3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine

Producción Científica

Detalhes bibliográficos
Autores: Vila, Mercedes, García, Ana, Girotti ., Alessandra, Alonso Rodrigo, Matilde, Rodríguez Cabello, José Carlos, González Vázquez, Arlyng, Planell i Estany, Josep A., Engel López, Elisabeth, Buján Varela, Julia, García Honduvilla, Natalio, Vallet Regí, María
Formato: artículo
Fecha de publicación:2016
País:España
Recursos:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/21699
Acesso em linha:https://doi.org/10.1016/j.actbio.2016.09.016
http://uvadoc.uva.es/handle/10324/21699
Access Level:acceso abierto
Palavra-chave:Biomateriales - Aplicaciones médicas
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spelling 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicineVila, MercedesGarcía, AnaGirotti ., AlessandraAlonso Rodrigo, MatildeRodríguez Cabello, José CarlosGonzález Vázquez, ArlyngPlanell i Estany, Josep A.Engel López, ElisabethBuján Varela, JuliaGarcía Honduvilla, NatalioVallet Regí, MaríaBiomateriales - Aplicaciones médicasProducción CientíficaThe current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) func- tionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineer- ing: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxya- patite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts.Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)Ministerio de Ciencia e Innovación (proyectos MAT2012-35556 y MAT2009-14195-C03-02)Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14)Elsevier2016info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1016/j.actbio.2016.09.016http://uvadoc.uva.es/handle/10324/21699reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttp://www.sciencedirect.cominfo:eu-repo/grantAgreement/EC/H2020/642687info:eu-repo/grantAgreement/EC/H2020/646075info:eu-repo/grantAgreement/EC/FP7/278557info:eu-repo/grantAgreement/EC/FP7/317306info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/216992026-06-13T12:44:47Z
dc.title.none.fl_str_mv 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
title 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
spellingShingle 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
Vila, Mercedes
Biomateriales - Aplicaciones médicas
title_short 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
title_full 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
title_fullStr 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
title_full_unstemmed 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
title_sort 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine
dc.creator.none.fl_str_mv Vila, Mercedes
García, Ana
Girotti ., Alessandra
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
González Vázquez, Arlyng
Planell i Estany, Josep A.
Engel López, Elisabeth
Buján Varela, Julia
García Honduvilla, Natalio
Vallet Regí, María
author Vila, Mercedes
author_facet Vila, Mercedes
García, Ana
Girotti ., Alessandra
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
González Vázquez, Arlyng
Planell i Estany, Josep A.
Engel López, Elisabeth
Buján Varela, Julia
García Honduvilla, Natalio
Vallet Regí, María
author_role author
author2 García, Ana
Girotti ., Alessandra
Alonso Rodrigo, Matilde
Rodríguez Cabello, José Carlos
González Vázquez, Arlyng
Planell i Estany, Josep A.
Engel López, Elisabeth
Buján Varela, Julia
García Honduvilla, Natalio
Vallet Regí, María
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomateriales - Aplicaciones médicas
topic Biomateriales - Aplicaciones médicas
description Producción Científica
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.actbio.2016.09.016
http://uvadoc.uva.es/handle/10324/21699
url https://doi.org/10.1016/j.actbio.2016.09.016
http://uvadoc.uva.es/handle/10324/21699
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://www.sciencedirect.com
info:eu-repo/grantAgreement/EC/H2020/642687
info:eu-repo/grantAgreement/EC/H2020/646075
info:eu-repo/grantAgreement/EC/FP7/278557
info:eu-repo/grantAgreement/EC/FP7/317306
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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