Contact lenses as drug-delivery systems: a promising therapeutic tool

The ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical te...

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Autores: Holgado Villafuerte, María Ángeles, Anguiano Domínguez, A., Martín Banderas, Lucía
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/96759
Acceso en línea:https://hdl.handle.net/11441/96759
https://doi.org/10.1016/j.oftal.2019.07.009
Access Level:acceso abierto
Palabra clave:Contact lenses
Controlled release
Eye diseases
Ocular bioavailability
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spelling Contact lenses as drug-delivery systems: a promising therapeutic toolLentes de contacto para vehiculizar principios activos: una prometedora herramienta terapéuticaHolgado Villafuerte, María ÁngelesAnguiano Domínguez, A.Martín Banderas, LucíaContact lensesControlled releaseEye diseasesOcular bioavailabilityThe ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical technology, attempts have been made to use various solutions in order to increase bioavailability in the most common pharmaceutical forms, it has not been entirely satisfactory. In this context, contact lenses are presented as drug delivery systems that largely remedy these two major problems and offer other additional advantages. Therefore, the use of contact lenses as drug carrying systems has been increasingly investigated in recent years, as they can increase the bioavailability of these drugs, leading to an increase in therapeutic efficacy and compliance. The main techniques used to achieve this goal are included in this review, including immersion in drug solutions, use of vitamin E barriers, molecular printing, colloidal systems, etc. The most interesting results, depending on the different eye pathologies, are presented. Although the use of contact lenses as a vehicle for the release of active ingredients is a relatively novel strategy, there are already many studies and trials that support it. In any case, further research needs to be carried out to finally reach an effective, safe, and stable product that can be marketed.nLa administración ocular de fármacos utilizando formas farmacéuticas tradicionales, comolas gotas oftálmicas o pomadas entre otras, proporciona una baja biodisponibilidad delos fármacos así como múltiples administraciones al día con el consiguiente peligro deincumplimiento terapéutico. Aunque la Tecnología Farmacéutica ha intentado proponer diversas soluciones para aumentar la biodisponibilidad en las formas farmacéuticas más comunes, no ha sido del todo satisfactorio. En este contexto, las lentes de contacto se pre- sentan como sistemas de liberación de fármacos que subsanan en gran medida estos dos grandes problemas y ofrecen otras ventajas adicionales. Por ello, en los últimos an˜ os, se ha investigado con más empen˜ o el uso de lentes de contacto como sistemas portadores de fármacos, ya que pueden aumentar la biodisponibilidad de los mismos, proporcionando un aumento de la eficacia y cumplimiento terapéuticos. En la presente revisión se han referenciado las principales técnicas utilizadas para alcanzar dicho fin: inmersión en soluciones de fármaco, uso de barreras de vitamina E, impresión molecular, sistemas coloidales, etc. A continuación se recogen los resultados más intere- santes encontrados en función de las distintas patologías oculares. El uso de lentes de contacto para la vehiculización y liberación de principios activos es una estrategia relativamente novedosa aunque ya tiene muchos estudios y ensayos que lo sustentan. De todas formas se deben seguir investigando para alcanzar finalmente un producto eficaz, seguro y estable, y que pueda llegar a ser comercializado.ElsevierFarmacia y Tecnología Farmacéutica2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/96759https://doi.org/10.1016/j.oftal.2019.07.009reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésArchivos de la Sociedad Espanola de Oftalmologia, 95 (1), 24-33.http://dx.doi.org/10.1016/j.oftal.2019.07.009info:eu-repo/semantics/openAccessoai:idus.us.es:11441/967592026-06-17T12:51:07Z
dc.title.none.fl_str_mv Contact lenses as drug-delivery systems: a promising therapeutic tool
Lentes de contacto para vehiculizar principios activos: una prometedora herramienta terapéutica
title Contact lenses as drug-delivery systems: a promising therapeutic tool
spellingShingle Contact lenses as drug-delivery systems: a promising therapeutic tool
Holgado Villafuerte, María Ángeles
Contact lenses
Controlled release
Eye diseases
Ocular bioavailability
title_short Contact lenses as drug-delivery systems: a promising therapeutic tool
title_full Contact lenses as drug-delivery systems: a promising therapeutic tool
title_fullStr Contact lenses as drug-delivery systems: a promising therapeutic tool
title_full_unstemmed Contact lenses as drug-delivery systems: a promising therapeutic tool
title_sort Contact lenses as drug-delivery systems: a promising therapeutic tool
dc.creator.none.fl_str_mv Holgado Villafuerte, María Ángeles
Anguiano Domínguez, A.
Martín Banderas, Lucía
author Holgado Villafuerte, María Ángeles
author_facet Holgado Villafuerte, María Ángeles
Anguiano Domínguez, A.
Martín Banderas, Lucía
author_role author
author2 Anguiano Domínguez, A.
Martín Banderas, Lucía
author2_role author
author
dc.contributor.none.fl_str_mv Farmacia y Tecnología Farmacéutica
dc.subject.none.fl_str_mv Contact lenses
Controlled release
Eye diseases
Ocular bioavailability
topic Contact lenses
Controlled release
Eye diseases
Ocular bioavailability
description The ocular administration of drugs using traditional pharmaceutical forms, including eye drops or ointments, results in low bioavailability, as well as requiring multiple administrations per day, with the consequent danger of therapeutic non-compliance. Although, through the use of pharmaceutical technology, attempts have been made to use various solutions in order to increase bioavailability in the most common pharmaceutical forms, it has not been entirely satisfactory. In this context, contact lenses are presented as drug delivery systems that largely remedy these two major problems and offer other additional advantages. Therefore, the use of contact lenses as drug carrying systems has been increasingly investigated in recent years, as they can increase the bioavailability of these drugs, leading to an increase in therapeutic efficacy and compliance. The main techniques used to achieve this goal are included in this review, including immersion in drug solutions, use of vitamin E barriers, molecular printing, colloidal systems, etc. The most interesting results, depending on the different eye pathologies, are presented. Although the use of contact lenses as a vehicle for the release of active ingredients is a relatively novel strategy, there are already many studies and trials that support it. In any case, further research needs to be carried out to finally reach an effective, safe, and stable product that can be marketed.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/96759
https://doi.org/10.1016/j.oftal.2019.07.009
url https://hdl.handle.net/11441/96759
https://doi.org/10.1016/j.oftal.2019.07.009
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Archivos de la Sociedad Espanola de Oftalmologia, 95 (1), 24-33.
http://dx.doi.org/10.1016/j.oftal.2019.07.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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