Effect of antihistamine up-dosing in chronic urticaria

Chronic urticaria has an important impact upon patient quality of life, and no treatment has yet been developed capable of effectively controlling the disease. The most recent guidelines recommend the use of non-sedating antihistamines at high doses as second-step therapy before resorting to other t...

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Detalles Bibliográficos
Autores: Ferrer-Puga, M. (Marta)|||/items/ab9d3fc5-5095-4f28-8018-f157d8c9fce0, Sastre, J. (Joaquín)|||/items/0ca81e29-a084-4fc1-b5d1-ac10b724ec18, Jauregui, I. (I.)|||/items/731ed539-2c09-40e6-a268-2c92953e0455, Davila, I. (I.)|||/items/714dba7a-d8fa-4733-8400-a09857f7ddf4, Montoro-Lacomba, J. (Javier)|||/items/819abd88-8a9b-4013-b0e6-bb7d3b0e9748, Cuvillo, A. (A.) del|||/items/081a7cb2-2ca3-43ce-8c0a-d102d6470e70, Mullol, J. (J.)|||/items/5f37bc15-5414-4b93-9b41-96068d746685, Bartra, J. (Joan)|||/items/406d5b52-dc6a-4698-bb38-fc67cf00b1c0, Valero-Santiago, A. (Antonio)|||/items/9a2a9f79-7848-4007-82e6-d4d8988e327b
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/22320
Acceso en línea:https://hdl.handle.net/10171/22320
Access Level:acceso abierto
Palabra clave:Chronic urticaria.
Antihistamines
Chronic urticaria treatment.
Descripción
Sumario:Chronic urticaria has an important impact upon patient quality of life, and no treatment has yet been developed capable of effectively controlling the disease. The most recent guidelines recommend the use of non-sedating antihistamines at high doses as second-step therapy before resorting to other treatments. The present review examines the studies published to date on the use of H1 antihistamines at doses higher than those indicated as therapeutic doses in chronic urticaria. Most of the studies report no significant differences among the studied doses – only a tendency towards increased response on elevating the dose.There are no clinically well designed, randomized double-blind trials comparing efficacy between therapeutic doses and doses higher than those indicated in the corresponding Summary of Product Characteristics. Likewise, there are insufficient data to conduct a meta-analysis and thus classify the degree of evidence of the few available studies, which moreover present contradictory results. At present, the prescription of high-dose H1 antihistamines is based only on experts opinion. However, considering the high safety profile of these drugs, it would be a good option to evaluate their efficacy at high doses, before moving on to other therapeutic steps.

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