Catheter-directed therapy for acute pulmonary embolism: results of a multicenter national registry

Introduction and objectives: Catheter -directed therapy (CDT) for acute pulmonary embolism (PE) is an emerging therapy that combines heterogeneous techniques. The aim of the study was to provide a nationwide contemporary snapshot of clinical practice and CDT -related outcomes. Methods: This Investig...

Descripción completa

Detalles Bibliográficos
Autores: Salinas, P, Vázquez-Alvarez, ME, Salvatella, N, Quevedo, VR, Martín, MV, Valero, E, Rumiz, E, Roman, Alfonso Jurado, Lozano, I, Gallardo, F, Amat-Santos, IJ, Lorenzo, O, Portero Portaz, Juan Jose, Huanca, M, Franco, Luis Nombela, Vaquerizo, B, Martínez, RR, Maneiro Melon, Nicolas Manuel, Sanchis, J, Berenguer, A, Lopez, Arsenio Gallardo, Ibanes, Enrique Gutierrez, Renteria, Hernan Mejia, Córdoba-Soriano, JG, Jiménez-Mazuecosn, JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17513
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17513
Access Level:acceso abierto
Palabra clave:Pulmonary embolism
Embolectomy
Thrombectomy
Thrombolytic therapy
Fibrinolytic therapy
Descripción
Sumario:Introduction and objectives: Catheter -directed therapy (CDT) for acute pulmonary embolism (PE) is an emerging therapy that combines heterogeneous techniques. The aim of the study was to provide a nationwide contemporary snapshot of clinical practice and CDT -related outcomes. Methods: This Investigator -initiated multicenter registry aimed to include consecutive patients with intermediate -high risk (IHR) or high -risk (HR), acute PE eligible for CDT. The primary outcome of the study was in -hospital all -cause death. Results: A total of 253 patients were included, of whom 93 (36.8%) had HR -PE, and 160 (63.2%) had IHRPE with a mean age of 62.3 +/- 15.1 years. Local thrombolysis was performed in 70.8% and aspiration thrombectomy in 51.8%, with 23.3% of patients receiving both. However, aspiration thrombectomy was favored in the HR -PE cohort (80.6% vs 35%; P < .001). Only 51 patients (20.2%) underwent CDT with specific PE devices. The success rate for CDT was 90.9% (98.1% of IHR-PE patients vs 78.5% of HR -PE patients, P < .001). In -hospital mortality was 15.5%, and was highly concentrated in the HR -PE patients (37.6%) and significantly lower in IHR-PE patients (2.5%), P < .001. Long-term (24 -month) mortality was 40.2% in HR -PE patients vs 8.2% in IHR-PE patients (P < .001). Conclusions: Despite the high success rate for CDT, in -hospital mortality in HR -PE is still high (37.6%) compared with very low IHR-PE mortality (2.5%). (c) 2023 Sociedad Espa & ntilde;ola de Cardiolog & iacute;a. Published by Elsevier Espa & ntilde;a, S.L.U. All rights reserved.

Similares en LA Referencia