Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study
Inner nuclear layer; Multiple sclerosis; Optical coherence tomography
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/5056 |
| Acceso en línea: | https://hdl.handle.net/11351/5056 |
| Access Level: | acceso abierto |
| Palabra clave: | Esclerosi múltiple Ulls - Tomografia Retina DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence ANATOMY::Sense Organs::Eye::Retina ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica ANATOMÍA::órganos de los sentidos::ojo::retina |
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| dc.title.none.fl_str_mv |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| title |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| spellingShingle |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study Balk, Lisanne J Esclerosi múltiple Ulls - Tomografia Retina DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence ANATOMY::Sense Organs::Eye::Retina ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica ANATOMÍA::órganos de los sentidos::ojo::retina |
| title_short |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| title_full |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| title_fullStr |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| title_full_unstemmed |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| title_sort |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT study |
| dc.creator.none.fl_str_mv |
Balk, Lisanne J Coric, Danko Knier, Benjamin Zimmermann, Hanna G Behbehani, Raed Alroughani, Raed Vidal Jordana, Angela Montalban Gairín, Xavier |
| author |
Balk, Lisanne J |
| author_facet |
Balk, Lisanne J Coric, Danko Knier, Benjamin Zimmermann, Hanna G Behbehani, Raed Alroughani, Raed Vidal Jordana, Angela Montalban Gairín, Xavier |
| author_role |
author |
| author2 |
Coric, Danko Knier, Benjamin Zimmermann, Hanna G Behbehani, Raed Alroughani, Raed Vidal Jordana, Angela Montalban Gairín, Xavier |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
[Balk LJ, Coric D] Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. [Knier B] Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany. [Zimmermann HG] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. [Behbehani R] Al-Bahar Ophthalmology Centre, Ibn Sina Hospital, Kuwait. [Alroughani R] Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait. [Vidal-Jordana A] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Canada Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Esclerosi múltiple Ulls - Tomografia Retina DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence ANATOMY::Sense Organs::Eye::Retina ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica ANATOMÍA::órganos de los sentidos::ojo::retina |
| topic |
Esclerosi múltiple Ulls - Tomografia Retina DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence ANATOMY::Sense Organs::Eye::Retina ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica ANATOMÍA::órganos de los sentidos::ojo::retina |
| description |
Inner nuclear layer; Multiple sclerosis; Optical coherence tomography |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/5056 |
| url |
https://hdl.handle.net/11351/5056 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Multiple Sclerosis Journal - Experimental, Translational and Clinical;5(3) https://journals.sagepub.com/doi/10.1177/2055217319871582 |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
SAGE Publications |
| publisher.none.fl_str_mv |
SAGE Publications |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
| reponame_str |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| collection |
Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869403306516807680 |
| spelling |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis: a longitudinal OCT studyBalk, Lisanne JCoric, DankoKnier, BenjaminZimmermann, Hanna GBehbehani, RaedAlroughani, RaedVidal Jordana, AngelaMontalban Gairín, XavierEsclerosi múltipleUlls - TomografiaRetinaDISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple SclerosisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical CoherenceANATOMY::Sense Organs::Eye::RetinaENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso::enfermedades desmielinizantes::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltipleTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia ópticaANATOMÍA::órganos de los sentidos::ojo::retinaInner nuclear layer; Multiple sclerosis; Optical coherence tomographyCapa nuclear interna; Esclerosis múltiple; Tomografía de coherencia ópticaCapa nuclear interior; Esclerosi múltiple; Tomografia de coherència òpticaBackground: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS. Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68.3% female) and 92 healthy controls (63.4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre. Results: There was a significant increase in INL volume in eyes with new MSON during the study (N=61/1562, β=0.01mm3, p<.001). Clinical relapses (other than MSON) were significantly associated with increased INL volume (β=0.005, p=.025). INL volume was independent of disease progression (β=0.002mm3, p=.474). Conclusion: Our data demonstrate that an increase in INL volume is associated with MSON and the occurrence of clinical relapses. Therefore, INL volume changes may be useful as an outcome marker for inflammatory disease activity in MSON and MS treatment trials.SAGE Publications[Balk LJ, Coric D] Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. [Knier B] Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany. [Zimmermann HG] Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, Germany. [Behbehani R] Al-Bahar Ophthalmology Centre, Ibn Sina Hospital, Kuwait. [Alroughani R] Division of Neurology, Department of Medicine, Amiri Hospital, Kuwait. [Vidal-Jordana A] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Montalban X] Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Servei de Neuroimmunologia Clínica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, CanadaVall d'Hebron Barcelona Hospital Campus202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/5056Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésMultiple Sclerosis Journal - Experimental, Translational and Clinical;5(3)https://journals.sagepub.com/doi/10.1177/2055217319871582Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/50562026-06-12T09:38:37Z |
| score |
15.812429 |