Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study

Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with...

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Autores: Nunez-Pereira, S, Benavent, E, Ulldemolins, M, Sobrino-Diaz, B, Iribarren, JA, Escudero-Sanchez, R, Del Toro, MD, Nodar, A, Sorli, L, Bahamonde, A, Vilchez, HH, Gasch, O, Munez, E, Rodriguez-Montserrat, D, Garcia-Pais, MJ, Haddad, S, Sellares-Nadal, J, Murillo, O, Rodriguez-Pardo, D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3289
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/3289
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151745862&doi=10.3390%2fantibiotics12030518&partnerID=40&md5=38b3d630a55be60c9e7c9c5959c47483
Access Level:acceso abierto
Palabra clave:surgical site infection
spine surgery
Cutibacterium spp
rifampin
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spelling Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional StudyNunez-Pereira, SBenavent, EUlldemolins, MSobrino-Diaz, BIribarren, JAEscudero-Sanchez, RDel Toro, MDNodar, ASorli, LBahamonde, AVilchez, HHGasch, OMunez, ERodriguez-Montserrat, DGarcia-Pais, MJHaddad, SSellares-Nadal, JMurillo, ORodriguez-Pardo, Dsurgical site infectionspine surgeryCutibacterium spprifampinInfection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/3289https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151745862&doi=10.3390%2fantibiotics12030518&partnerID=40&md5=38b3d630a55be60c9e7c9c5959c47483Antibiotics-BaselISSN: 20796382reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p32892026-06-21T15:30:37Z
dc.title.none.fl_str_mv Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
spellingShingle Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
Nunez-Pereira, S
surgical site infection
spine surgery
Cutibacterium spp
rifampin
title_short Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_full Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_fullStr Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_full_unstemmed Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_sort Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
dc.creator.none.fl_str_mv Nunez-Pereira, S
Benavent, E
Ulldemolins, M
Sobrino-Diaz, B
Iribarren, JA
Escudero-Sanchez, R
Del Toro, MD
Nodar, A
Sorli, L
Bahamonde, A
Vilchez, HH
Gasch, O
Munez, E
Rodriguez-Montserrat, D
Garcia-Pais, MJ
Haddad, S
Sellares-Nadal, J
Murillo, O
Rodriguez-Pardo, D
author Nunez-Pereira, S
author_facet Nunez-Pereira, S
Benavent, E
Ulldemolins, M
Sobrino-Diaz, B
Iribarren, JA
Escudero-Sanchez, R
Del Toro, MD
Nodar, A
Sorli, L
Bahamonde, A
Vilchez, HH
Gasch, O
Munez, E
Rodriguez-Montserrat, D
Garcia-Pais, MJ
Haddad, S
Sellares-Nadal, J
Murillo, O
Rodriguez-Pardo, D
author_role author
author2 Benavent, E
Ulldemolins, M
Sobrino-Diaz, B
Iribarren, JA
Escudero-Sanchez, R
Del Toro, MD
Nodar, A
Sorli, L
Bahamonde, A
Vilchez, HH
Gasch, O
Munez, E
Rodriguez-Montserrat, D
Garcia-Pais, MJ
Haddad, S
Sellares-Nadal, J
Murillo, O
Rodriguez-Pardo, D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv surgical site infection
spine surgery
Cutibacterium spp
rifampin
topic surgical site infection
spine surgery
Cutibacterium spp
rifampin
description Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/3289
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151745862&doi=10.3390%2fantibiotics12030518&partnerID=40&md5=38b3d630a55be60c9e7c9c5959c47483
url https://i3pt.portalinvestigacion.com/publicaciones/3289
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85151745862&doi=10.3390%2fantibiotics12030518&partnerID=40&md5=38b3d630a55be60c9e7c9c5959c47483
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Antibiotics-Basel
ISSN: 20796382
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
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