The Behavioral and Psychological Symptoms of Dementia in down Syndrome Scale (BPSD-DS II)

Background: People with Down syndrome (DS) are at high risk to develop Alzheimer's disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are l...

Descripción completa

Detalles Bibliográficos
Autores: Dekker, Alain D.|||0000-0001-8771-218X, Ulgiati, Aurora M.|||0000-0001-6393-946X, Groen, Henk|||0000-0002-6629-318X, Boxelaar, Vicent A., Sacco, Silvia, Falquero, Ségolène, Carfi, Angelo|||0000-0002-9837-7003, Di Paola, Antonella, Benejam, Bessy|||0000-0002-6789-8615, Valldeneu, Silvia|||0000-0003-3497-886X, Fopma, Roelie, Oosterik, Marjo, Hermelink, Marloes, Beugelsdijk, Gonny, Schippers, Mieke, Henstra, Hepie, Scholten-Kuiper, Martine, Willink-Vos, Judith, De Ruiter, Lisa, Willems, Liesbeth, Loonstra-De Jong, Anneke, Coppus, Antonia, Tollenaere, Marleen, Fortea, Juan|||0000-0002-1340-638X, Onder, Graziano, Rebillat, Anne-Sophie|||0000-0003-1995-9177, Van Dam, Debby, De Deyn, Peter Paul|||0000-0002-2228-2964
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:272161
Acceso en línea:https://ddd.uab.cat/record/272161
https://dx.doi.org/urn:doi:10.3233/JAD-201427
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Behavior
Behavioral and psychological symptoms of dementia
Dementia
Down syndrome
Intellectual disabilities
Neuropsychiatric symptoms
Trisomy 21
Descripción
Sumario:Background: People with Down syndrome (DS) are at high risk to develop Alzheimer's disease dementia (AD). Behavioral and psychological symptoms of dementia (BPSD) are common and may also serve as early signals for dementia. However, comprehensive evaluation scales for BPSD, adapted to DS, are lacking. Therefore, we previously developed the BPSD-DS scale to identify behavioral changes between the last six months and pre-existing life-long characteristic behavior. Objective: To optimize and further study the scale (discriminative ability and reliability) in a large representative DS study population. Methods: Optimization was based on item irrelevance and clinical experiences obtained in the initial study. Using the shortened and refined BPSD-DS II, informant interviews were conducted to evaluate 524 individuals with DS grouped according to dementia status: no dementia (DS, N = 292), questionable dementia (DS + Q, N = 119), and clinically diagnosed dementia (DS + AD, N = 113). Results: Comparing item change scores between groups revealed prominent changes in frequency and severity for anxious, sleep-related, irritable, restless/stereotypic, apathetic, depressive, and eating/drinking behavior. For most items, the proportion of individuals displaying an increased frequency was highest in DS + AD, intermediate in DS + Q, and lowest in DS. For various items within sections about anxious, sleep-related, irritable, apathetic, and depressive behaviors, the proportion of individuals showing an increased frequency was already substantial in DS + Q, suggesting that these changes may serve as early signals of AD in DS. Reliability data were promising. Conclusion: The optimized scale yields largely similar results as obtained with the initial version. Systematically evaluating BPSD in DS may increase understanding of changes among caregivers and (timely) adaptation of care/treatment.

Similares en LA Referencia