Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort

Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations o...

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Autores: Cairat, Manon, Rinaldi, Sabina, Navionis, Anne-Sophie, Romieu, Isabelle, Biessy, Carine, Viallon, Vivian, Olsen, Anja, Tjønneland, Anne, Fournier, Agnès, Severi, Gianluca, Kvaskoff, Marina, Fortner, Renée T., Kaaks, Rudolf, Aleksandrova, Krasimira, Schulze, Matthias B., Masala, Giovanna, Tumino, Rosario, Sieri, Sabina, Grasso, Chiara, Mattiello, Amalia, Gram, Inger T., Olsen, Karina Standahl, Agudo, Antonio, Amiano Etxezarreta, Pilar, Sánchez, María José, Santiuste, Carmen, Barricarte, Aurelio, Monninkhof, Evelyn, Hiensch, Anouk E., Muller, David, Merritt, Melissa A., Travis, Ruth C., Weiderpass, Elisabete, Gunter, Marc J., Dossus, Laure
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/185249
Acesso em linha:https://hdl.handle.net/2445/185249
Access Level:acceso abierto
Palavra-chave:Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
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spelling Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohortCairat, ManonRinaldi, SabinaNavionis, Anne-SophieRomieu, IsabelleBiessy, CarineViallon, VivianOlsen, AnjaTjønneland, AnneFournier, AgnèsSeveri, GianlucaKvaskoff, MarinaFortner, Renée T.Kaaks, RudolfAleksandrova, KrasimiraSchulze, Matthias B.Masala, GiovannaTumino, RosarioSieri, SabinaGrasso, ChiaraMattiello, AmaliaGram, Inger T.Olsen, Karina StandahlAgudo, AntonioAmiano Etxezarreta, PilarSánchez, María José Santiuste, CarmenBarricarte, AurelioMonninkhof, EvelynHiensch, Anouk E.Muller, DavidMerritt, Melissa A.Travis, Ruth C.Weiderpass, ElisabeteGunter, Marc J.Dossus, LaureMarcadors bioquímicsCàncer de mamaBiochemical markersBreast cancerBackground Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.Springer Science and Business Media2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/185249Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/s12916-022-02319-yBMC Medicine, 2022https://doi.org/10.1186/s12916-022-02319-ycc by (c) Cairat, Manon et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1852492026-05-27T06:46:51Z
dc.title.none.fl_str_mv Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
title Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
spellingShingle Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
Cairat, Manon
Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
title_short Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
title_full Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
title_fullStr Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
title_full_unstemmed Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
title_sort Circulating inflammatory biomarkers, adipokines and breast cancer risk—a case-control study nested within the EPIC cohort
dc.creator.none.fl_str_mv Cairat, Manon
Rinaldi, Sabina
Navionis, Anne-Sophie
Romieu, Isabelle
Biessy, Carine
Viallon, Vivian
Olsen, Anja
Tjønneland, Anne
Fournier, Agnès
Severi, Gianluca
Kvaskoff, Marina
Fortner, Renée T.
Kaaks, Rudolf
Aleksandrova, Krasimira
Schulze, Matthias B.
Masala, Giovanna
Tumino, Rosario
Sieri, Sabina
Grasso, Chiara
Mattiello, Amalia
Gram, Inger T.
Olsen, Karina Standahl
Agudo, Antonio
Amiano Etxezarreta, Pilar
Sánchez, María José
Santiuste, Carmen
Barricarte, Aurelio
Monninkhof, Evelyn
Hiensch, Anouk E.
Muller, David
Merritt, Melissa A.
Travis, Ruth C.
Weiderpass, Elisabete
Gunter, Marc J.
Dossus, Laure
author Cairat, Manon
author_facet Cairat, Manon
Rinaldi, Sabina
Navionis, Anne-Sophie
Romieu, Isabelle
Biessy, Carine
Viallon, Vivian
Olsen, Anja
Tjønneland, Anne
Fournier, Agnès
Severi, Gianluca
Kvaskoff, Marina
Fortner, Renée T.
Kaaks, Rudolf
Aleksandrova, Krasimira
Schulze, Matthias B.
Masala, Giovanna
Tumino, Rosario
Sieri, Sabina
Grasso, Chiara
Mattiello, Amalia
Gram, Inger T.
Olsen, Karina Standahl
Agudo, Antonio
Amiano Etxezarreta, Pilar
Sánchez, María José
Santiuste, Carmen
Barricarte, Aurelio
Monninkhof, Evelyn
Hiensch, Anouk E.
Muller, David
Merritt, Melissa A.
Travis, Ruth C.
Weiderpass, Elisabete
Gunter, Marc J.
Dossus, Laure
author_role author
author2 Rinaldi, Sabina
Navionis, Anne-Sophie
Romieu, Isabelle
Biessy, Carine
Viallon, Vivian
Olsen, Anja
Tjønneland, Anne
Fournier, Agnès
Severi, Gianluca
Kvaskoff, Marina
Fortner, Renée T.
Kaaks, Rudolf
Aleksandrova, Krasimira
Schulze, Matthias B.
Masala, Giovanna
Tumino, Rosario
Sieri, Sabina
Grasso, Chiara
Mattiello, Amalia
Gram, Inger T.
Olsen, Karina Standahl
Agudo, Antonio
Amiano Etxezarreta, Pilar
Sánchez, María José
Santiuste, Carmen
Barricarte, Aurelio
Monninkhof, Evelyn
Hiensch, Anouk E.
Muller, David
Merritt, Melissa A.
Travis, Ruth C.
Weiderpass, Elisabete
Gunter, Marc J.
Dossus, Laure
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
topic Marcadors bioquímics
Càncer de mama
Biochemical markers
Breast cancer
description Background Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-alpha, interferon-gamma and 6 interleukins were associated with breast cancer risk, overall and by menopausal status. Methods Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration. Results Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)]. Conclusions Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/185249
url https://hdl.handle.net/2445/185249
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12916-022-02319-y
BMC Medicine, 2022
https://doi.org/10.1186/s12916-022-02319-y
dc.rights.none.fl_str_mv cc by (c) Cairat, Manon et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Cairat, Manon et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media
publisher.none.fl_str_mv Springer Science and Business Media
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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