Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer

Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent gro...

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Autores: Arriba, María, Sánchez, Carmen, Vivas, Alfredo, Nutu, OA, Rueda, Daniel, Tapial, Sandra, Rodríguez, Yolanda, Brandáriz, Lorena, García, Juan L., García Olmo, Damián, Goel, Ajay, González-Sarmiento, Rogelio, Urioste, Miguel, Perea, José
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/691162
Acceso en línea:http://hdl.handle.net/10486/691162
https://dx.doi.org/10.1371/journal.pone.0216472
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Intermediate-onset
Clinicopathological
Polyps
Medicina
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spelling Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancerArriba, MaríaSánchez, CarmenVivas, AlfredoNutu, OARueda, DanielTapial, SandraRodríguez, YolandaBrandáriz, LorenaGarcía, Juan L.García Olmo, DamiánGoel, AjayGonzález-Sarmiento, RogelioUrioste, MiguelPerea, JoséColorectal cancerIntermediate-onsetClinicopathologicalPolypsMedicinaComparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.This work was funded by grants PI10/ 0683, PI13/0127 and PI16/01650 to J.P, PI16/ 01920 to R.G.S, and PI14/00459 to MU, from the Spanish Ministry of Health and Consumer Affairs, and cofunded by the European Regional Development Fund (FEDER); it was further supported by grants CA72851, CA181572 CA184792, CA187956 and CA202797 from the National Cancer Institute, National Institute of Health; RP140784 from the Cancer Prevention Research Institute of Texas; grants from the Sammons Cancer Center and Baylor Foundation, as well as funds from the Baylor Scott & White Research Institute, Dallas, TX, USA to AG.Public Library of ScienceDepartamento de CirugíaFacultad de Medicina20192019-04-16research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/691162https://dx.doi.org/10.1371/journal.pone.0216472reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6911622026-06-23T12:46:27Z
dc.title.none.fl_str_mv Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
spellingShingle Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
Arriba, María
Colorectal cancer
Intermediate-onset
Clinicopathological
Polyps
Medicina
title_short Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_full Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_fullStr Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_full_unstemmed Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
title_sort Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
dc.creator.none.fl_str_mv Arriba, María
Sánchez, Carmen
Vivas, Alfredo
Nutu, OA
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
Brandáriz, Lorena
García, Juan L.
García Olmo, Damián
Goel, Ajay
González-Sarmiento, Rogelio
Urioste, Miguel
Perea, José
author Arriba, María
author_facet Arriba, María
Sánchez, Carmen
Vivas, Alfredo
Nutu, OA
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
Brandáriz, Lorena
García, Juan L.
García Olmo, Damián
Goel, Ajay
González-Sarmiento, Rogelio
Urioste, Miguel
Perea, José
author_role author
author2 Sánchez, Carmen
Vivas, Alfredo
Nutu, OA
Rueda, Daniel
Tapial, Sandra
Rodríguez, Yolanda
Brandáriz, Lorena
García, Juan L.
García Olmo, Damián
Goel, Ajay
González-Sarmiento, Rogelio
Urioste, Miguel
Perea, José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Cirugía
Facultad de Medicina
dc.subject.none.fl_str_mv Colorectal cancer
Intermediate-onset
Clinicopathological
Polyps
Medicina
topic Colorectal cancer
Intermediate-onset
Clinicopathological
Polyps
Medicina
description Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-04-16
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/691162
https://dx.doi.org/10.1371/journal.pone.0216472
url http://hdl.handle.net/10486/691162
https://dx.doi.org/10.1371/journal.pone.0216472
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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