Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. New non-invasive diagnostic tools are needed to promptly treat this disease and avoid its complications. This study aimed to find key metabolites and related variables that could be used to pre...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/117295 |
| Acesso em linha: | https://hdl.handle.net/10171/117295 |
| Access Level: | acceso abierto |
| Palavra-chave: | Insulin resistance Isoliquiritigenin Metabolomics Nonalcoholic fatty liver disease Visceral adipose tissue |
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Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver diseaseMogna-Peláez, P. (Paola)|||/items/5be56ba2-bd55-4ea5-af40-e26118b537d8Romo‐Hualde, A. (Ana)|||/items/5c6999e7-dcc3-486f-a0e9-aa5bb6d96f4fRiezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebMuñoz-Prieto, D. (David)|||/items/c0b800f6-8ccc-4508-b8ea-6189cc7d8a99Herrero-Santos, J.I. (José Ignacio)|||/items/4df6083a-1ce6-4c19-a3fa-1b7d8bc58e1dElorz-Carlón, M. (Mariana)|||/items/2bb34072-5d36-4e93-baa5-317e6f1e8247Benito-Boíllos, A. (Alberto)|||/items/36f5562b-2392-4f6a-a747-a57b8b201069Monreal, J.I. (José Ignacio)|||/items/54707c2a-e68a-4e73-9141-0276a5bc7a2bTur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019eMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fbZulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239Insulin resistanceIsoliquiritigeninMetabolomicsNonalcoholic fatty liver diseaseVisceral adipose tissueNonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. New non-invasive diagnostic tools are needed to promptly treat this disease and avoid its complications. This study aimed to find key metabolites and related variables that could be used to predict and diagnose NAFLD. Ninety-eight subjects with NAFLD and 45 controls from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. NAFLD was diagnosed and graded by ultrasound and classified into two groups: 0 (controls) and ≥ 1 (NAFLD). Hepatic status was additionally assessed through magnetic resonance imaging (MRI), elastography, and determination of transaminases. Anthropometry, body composition (DXA), biochemical parameters, and lifestyle factors were evaluated as well. Non-targeted metabolomics of serum was performed with high-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-TOF-MS). Isoliquiritigenin (ISO) had the strongest association with NAFLD out of the determinant metabolites. Individuals with higher concentrations of ISO had healthier metabolic and hepatic status and were less likely to have NAFLD (OR 0.13). Receiver operating characteristic (ROC) curves demonstrated the predictive power of ISO in panel combination with other NAFLD and IR-related variables, such as visceral adipose tissue (VAT) (AUROC 0.972), adiponectin (AUROC 0.917), plasmatic glucose (AUROC 0.817), and CK18-M30 (AUROC 0.810). Individuals with lower levels of ISO have from 71 to 82% more risk of presenting NAFLD compared to individuals with higher levels. Metabolites such as ISO, in combination with visceral adipose tissue, IR, and related markers, constitute a potential non-invasive tool to predict and diagnose NAFLD.Springer NatureDadun. Depósito Académico Digital Universidad de Navarra20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/117295reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1172952026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| title |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| spellingShingle |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease Mogna-Peláez, P. (Paola)|||/items/5be56ba2-bd55-4ea5-af40-e26118b537d8 Insulin resistance Isoliquiritigenin Metabolomics Nonalcoholic fatty liver disease Visceral adipose tissue |
| title_short |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| title_full |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| title_fullStr |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| title_full_unstemmed |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| title_sort |
Isoliquiritigenin in combination with visceral adipose tissue and related markers as a predictive tool for nonalcoholic fatty liver disease |
| dc.creator.none.fl_str_mv |
