Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors

Reproducció del document publicat a: https://doi.org/10.3390/bioengineering8060081

Detalles Bibliográficos
Autores: Llenas, Marina, Paoli, Roberto, Feiner Gràcia, Natalia, Albertazzi, Lorenzo, Samitier i Martí, Josep, Caballero Vila, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/182396
Acceso en línea:https://hdl.handle.net/2445/182396
https://doi.org/10.3390/bioengineering8060081
Access Level:acceso abierto
Palabra clave:Tumors
Vasos sanguinis
Blood vessels
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spelling Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular TumorsLlenas, MarinaPaoli, RobertoFeiner Gràcia, NataliaAlbertazzi, LorenzoSamitier i Martí, JosepCaballero Vila, DavidTumorsVasos sanguinisTumorsBlood vesselsReproducció del document publicat a: https://doi.org/10.3390/bioengineering8060081Tumor vessel-on-a-chip systems have attracted the interest of the cancer research community due to their ability to accurately recapitulate the multiple dynamic events of the metastatic cascade. Vessel-on-a-chip microfluidic platforms have been less utilized for investigating the distinctive features and functional heterogeneities of tumor-derived vascular networks. In particular, vascular tumors are characterized by the massive formation of thrombi and severe bleeding, a rare and life-threatening situation for which there are yet no clear therapeutic guidelines. This is mainly due to the lack of technological platforms capable of reproducing these characteristic traits of the pathology in a simple and well-controlled manner. Herein, we report the fabrication of a versatile tumor vessel-on-a-chip platform to reproduce, investigate, and characterize the massive formation of thrombi and hemorrhage on-chip in a fast and easy manner. Despite its simplicity, this method offers multiple advantages to recapitulate the pathophysiological events of vascular tumors, and therefore, may find useful applications in the field of vascular-related diseases, while at the same time being an alternative to more complex approaches.The authors acknowledge the support of CERCA Programme/Generalitat de Catalunya and the ICTS “NANBIOSIS” Nanotechnology Platform Unit of the CIBER in Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN) at the Institute for Bioengineering of Catalonia for assistance in the microfabrication. M. Funes, D. Izquierdo, S. Blackburn, and M. de Pablo (Nanobioengineering group—IBEC) are acknowledged for technical support.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/182396https://doi.org/10.3390/bioengineering8060081Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBioengineering, 2021, vol. 8, num. 6https://doi.org/10.3390/bioengineering8060081info:eu-repo/grantAgreement/EC/H2020/757397info:eu-repo/grantAgreement/EC/H2020/860436cc by (c) Llenas, Marina et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1823962026-05-29T05:05:01Z
dc.title.none.fl_str_mv Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
title Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
spellingShingle Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
Llenas, Marina
Tumors
Vasos sanguinis
Tumors
Blood vessels
title_short Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
title_full Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
title_fullStr Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
title_full_unstemmed Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
title_sort Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors
dc.creator.none.fl_str_mv Llenas, Marina
Paoli, Roberto
Feiner Gràcia, Natalia
Albertazzi, Lorenzo
Samitier i Martí, Josep
Caballero Vila, David
author Llenas, Marina
author_facet Llenas, Marina
Paoli, Roberto
Feiner Gràcia, Natalia
Albertazzi, Lorenzo
Samitier i Martí, Josep
Caballero Vila, David
author_role author
author2 Paoli, Roberto
Feiner Gràcia, Natalia
Albertazzi, Lorenzo
Samitier i Martí, Josep
Caballero Vila, David
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Tumors
Vasos sanguinis
Tumors
Blood vessels
topic Tumors
Vasos sanguinis
Tumors
Blood vessels
description Reproducció del document publicat a: https://doi.org/10.3390/bioengineering8060081
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/182396
https://doi.org/10.3390/bioengineering8060081
url https://hdl.handle.net/2445/182396
https://doi.org/10.3390/bioengineering8060081
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bioengineering, 2021, vol. 8, num. 6
https://doi.org/10.3390/bioengineering8060081
info:eu-repo/grantAgreement/EC/H2020/757397
info:eu-repo/grantAgreement/EC/H2020/860436
dc.rights.none.fl_str_mv cc by (c) Llenas, Marina et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Llenas, Marina et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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