Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling

[EN] The development of magnetoactive microsystems for targeted drug delivery, magnetic biodetection, and replacement therapy is an important task of present day biomedical research. In this work, we experimentally studied the mechanical force acting in cylindrical ferrogel samples due to the applic...

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Autores: Blyakhman, Felix A., Safronov, Alexander P., Sokolov, Sergey Yu, Melnikov, Grigory Yu., Larrañaga Varga, Aitor, Kurlyandskaya, Galina V.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/57370
Acceso en línea:http://hdl.handle.net/10810/57370
Access Level:acceso abierto
Palabra clave:magnetic particles
ferrogels
biomimetic materials
magnetic field
attractive force
modeling
biomedical applications
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spelling Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and ModelingBlyakhman, Felix A.Safronov, Alexander P.Sokolov, Sergey YuMelnikov, Grigory Yu.Larrañaga Varga, AitorKurlyandskaya, Galina V.magnetic particlesferrogelsbiomimetic materialsmagnetic fieldattractive forcemodelingbiomedical applications[EN] The development of magnetoactive microsystems for targeted drug delivery, magnetic biodetection, and replacement therapy is an important task of present day biomedical research. In this work, we experimentally studied the mechanical force acting in cylindrical ferrogel samples due to the application of a non-uniform magnetic field. A commercial microsystem is not available for this type of experimental study. Therefore, the original experimental setup for measuring the mechanical force on ferrogel in a non-uniform magnetic field was designed, calibrated, and tested. An external magnetic field was provided by an electromagnet. The maximum intensity at the surface of the electromagnet was 39.8 kA/m and it linearly decreased within 10 mm distance from the magnet. The Ferrogel samples were based on a double networking polymeric structure which included a chemical network of polyacrylamide and a physical network of natural polysaccharide guar. Magnetite particles, 0.25 micron in diameter, were embedded in the hydrogel structure, up to 24% by weight. The forces of attraction between an electromagnet and cylindrical ferrogel samples, 9 mm in height and 13 mm in diameter, increased with field intensity and the concentration of magnetic particles, and varied within 0.1–30 mN. The model provided a fair evaluation of the mechanical forces that emerged in ferrogel samples placed in a non-uniform magnetic field and proved to be useful for predicting the deformation of ferrogels in practical bioengineering applications.This study was in part supported by the program of the Ministry of Health of the Russian Federation (project 121032300335-1). A.Yu. Zubarev and A.P. Safronov acknowledge the financial support of the Russian Science Foundation for theoretical modeling and the numerical verification of the model (grant 20-12-00031). This work was in part financially supported by (G.V. Kurlyandskaya and G.Yu. Melnikov) the Ministry of Science and Higher Education of the Russian Federation (grant number FEUZ-2020-0051).MDPI2022202220222022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/57370reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.mdpi.com/2072-666X/13/8/1165info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/© 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).oai:addi.ehu.eus:10810/573702026-06-18T09:23:17Z
dc.title.none.fl_str_mv Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
title Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
spellingShingle Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
Blyakhman, Felix A.
magnetic particles
ferrogels
biomimetic materials
magnetic field
attractive force
modeling
biomedical applications
title_short Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
title_full Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
title_fullStr Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
title_full_unstemmed Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
title_sort Mechanical Force Acting on Ferrogel in a Non-Uniform Magnetic Field: Measurements and Modeling
dc.creator.none.fl_str_mv Blyakhman, Felix A.
Safronov, Alexander P.
Sokolov, Sergey Yu
Melnikov, Grigory Yu.
Larrañaga Varga, Aitor
Kurlyandskaya, Galina V.
author Blyakhman, Felix A.
author_facet Blyakhman, Felix A.
Safronov, Alexander P.
Sokolov, Sergey Yu
Melnikov, Grigory Yu.
Larrañaga Varga, Aitor
Kurlyandskaya, Galina V.
author_role author
author2 Safronov, Alexander P.
Sokolov, Sergey Yu
Melnikov, Grigory Yu.
Larrañaga Varga, Aitor
Kurlyandskaya, Galina V.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv magnetic particles
ferrogels
biomimetic materials
magnetic field
attractive force
modeling
biomedical applications
topic magnetic particles
ferrogels
biomimetic materials
magnetic field
attractive force
modeling
biomedical applications
description [EN] The development of magnetoactive microsystems for targeted drug delivery, magnetic biodetection, and replacement therapy is an important task of present day biomedical research. In this work, we experimentally studied the mechanical force acting in cylindrical ferrogel samples due to the application of a non-uniform magnetic field. A commercial microsystem is not available for this type of experimental study. Therefore, the original experimental setup for measuring the mechanical force on ferrogel in a non-uniform magnetic field was designed, calibrated, and tested. An external magnetic field was provided by an electromagnet. The maximum intensity at the surface of the electromagnet was 39.8 kA/m and it linearly decreased within 10 mm distance from the magnet. The Ferrogel samples were based on a double networking polymeric structure which included a chemical network of polyacrylamide and a physical network of natural polysaccharide guar. Magnetite particles, 0.25 micron in diameter, were embedded in the hydrogel structure, up to 24% by weight. The forces of attraction between an electromagnet and cylindrical ferrogel samples, 9 mm in height and 13 mm in diameter, increased with field intensity and the concentration of magnetic particles, and varied within 0.1–30 mN. The model provided a fair evaluation of the mechanical forces that emerged in ferrogel samples placed in a non-uniform magnetic field and proved to be useful for predicting the deformation of ferrogels in practical bioengineering applications.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/57370
url http://hdl.handle.net/10810/57370
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2072-666X/13/8/1165
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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