The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences

The gut microbiota of the pig is being increasingly studied due to its implications for host homeostasis and the importance of the pig as a meat source and biomedical model of human diseases. However, most studies comparing the microbiome between different breeds do not consider the influence of mat...

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Detalles Bibliográficos
Autores: De las Heras Molina, Ana, Estellé, Jordi, Vázquez Gómez, Marta, López García, Adrián, Pesantez Pacheco, José Luis, Astiz, Susana, Garcia Contreras, Consolación, Escudero Portugués, Rosa María, Isabel Redondo, Beatriz, Gonzalez Bulnes, Antonio, Óvilo, Cristina
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/114002
Acceso en línea:https://hdl.handle.net/20.500.14352/114002
Access Level:acceso abierto
Palabra clave:579.62
Microbiología (Veterinaria)
3109.05 Microbiología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/114002
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spelling The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influencesDe las Heras Molina, AnaEstellé, JordiVázquez Gómez, MartaLópez García, AdriánPesantez Pacheco, José LuisAstiz, SusanaGarcia Contreras, ConsolaciónEscudero Portugués, Rosa MaríaIsabel Redondo, BeatrizGonzalez Bulnes, AntonioÓvilo, Cristina579.62Microbiología (Veterinaria)3109.05 MicrobiologíaThe gut microbiota of the pig is being increasingly studied due to its implications for host homeostasis and the importance of the pig as a meat source and biomedical model of human diseases. However, most studies comparing the microbiome between different breeds do not consider the influence of maternal environment during the colonization of the microbiota. The aim of the present study was to compare the gut microbiota during postnatal growth between two pig genotypes (purebred Iberian vs. crossbreds Iberian x Large White pigs), gestated in a single maternal environment (pure Iberian mothers) inseminated with heterospermic semen. Postnatally, piglets were maintained in the same environmental conditions, and their microbiota was studied at 60 and 210 days old. Results showed that age had the greatest influence on alpha and beta diversity, and genotype also affected beta diversity at both ages. There were differences in the microbiome profile between genotypes at the ASV and genus levels when jointly analyzing the total number of samples, which may help to explain phenotypical differences. When each time-point was analyzed individually, there were more differences at 210 days-old than 60 days-old. Fecal short-chain fatty acids (SCFA) were also affected by age, but not by genotype. These results may be a basis for further research on host genotype interactions with the gut microbiotaPublic Library of ScienceUniversidad Complutense de Madrid20242024-12-0920242024-12-09journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/114002reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-108695RB-C31 EMPLEO DE ANTIOXIDANTES Y PUFA EN LA DIETA DE CERDAS IBERICAS PARA OPTIMIZAR LA HOMEOSTASIS METABOLICA E INTESTINAL Y LA PRODUCTIVIDAD DE LA DESCENDENCIAopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1140022026-06-02T12:44:21Z
dc.title.none.fl_str_mv The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
title The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
spellingShingle The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
De las Heras Molina, Ana
579.62
Microbiología (Veterinaria)
3109.05 Microbiología
title_short The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
title_full The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
title_fullStr The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
title_full_unstemmed The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
title_sort The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences
dc.creator.none.fl_str_mv De las Heras Molina, Ana
Estellé, Jordi
Vázquez Gómez, Marta
López García, Adrián
Pesantez Pacheco, José Luis
Astiz, Susana
Garcia Contreras, Consolación
Escudero Portugués, Rosa María
Isabel Redondo, Beatriz
Gonzalez Bulnes, Antonio
Óvilo, Cristina
author De las Heras Molina, Ana
author_facet De las Heras Molina, Ana
Estellé, Jordi
Vázquez Gómez, Marta
López García, Adrián
Pesantez Pacheco, José Luis
Astiz, Susana
Garcia Contreras, Consolación
Escudero Portugués, Rosa María
Isabel Redondo, Beatriz
Gonzalez Bulnes, Antonio
Óvilo, Cristina
author_role author
author2 Estellé, Jordi
Vázquez Gómez, Marta
López García, Adrián
Pesantez Pacheco, José Luis
Astiz, Susana
Garcia Contreras, Consolación
Escudero Portugués, Rosa María
Isabel Redondo, Beatriz
Gonzalez Bulnes, Antonio
Óvilo, Cristina
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.62
Microbiología (Veterinaria)
3109.05 Microbiología
topic 579.62
Microbiología (Veterinaria)
3109.05 Microbiología
description The gut microbiota of the pig is being increasingly studied due to its implications for host homeostasis and the importance of the pig as a meat source and biomedical model of human diseases. However, most studies comparing the microbiome between different breeds do not consider the influence of maternal environment during the colonization of the microbiota. The aim of the present study was to compare the gut microbiota during postnatal growth between two pig genotypes (purebred Iberian vs. crossbreds Iberian x Large White pigs), gestated in a single maternal environment (pure Iberian mothers) inseminated with heterospermic semen. Postnatally, piglets were maintained in the same environmental conditions, and their microbiota was studied at 60 and 210 days old. Results showed that age had the greatest influence on alpha and beta diversity, and genotype also affected beta diversity at both ages. There were differences in the microbiome profile between genotypes at the ASV and genus levels when jointly analyzing the total number of samples, which may help to explain phenotypical differences. When each time-point was analyzed individually, there were more differences at 210 days-old than 60 days-old. Fecal short-chain fatty acids (SCFA) were also affected by age, but not by genotype. These results may be a basis for further research on host genotype interactions with the gut microbiota
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-12-09
2024
2024-12-09
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/114002
url https://hdl.handle.net/20.500.14352/114002
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-108695RB-C31 EMPLEO DE ANTIOXIDANTES Y PUFA EN LA DIETA DE CERDAS IBERICAS PARA OPTIMIZAR LA HOMEOSTASIS METABOLICA E INTESTINAL Y LA PRODUCTIVIDAD DE LA DESCENDENCIA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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