Epigenomic characterization of circulating tumour cells in advanced colorectal cancer

Metastatic colorectal cancer continues to be a major health burden despite advances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers of the metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for d...

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Detalles Bibliográficos
Autor: Bao Caamaño, Aida
Tipo de recurso: tesis doctoral
Fecha de publicación:2023
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/30708
Acceso en línea:http://hdl.handle.net/10347/30708
Access Level:acceso abierto
Palabra clave:240701 Cultivo celular
241007 Genética humana
320713 Oncología
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spelling Epigenomic characterization of circulating tumour cells in advanced colorectal cancerBao Caamaño, Aida240701 Cultivo celular241007 Genética humana320713 OncologíaMetastatic colorectal cancer continues to be a major health burden despite advances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers of the metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for drug development and biomarkers to assess therapy response. In this frame, this thesis characterized the DNA methylome of CTCs in advanced colorectal cancer, providing new information about the biology of these cells and the metastatic process. This study also identified new potential therapeutic targets and epigenetic biomarkers that could help guide therapeutic decisions in patients with advanced disease, contributing to achieve a more personalized medicine in colorectal cancer.Díaz Lagares, ÁngelLópez López, RafaelUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20232023-01-0120232023-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/30708reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/307082026-06-15T12:47:27Z
dc.title.none.fl_str_mv Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
title Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
spellingShingle Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
Bao Caamaño, Aida
240701 Cultivo celular
241007 Genética humana
320713 Oncología
title_short Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
title_full Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
title_fullStr Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
title_full_unstemmed Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
title_sort Epigenomic characterization of circulating tumour cells in advanced colorectal cancer
dc.creator.none.fl_str_mv Bao Caamaño, Aida
author Bao Caamaño, Aida
author_facet Bao Caamaño, Aida
author_role author
dc.contributor.none.fl_str_mv Díaz Lagares, Ángel
López López, Rafael
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv 240701 Cultivo celular
241007 Genética humana
320713 Oncología
topic 240701 Cultivo celular
241007 Genética humana
320713 Oncología
description Metastatic colorectal cancer continues to be a major health burden despite advances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers of the metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for drug development and biomarkers to assess therapy response. In this frame, this thesis characterized the DNA methylome of CTCs in advanced colorectal cancer, providing new information about the biology of these cells and the metastatic process. This study also identified new potential therapeutic targets and epigenetic biomarkers that could help guide therapeutic decisions in patients with advanced disease, contributing to achieve a more personalized medicine in colorectal cancer.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/30708
url http://hdl.handle.net/10347/30708
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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