000-0002-5601-9611Wilke, AsunciónJuncà Puig, Gladys|||0000-0002-4421-5658Revuelta-López, Elena|||0000-0001-8962-5936Tejedor, XavierBayés-Genís, Antoni|||0000-0002-3044-197XBiomarkersCongestionDiagnosisHeart failureLung ultrasoundPrimary careThe association of pulmonary congestion assessed by lung ultrasound (LUS) and biomarkers-other than N-terminal pro-brain natriuretic peptide (NT-proBNP)-is uncertain. We investigated the relationship between total B-line count by LUS and several biomarkers in outpatients with suspicion of heart failure (HF). Primary care patients with suspected new-onset nonacute HF were evaluated both with a 12-scan LUS protocol (8 anterolateral areas plus 4 lower posterior thoracic areas) and 11 inflammatory and cardiovascular biomarkers. A cardiologist blinded to LUS and biomarkers except NT-proBNP confirmed HF diagnosis. After log-transformation of biomarkers' concentrations, unadjusted and adjusted correlations were performed. A total of 170 patients were included (age 76 ± 10 years, 67.6% women). HF diagnosis was confirmed in 38 (22.4%) patients. After adjustment by age, sex, body mass index, and renal function, total B-line sum significantly correlated with NT-proBNP (R = 0.29, p < 0.001), growth/differentiation factor-15 (GDF-15; R = 0.23, p = 0.003), high-sensitive Troponin T (hsTnT; R = 0.36, p < 0.001), soluble interleukin-1 receptor-like 1 (sST2; R = 0.29, p < 0.001), cancer antigen 125 (CA-125; R = 0.17, p = 0.03), high-sensitivity C-reactive protein (hsCRP; R = 0.20, p = 0.009), and interleukin (IL)-6 (R = 0.23, p = 0.003). In contrast, IL-33 (R = -0.01, p = 0.93), IL-1β (R = -0.10, p = 0.20), soluble neprilysin (sNEP; R = 0.09, p = 0.24), tumor necrosis factor-alpha (TNF-α; R = 0.07, p = 0.39), and TNF-α receptor superfamily member 1A (TNFRSF1A; R = 0.14, p = 0.07) did not. Total B-line sum correlated significantly, although moderately, with congestion and several inflammation biomarkers. Unexpectedly, the highest correlation found was with hsTnT. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/237945https://dx.doi.org/urn:doi:10.33393/jcb.2020.2164reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2379452026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Lung ultrasound and biomarkers in primary care Partners for a better management of patients with heart failure? |
| title |
Lung ultrasound and biomarkers in primary care |
| spellingShingle |
Lung ultrasound and biomarkers in primary care Domingo, Mar|||0000-0002-2935-1272 Biomarkers Congestion Diagnosis Heart failure Lung ultrasound Primary care |
| title_short |
Lung ultrasound and biomarkers in primary care |
| title_full |
Lung ultrasound and biomarkers in primary care |
| title_fullStr |
Lung ultrasound and biomarkers in primary care |
| title_full_unstemmed |
Lung ultrasound and biomarkers in primary care |
| title_sort |
Lung ultrasound and biomarkers in primary care |
| dc.creator.none.fl_str_mv |
Domingo, Mar|||0000-0002-2935-1272 Conangla, Laura|||0000-0002-6102-3033 Lupón, Josep|||0000-0002-5601-9611 Wilke, Asunción Juncà Puig, Gladys|||0000-0002-4421-5658 Revuelta-López, Elena|||0000-0001-8962-5936 Tejedor, Xavier Bayés-Genís, Antoni|||0000-0002-3044-197X |
| author |
Domingo, Mar|||0000-0002-2935-1272 |
| author_facet |
Domingo, Mar|||0000-0002-2935-1272 Conangla, Laura|||0000-0002-6102-3033 Lupón, Josep|||0000-0002-5601-9611 Wilke, Asunción Juncà Puig, Gladys|||0000-0002-4421-5658 Revuelta-López, Elena|||0000-0001-8962-5936 Tejedor, Xavier Bayés-Genís, Antoni|||0000-0002-3044-197X |
| author_role |
author |
| author2 |
Conangla, Laura|||0000-0002-6102-3033 Lupón, Josep|||0000-0002-5601-9611 Wilke, Asunción Juncà Puig, Gladys|||0000-0002-4421-5658 Revuelta-López, Elena|||0000-0001-8962-5936 Tejedor, Xavier Bayés-Genís, Antoni|||0000-0002-3044-197X |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Biomarkers Congestion Diagnosis Heart failure Lung ultrasound Primary care |
| topic |
Biomarkers Congestion Diagnosis Heart failure Lung ultrasound Primary care |
| description |
The association of pulmonary congestion assessed by lung ultrasound (LUS) and biomarkers-other than N-terminal pro-brain natriuretic peptide (NT-proBNP)-is uncertain. We investigated the relationship between total B-line count by LUS and several biomarkers in outpatients with suspicion of heart failure (HF). Primary care patients with suspected new-onset nonacute HF were evaluated both with a 12-scan LUS protocol (8 anterolateral areas plus 4 lower posterior thoracic areas) and 11 inflammatory and cardiovascular biomarkers. A cardiologist blinded to LUS and biomarkers except NT-proBNP confirmed HF diagnosis. After log-transformation of biomarkers' concentrations, unadjusted and adjusted correlations were performed. A total of 170 patients were included (age 76 ± 10 years, 67.6% women). HF diagnosis was confirmed in 38 (22.4%) patients. After adjustment by age, sex, body mass index, and renal function, total B-line sum significantly correlated with NT-proBNP (R = 0.29, p < 0.001), growth/differentiation factor-15 (GDF-15; R = 0.23, p = 0.003), high-sensitive Troponin T (hsTnT; R = 0.36, p < 0.001), soluble interleukin-1 receptor-like 1 (sST2; R = 0.29, p < 0.001), cancer antigen 125 (CA-125; R = 0.17, p = 0.03), high-sensitivity C-reactive protein (hsCRP; R = 0.20, p = 0.009), and interleukin (IL)-6 (R = 0.23, p = 0.003). In contrast, IL-33 (R = -0.01, p = 0.93), IL-1β (R = -0.10, p = 0.20), soluble neprilysin (sNEP; R = 0.09, p = 0.24), tumor necrosis factor-alpha (TNF-α; R = 0.07, p = 0.39), and TNF-α receptor superfamily member 1A (TNFRSF1A; R = 0.14, p = 0.07) did not. Total B-line sum correlated significantly, although moderately, with congestion and several inflammation biomarkers. Unexpectedly, the highest correlation found was with hsTnT. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/237945 https://dx.doi.org/urn:doi:10.33393/jcb.2020.2164 |
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https://ddd.uab.cat/record/237945 https://dx.doi.org/urn:doi:10.33393/jcb.2020.2164 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
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eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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