Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures

Falgàs Martínez, Neus; Ruiz Peris, Mariona; Pérez Millan, Agnès; Sala Llonch, Roser; Antonell Boixader, Anna, 1978-; Balasa, Mircea; Borrego Écija, Sergi; Ramos Campoy, Oscar; Augé Fradera, Josep Maria; Castellví, Magdalena; Tort Merino, Adrià; Olives, Jaume; Fernández Villullas, Guadalupe; Blennow, Kaj; Zetterberg, Henrik; Bargalló Alabart, Núria; Lladó Plarrumaní, Albert; Sánchez del Valle Díaz, Raquel

Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures

Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship betwee...

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Authors:	Falgàs Martínez, Neus, Ruiz Peris, Mariona, Pérez Millan, Agnès, Sala Llonch, Roser, Antonell Boixader, Anna, 1978-, Balasa, Mircea, Borrego Écija, Sergi, Ramos Campoy, Oscar, Augé Fradera, Josep Maria, Castellví, Magdalena, Tort Merino, Adrià, Olives, Jaume, Fernández Villullas, Guadalupe, Blennow, Kaj, Zetterberg, Henrik, Bargalló Alabart, Núria, Lladó Plarrumaní, Albert, Sánchez del Valle Díaz, Raquel
Format:	article
Status:	Published version
Publication Date:	2020
Country:	España
Institution:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/176636
Online Access:	https://hdl.handle.net/2445/176636
Access Level:	Open access
Keyword:	Malaltia d'Alzheimer Degeneració Líquid cefalorraquidi Alzheimer's disease Degeneration Cerebrospinal fluid

