Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector

Mitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the main cellular source of oxygen radicals, mitochondria have been postulated as the mediators of the cellular decline associated with the biol...

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Detalles Bibliográficos
Autores: Gómez, José, Mota-Martorell, Natália, Jové, Mariona, Pamplona, Reinald, Barja, Gustavo
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/30586
Acceso en línea:https://hdl.handle.net/10115/30586
Access Level:acceso abierto
Palabra clave:Animal longevity
Complex I
DNA damage
DNA fragments
Electron transport chain
NDUFV2 subunit
FeS N1a iron-sulfur cluster
Aging rate
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spelling Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effectorGómez, JoséMota-Martorell, NatáliaJové, MarionaPamplona, ReinaldBarja, GustavoAnimal longevityComplex IDNA damageDNA fragmentsElectron transport chainNDUFV2 subunitFeS N1a iron-sulfur clusterAging rateMitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the main cellular source of oxygen radicals, mitochondria have been postulated as the mediators of the cellular decline associated with the biological aging. Recent evidences have shown that mitochondrial free radical production is a highly regulated mechanism contributing to the biological determination of longevity which is species-specific. This mitochondrial free radical generation rate induces a diversity of adaptive responses and derived molecular damage to cell components, highlighting mitochondrial DNA damage, with biological consequences that influence the rate of aging of a given animal species. In this review, we explore the idea that mitochondria play a fundamental role in the determination of animal longevity. Once the basic mechanisms are discerned, molecular approaches to counter aging may be designed and developed to prevent or reverse functional decline, and to modify longevity.Elsevier202420242023info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/30586reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/305862026-06-24T12:48:17Z
dc.title.none.fl_str_mv Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
title Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
spellingShingle Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
Gómez, José
Animal longevity
Complex I
DNA damage
DNA fragments
Electron transport chain
NDUFV2 subunit
FeS N1a iron-sulfur cluster
Aging rate
title_short Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
title_full Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
title_fullStr Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
title_full_unstemmed Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
title_sort Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
dc.creator.none.fl_str_mv Gómez, José
Mota-Martorell, Natália
Jové, Mariona
Pamplona, Reinald
Barja, Gustavo
author Gómez, José
author_facet Gómez, José
Mota-Martorell, Natália
Jové, Mariona
Pamplona, Reinald
Barja, Gustavo
author_role author
author2 Mota-Martorell, Natália
Jové, Mariona
Pamplona, Reinald
Barja, Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Animal longevity
Complex I
DNA damage
DNA fragments
Electron transport chain
NDUFV2 subunit
FeS N1a iron-sulfur cluster
Aging rate
topic Animal longevity
Complex I
DNA damage
DNA fragments
Electron transport chain
NDUFV2 subunit
FeS N1a iron-sulfur cluster
Aging rate
description Mitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the main cellular source of oxygen radicals, mitochondria have been postulated as the mediators of the cellular decline associated with the biological aging. Recent evidences have shown that mitochondrial free radical production is a highly regulated mechanism contributing to the biological determination of longevity which is species-specific. This mitochondrial free radical generation rate induces a diversity of adaptive responses and derived molecular damage to cell components, highlighting mitochondrial DNA damage, with biological consequences that influence the rate of aging of a given animal species. In this review, we explore the idea that mitochondria play a fundamental role in the determination of animal longevity. Once the basic mechanisms are discerned, molecular approaches to counter aging may be designed and developed to prevent or reverse functional decline, and to modify longevity.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/30586
url https://hdl.handle.net/10115/30586
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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