Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we repor...

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Autores: Ramos-Vicente, D, Ji, J, Gratacos-Batlle, E, Gou, G, Reig-Viader, R, Luis, J, Burguera, D, Navas-Perez, E, Garcia-Fernandez, J, Fuentes-Prior, P, Escriva, H, Roher, N, Soto, D, Bayes, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p3219
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3219
https://ddd.uab.cat/record/253730
Access Level:acceso abierto
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spelling Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific eventsRamos-Vicente, DJi, JGratacos-Batlle, EGou, GReig-Viader, RLuis, JBurguera, DNavas-Perez, EGarcia-Fernandez, JFuentes-Prior, PEscriva, HRoher, NSoto, DBayes, AGlutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.ELIFE SCIENCES PUBLICATIONS LTD2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3219https://ddd.uab.cat/record/253730eLifeISSN: 2050084Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p32192026-06-14T12:41:47Z
dc.title.none.fl_str_mv Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
title Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
spellingShingle Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
Ramos-Vicente, D
title_short Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
title_full Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
title_fullStr Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
title_full_unstemmed Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
title_sort Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
dc.creator.none.fl_str_mv Ramos-Vicente, D
Ji, J
Gratacos-Batlle, E
Gou, G
Reig-Viader, R
Luis, J
Burguera, D
Navas-Perez, E
Garcia-Fernandez, J
Fuentes-Prior, P
Escriva, H
Roher, N
Soto, D
Bayes, A
author Ramos-Vicente, D
author_facet Ramos-Vicente, D
Ji, J
Gratacos-Batlle, E
Gou, G
Reig-Viader, R
Luis, J
Burguera, D
Navas-Perez, E
Garcia-Fernandez, J
Fuentes-Prior, P
Escriva, H
Roher, N
Soto, D
Bayes, A
author_role author
author2 Ji, J
Gratacos-Batlle, E
Gou, G
Reig-Viader, R
Luis, J
Burguera, D
Navas-Perez, E
Garcia-Fernandez, J
Fuentes-Prior, P
Escriva, H
Roher, N
Soto, D
Bayes, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
description Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3219
https://ddd.uab.cat/record/253730
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3219
https://ddd.uab.cat/record/253730
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELIFE SCIENCES PUBLICATIONS LTD
publisher.none.fl_str_mv ELIFE SCIENCES PUBLICATIONS LTD
dc.source.none.fl_str_mv eLife
ISSN: 2050084X
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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