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spelling	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signaturesFalgàs Martínez, NeusRuiz Peris, MarionaPérez Millan, AgnèsSala Llonch, RoserAntonell Boixader, Anna, 1978-Balasa, MirceaBorrego Écija, SergiRamos Campoy, OscarAugé Fradera, Josep MariaCastellví, MagdalenaTort Merino, AdriàOlives, JaumeFernández Villullas, GuadalupeBlennow, KajZetterberg, HenrikBargalló Alabart, NúriaLladó Plarrumaní, AlbertSánchez del Valle Díaz, RaquelMalaltia d'AlzheimerDegeneracióLíquid cefalorraquidiAlzheimer's diseaseDegenerationCerebrospinal fluidPrior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship between early‐onset AD (EOAD) and FTLD structural alterations and CSF biomarker levels. We included 138 subjects (64 EOAD, 26 FTLD, and 48 controls), all of them with a 3T MRI brain scan and CSF biomarkers available (the 42 amino acid‐long form of the amyloid‐beta protein [Aβ42], total‐tau protein [T‐tau], neurofilament light chain [NfL], neurogranin [Ng], and 14‐3‐3 levels). We used FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. We studied group differences in CTh and FA and described the "AD signature" and "FTLD signature." We tested multiple regression models to find which CSF‐biomarkers better explained each disease neuroimaging signature. CTh and FA maps corresponding to the AD and FTLD signatures were in accordance with previous literature. Multiple regression analyses showed that the biomarkers that better explained CTh values within the AD signature were Aβ and 14‐3‐3; whereas NfL and 14‐3‐3 levels explained CTh values within the FTLD signature. Similarly, NfL levels explained FA values in the FTLD signature. Ng levels were not predictive in any of the models. Biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.Wiley2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/176636Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/hbm.24925Human Brain Mapping, 2020, vol. 41, num. 8, p. 2004-2013https://doi.org/10.1002/hbm.24925info:eu-repo/grantAgreement/EC/H2020/681712cc by-nc (c) Falgàs Martínez, Neus et al., 2020http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1766362026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
title	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
spellingShingle	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures Falgàs Martínez, Neus Malaltia d'Alzheimer Degeneració Líquid cefalorraquidi Alzheimer's disease Degeneration Cerebrospinal fluid
title_short	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
title_full	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
title_fullStr	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
title_full_unstemmed	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
title_sort	Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
dc.creator.none.fl_str_mv	Falgàs Martínez, Neus Ruiz Peris, Mariona Pérez Millan, Agnès Sala Llonch, Roser Antonell Boixader, Anna, 1978- Balasa, Mircea Borrego Écija, Sergi Ramos Campoy, Oscar Augé Fradera, Josep Maria Castellví, Magdalena Tort Merino, Adrià Olives, Jaume Fernández Villullas, Guadalupe Blennow, Kaj Zetterberg, Henrik Bargalló Alabart, Núria Lladó Plarrumaní, Albert Sánchez del Valle Díaz, Raquel
author	Falgàs Martínez, Neus
author_facet	Falgàs Martínez, Neus Ruiz Peris, Mariona Pérez Millan, Agnès Sala Llonch, Roser Antonell Boixader, Anna, 1978- Balasa, Mircea Borrego Écija, Sergi Ramos Campoy, Oscar Augé Fradera, Josep Maria Castellví, Magdalena Tort Merino, Adrià Olives, Jaume Fernández Villullas, Guadalupe Blennow, Kaj Zetterberg, Henrik Bargalló Alabart, Núria Lladó Plarrumaní, Albert Sánchez del Valle Díaz, Raquel
author_role	author
author2	Ruiz Peris, Mariona Pérez Millan, Agnès Sala Llonch, Roser Antonell Boixader, Anna, 1978- Balasa, Mircea Borrego Écija, Sergi Ramos Campoy, Oscar Augé Fradera, Josep Maria Castellví, Magdalena Tort Merino, Adrià Olives, Jaume Fernández Villullas, Guadalupe Blennow, Kaj Zetterberg, Henrik Bargalló Alabart, Núria Lladó Plarrumaní, Albert Sánchez del Valle Díaz, Raquel
author2_role	author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Malaltia d'Alzheimer Degeneració Líquid cefalorraquidi Alzheimer's disease Degeneration Cerebrospinal fluid
topic	Malaltia d'Alzheimer Degeneració Líquid cefalorraquidi Alzheimer's disease Degeneration Cerebrospinal fluid
description	Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship between early‐onset AD (EOAD) and FTLD structural alterations and CSF biomarker levels. We included 138 subjects (64 EOAD, 26 FTLD, and 48 controls), all of them with a 3T MRI brain scan and CSF biomarkers available (the 42 amino acid‐long form of the amyloid‐beta protein [Aβ42], total‐tau protein [T‐tau], neurofilament light chain [NfL], neurogranin [Ng], and 14‐3‐3 levels). We used FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. We studied group differences in CTh and FA and described the "AD signature" and "FTLD signature." We tested multiple regression models to find which CSF‐biomarkers better explained each disease neuroimaging signature. CTh and FA maps corresponding to the AD and FTLD signatures were in accordance with previous literature. Multiple regression analyses showed that the biomarkers that better explained CTh values within the AD signature were Aβ and 14‐3‐3; whereas NfL and 14‐3‐3 levels explained CTh values within the FTLD signature. Similarly, NfL levels explained FA values in the FTLD signature. Ng levels were not predictive in any of the models. Biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.
publishDate	2020
dc.date.none.fl_str_mv	2020 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/176636
url	https://hdl.handle.net/2445/176636
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1002/hbm.24925 Human Brain Mapping, 2020, vol. 41, num. 8, p. 2004-2013 https://doi.org/10.1002/hbm.24925 info:eu-repo/grantAgreement/EC/H2020/681712
dc.rights.none.fl_str_mv	cc by-nc (c) Falgàs Martínez, Neus et al., 2020 http://creativecommons.org/licenses/by-nc/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by-nc (c) Falgàs Martínez, Neus et al., 2020 http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	10 p. application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	Articles publicats en revistes (Biomedicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures

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