Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice

Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia that belongs to the sympathetic and parasympathetic ganglia. Most PCCs ar...

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Autores: Vaquero Susagna, Marta, Macià Armengol, Anna, Anerillas Aljama, Diego, Velasco Sánchez, Ana, Matias-Guiu, Xavier, Ribera i Calvet, Joan, Encinas Martín, Mario
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/59524
Acceso en línea:https://doi.org/10.1530/ERC-15-0585
http://hdl.handle.net/10459.1/59524
Access Level:acceso abierto
Palabra clave:Càncer
Cancer
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spelling Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- miceVaquero Susagna, MartaMacià Armengol, AnnaAnerillas Aljama, DiegoVelasco Sánchez, AnaMatias-Guiu, XavierRibera i Calvet, JoanEncinas Martín, MarioCàncerCancerPheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia that belongs to the sympathetic and parasympathetic ganglia. Most PCCs are sporadic but around 25%-30% of them are associated with familial syndromes caused by germline mutations of at least ten genes (Gimenez-Roqueplo et al. 2012). The low incidence of pheochromocytomas poses difficulties to the development of diagnostic or prognostic markers as well as effective therapies and thus the development of novel animal and cellular models for the study of the disease is needed. Sprouty family of genes is composed of four members of feedback inhibitors of receptor tyrosine kinase signaling, that specifically target the MAPK pathway. As such, they have been proposed as tumor suppressors in several cancerous pathologies such as tumors of the prostate, thyroid or liver (Masoumi-Moghaddam et al. 2014). Here we present a novel mouse model of pheochromocytoma consisting of double heterozygous mice for Pten and Spry1. These animals develop pheochromocytomas that appear at earlier onset and grow at higher rate than those from Pten+/- miceThis work was supported by grants from Ministerio de Economía y Competitividad (BFU2010-17628 and BFU2013-47175) to ME and funding from Suport als Grups de Recerca (2014 SGR 138) from Generalitat de Catalunya to ME and XM-G. MV is supported by a predoctoral fellowship from AGAUR (Generalitat de Catalunya). AM was supported by predoctoral fellowships from Universitat de Lleida and Fundació Alícia Cuello de Merigó. CA is supported by a predoctoral fellowship from Universitat de Lleida.Society for Endocrinology2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1530/ERC-15-0585http://hdl.handle.net/10459.1/59524reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMICINN/PN2008-2011/BFU2010-17628MINECO/PN2013-2016/BFU2013-47175Versió postprint del document publicat a: hhttps://doi.org/10.1530/ERC-15-0585Endocrine-Related Cancer, 2016, p. L7-L11(c) Society for Endocrinology, 2016info:eu-repo/semantics/openAccessoai:recercat.cat:10459.1/595242026-05-29T05:05:01Z
dc.title.none.fl_str_mv Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
title Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
spellingShingle Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
Vaquero Susagna, Marta
Càncer
Cancer
title_short Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
title_full Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
title_fullStr Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
title_full_unstemmed Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
title_sort Sprouty1 haploinsufficiency accelerates pheochromocytoma development in Pten+/- mice
dc.creator.none.fl_str_mv Vaquero Susagna, Marta
Macià Armengol, Anna
Anerillas Aljama, Diego
Velasco Sánchez, Ana
Matias-Guiu, Xavier
Ribera i Calvet, Joan
Encinas Martín, Mario
author Vaquero Susagna, Marta
author_facet Vaquero Susagna, Marta
Macià Armengol, Anna
Anerillas Aljama, Diego
Velasco Sánchez, Ana
Matias-Guiu, Xavier
Ribera i Calvet, Joan
Encinas Martín, Mario
author_role author
author2 Macià Armengol, Anna
Anerillas Aljama, Diego
Velasco Sánchez, Ana
Matias-Guiu, Xavier
Ribera i Calvet, Joan
Encinas Martín, Mario
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer
Cancer
topic Càncer
Cancer
description Pheochromocytomas (PCCs) are rare catecholamine-secreting tumors arising from the chromaffin cells in the adrenal medulla. Closely related paragangliomas share developmental origin but arise extra-adrenally, in the paraganglia that belongs to the sympathetic and parasympathetic ganglia. Most PCCs are sporadic but around 25%-30% of them are associated with familial syndromes caused by germline mutations of at least ten genes (Gimenez-Roqueplo et al. 2012). The low incidence of pheochromocytomas poses difficulties to the development of diagnostic or prognostic markers as well as effective therapies and thus the development of novel animal and cellular models for the study of the disease is needed. Sprouty family of genes is composed of four members of feedback inhibitors of receptor tyrosine kinase signaling, that specifically target the MAPK pathway. As such, they have been proposed as tumor suppressors in several cancerous pathologies such as tumors of the prostate, thyroid or liver (Masoumi-Moghaddam et al. 2014). Here we present a novel mouse model of pheochromocytoma consisting of double heterozygous mice for Pten and Spry1. These animals develop pheochromocytomas that appear at earlier onset and grow at higher rate than those from Pten+/- mice
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1530/ERC-15-0585
http://hdl.handle.net/10459.1/59524
url https://doi.org/10.1530/ERC-15-0585
http://hdl.handle.net/10459.1/59524
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv MICINN/PN2008-2011/BFU2010-17628
MINECO/PN2013-2016/BFU2013-47175
Versió postprint del document publicat a: hhttps://doi.org/10.1530/ERC-15-0585
Endocrine-Related Cancer, 2016, p. L7-L11
dc.rights.none.fl_str_mv (c) Society for Endocrinology, 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Society for Endocrinology, 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Society for Endocrinology
publisher.none.fl_str_mv Society for Endocrinology
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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