Mogna-Peláez, P. (Paola)|||/items/5be56ba2-bd55-4ea5-af40-e26118b537d8 Romo‐Hualde, A. (Ana)|||/items/5c6999e7-dcc3-486f-a0e9-aa5bb6d96f4f Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Muñoz-Prieto, D. (David)|||/items/c0b800f6-8ccc-4508-b8ea-6189cc7d8a99 Herrero-Santos, J.I. (José Ignacio)|||/items/4df6083a-1ce6-4c19-a3fa-1b7d8bc58e1d Elorz-Carlón, M. (Mariana)|||/items/2bb34072-5d36-4e93-baa5-317e6f1e8247 Benito-Boíllos, A. (Alberto)|||/items/36f5562b-2392-4f6a-a747-a57b8b201069 Monreal, J.I. (José Ignacio)|||/items/54707c2a-e68a-4e73-9141-0276a5bc7a2b Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 |
| author |
Mogna-Peláez, P. (Paola)|||/items/5be56ba2-bd55-4ea5-af40-e26118b537d8 |
| author_facet |
Mogna-Peláez, P. (Paola)|||/items/5be56ba2-bd55-4ea5-af40-e26118b537d8 Romo‐Hualde, A. (Ana)|||/items/5c6999e7-dcc3-486f-a0e9-aa5bb6d96f4f Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Muñoz-Prieto, D. (David)|||/items/c0b800f6-8ccc-4508-b8ea-6189cc7d8a99 Herrero-Santos, J.I. (José Ignacio)|||/items/4df6083a-1ce6-4c19-a3fa-1b7d8bc58e1d Elorz-Carlón, M. (Mariana)|||/items/2bb34072-5d36-4e93-baa5-317e6f1e8247 Benito-Boíllos, A. (Alberto)|||/items/36f5562b-2392-4f6a-a747-a57b8b201069 Monreal, J.I. (José Ignacio)|||/items/54707c2a-e68a-4e73-9141-0276a5bc7a2b Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 |
| author_role |
author |
| author2 |
Romo‐Hualde, A. (Ana)|||/items/5c6999e7-dcc3-486f-a0e9-aa5bb6d96f4f Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6 Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb Muñoz-Prieto, D. (David)|||/items/c0b800f6-8ccc-4508-b8ea-6189cc7d8a99 Herrero-Santos, J.I. (José Ignacio)|||/items/4df6083a-1ce6-4c19-a3fa-1b7d8bc58e1d Elorz-Carlón, M. (Mariana)|||/items/2bb34072-5d36-4e93-baa5-317e6f1e8247 Benito-Boíllos, A. (Alberto)|||/items/36f5562b-2392-4f6a-a747-a57b8b201069 Monreal, J.I. (José Ignacio)|||/items/54707c2a-e68a-4e73-9141-0276a5bc7a2b Tur, J.A. (Josep A.)|||/items/de6900c2-c677-4762-9a97-8e585d1c019e Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131 Abete, I. (Itziar)|||/items/2a1e4080-f97c-44d3-9098-309677a889fb Zulet, M.A. (María Ángeles)|||/items/0a10c4f7-ed81-4b2e-bffe-fbcb7fccd239 |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Insulin resistance Isoliquiritigenin Metabolomics Nonalcoholic fatty liver disease Visceral adipose tissue |
| topic |
Insulin resistance Isoliquiritigenin Metabolomics Nonalcoholic fatty liver disease Visceral adipose tissue |
| description |
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of chronic liver disease in the world. New non-invasive diagnostic tools are needed to promptly treat this disease and avoid its complications. This study aimed to find key metabolites and related variables that could be used to predict and diagnose NAFLD. Ninety-eight subjects with NAFLD and 45 controls from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. NAFLD was diagnosed and graded by ultrasound and classified into two groups: 0 (controls) and ≥ 1 (NAFLD). Hepatic status was additionally assessed through magnetic resonance imaging (MRI), elastography, and determination of transaminases. Anthropometry, body composition (DXA), biochemical parameters, and lifestyle factors were evaluated as well. Non-targeted metabolomics of serum was performed with high-performance liquid chromatography coupled to time-of-flight mass spectrometry (HPLC-TOF-MS). Isoliquiritigenin (ISO) had the strongest association with NAFLD out of the determinant metabolites. Individuals with higher concentrations of ISO had healthier metabolic and hepatic status and were less likely to have NAFLD (OR 0.13). Receiver operating characteristic (ROC) curves demonstrated the predictive power of ISO in panel combination with other NAFLD and IR-related variables, such as visceral adipose tissue (VAT) (AUROC 0.972), adiponectin (AUROC 0.917), plasmatic glucose (AUROC 0.817), and CK18-M30 (AUROC 0.810). Individuals with lower levels of ISO have from 71 to 82% more risk of presenting NAFLD compared to individuals with higher levels. Metabolites such as ISO, in combination with visceral adipose tissue, IR, and related markers, constitute a potential non-invasive tool to predict and diagnose NAFLD. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/117295 |
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https://hdl.handle.net/10171/117295 |
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Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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