D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats.

To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver an...

Descripción completa

Detalles Bibliográficos
Autores: Navarro, Juan A, Decara, Juan, Medina-Vera, Dina, Tovar, Rubén, Suarez, Juan|Pavón, Francisco-Javier, Serrano, Antonia, Vida, Margarita, Gutierrez-Adan, Alfonso, Sanjuan, Carlos, Baixeras, Elena, Fonseca, Fernando Rodríguez de
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18074
Acceso en línea:http://hdl.handle.net/20.500.12105/18074
Access Level:acceso abierto
Palabra clave:AKT
D-Pinitol
Ghrelin
Insulin
Insulin resistance
Liver
Phosphorylation
Administration, Oral
Animals
Depression, Chemical
Fabaceae
Glucagon
Glycogen
Glycogen Synthase Kinase 3
Glycolysis
Inositol
Insulin Secretion
Male
Proto-Oncogene Proteins c-akt
Pyruvate Kinase
Rats, Wistar
Descripción
Sumario:To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.

Similares en LA Referencia