Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)

Background: Anopheles arabiensis is an opportunistic malaria vector that rests and feeds outdoors, circumventingcurrent indoor vector control methods. Furthermore, this vector will readily feed on both animals and humans. Target‑ing this vector while feeding on animals can provide an additional inte...

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Detalhes bibliográficos
Autores: Fuente García, José de Jesús de la, Letinic, Blazenka Danica, Contreras Rojo, Marinela, Leah Dahan, Yael, Linnekugel, Ingrid, Koekemoer, Lizette
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/148
Acesso em linha:https://doi.org/10.1186/s13071-021-04711-8
http://hdl.handle.net/10578/148
Access Level:acceso abierto
Palavra-chave:Malaria
Inmunización
Vacunas
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spelling Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)Fuente García, José de Jesús de laLetinic, Blazenka DanicaContreras Rojo, MarinelaLeah Dahan, YaelLinnekugel, IngridKoekemoer, LizetteMalariaInmunizaciónVacunasBackground: Anopheles arabiensis is an opportunistic malaria vector that rests and feeds outdoors, circumventingcurrent indoor vector control methods. Furthermore, this vector will readily feed on both animals and humans. Target‑ing this vector while feeding on animals can provide an additional intervention for the current vector control activi‑ties. Previous results have displayed the efficacy of using Subolesin/Akirin ortholog vaccines for the control of multipleectoparasite infestations. This made Akirin a potential antigen for vaccine development against An. arabiensis.Methods: The efficacy of three antigens, namely recombinant Akirin from An. arabiensis, recombinant Akirin fromAedes albopictus, and recombinant Q38 (Akirin/Subolesin chimera) were evaluated as novel interventions for An.arabiensis vector control. Immunisation trials were conducted based on the concept that mosquitoes feeding onvaccinated balb/c mice would ingest antibodies specific to the target antigen. The antibodies would interact with thetarget antigen in the arthropod vector, subsequently disrupting its function.Results: All three antigens successfully reduced An. arabiensis survival and reproductive capacities, with a vaccineefficacy of 68–73%.Conclusions: These results were the first to show that hosts vaccinated with recombinant Akirin vaccines coulddevelop a protective response against this outdoor malaria transmission vector, thus providing a step towards thedevelopment of a novel intervention for An. arabiensis vector control.Springer202220222021info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.1186/s13071-021-04711-8http://hdl.handle.net/10578/148reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/1482026-05-27T07:36:41Z
dc.title.none.fl_str_mv Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
title Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
spellingShingle Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
Fuente García, José de Jesús de la
Malaria
Inmunización
Vacunas
title_short Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
title_full Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
title_fullStr Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
title_full_unstemmed Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
title_sort Additional evidence on the efficacy of different Akirin vaccines assessed on Anopheles arabiensis (Diptera: Culicidae)
dc.creator.none.fl_str_mv Fuente García, José de Jesús de la
Letinic, Blazenka Danica
Contreras Rojo, Marinela
Leah Dahan, Yael
Linnekugel, Ingrid
Koekemoer, Lizette
author Fuente García, José de Jesús de la
author_facet Fuente García, José de Jesús de la
Letinic, Blazenka Danica
Contreras Rojo, Marinela
Leah Dahan, Yael
Linnekugel, Ingrid
Koekemoer, Lizette
author_role author
author2 Letinic, Blazenka Danica
Contreras Rojo, Marinela
Leah Dahan, Yael
Linnekugel, Ingrid
Koekemoer, Lizette
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malaria
Inmunización
Vacunas
topic Malaria
Inmunización
Vacunas
description Background: Anopheles arabiensis is an opportunistic malaria vector that rests and feeds outdoors, circumventingcurrent indoor vector control methods. Furthermore, this vector will readily feed on both animals and humans. Target‑ing this vector while feeding on animals can provide an additional intervention for the current vector control activi‑ties. Previous results have displayed the efficacy of using Subolesin/Akirin ortholog vaccines for the control of multipleectoparasite infestations. This made Akirin a potential antigen for vaccine development against An. arabiensis.Methods: The efficacy of three antigens, namely recombinant Akirin from An. arabiensis, recombinant Akirin fromAedes albopictus, and recombinant Q38 (Akirin/Subolesin chimera) were evaluated as novel interventions for An.arabiensis vector control. Immunisation trials were conducted based on the concept that mosquitoes feeding onvaccinated balb/c mice would ingest antibodies specific to the target antigen. The antibodies would interact with thetarget antigen in the arthropod vector, subsequently disrupting its function.Results: All three antigens successfully reduced An. arabiensis survival and reproductive capacities, with a vaccineefficacy of 68–73%.Conclusions: These results were the first to show that hosts vaccinated with recombinant Akirin vaccines coulddevelop a protective response against this outdoor malaria transmission vector, thus providing a step towards thedevelopment of a novel intervention for An. arabiensis vector control.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s13071-021-04711-8
http://hdl.handle.net/10578/148
url https://doi.org/10.1186/s13071-021-04711-8
http://hdl.handle.net/10578/148
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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