Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial
This work was supported by the Spanish Ministry of Science, Innovation and Universities (PI12/01907); Spanish Network for Research in Infectious Diseases (RD16/0016/0005); Instituto de Salud Carlos III (ISCIII); and Spanish Ministry of Economy, Industry and Competitiveness. This work was also suppor...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12328/2666 |
| Acceso en línea: | http://hdl.handle.net/20.500.12328/2666 https://dx.doi.org/10.1093/cid/ciaa1081 |
| Access Level: | acceso abierto |
| Palabra clave: | Endocarditis Bacterièmia Daptomicina Fosfomicina Estafilococ aureus resistent a la meticil·lina Bacteriemia Estafilococo aureus resistente a la meticilina Bacteremia Daptomycin Fosfomycin Methicillin-resistant staphylococcus aureus 61 |
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| dc.title.none.fl_str_mv |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| title |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| spellingShingle |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial Pujol, Miquel Endocarditis Bacterièmia Daptomicina Fosfomicina Estafilococ aureus resistent a la meticil·lina Endocarditis Bacteriemia Daptomicina Fosfomicina Estafilococo aureus resistente a la meticilina Endocarditis Bacteremia Daptomycin Fosfomycin Methicillin-resistant staphylococcus aureus 61 |
| title_short |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| title_full |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| title_fullStr |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| title_full_unstemmed |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| title_sort |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trial |
| dc.creator.none.fl_str_mv |
Pujol, Miquel Miró, José-María Shaw, Evelyn Aguado, Jose-María San-Juan, Rafael Puig-Asensio, Mireia Pigrau, Carles Calbo Sebastián, Esther Montejo, Miguel Rodriguez-Álvarez, Regino Garcia-Pais, María-Jose Pintado, Vicente Escudero-Sánchez, Rosa Lopez-Contreras, Joaquín Morata, Laura Montero, Milagros Andrés, Marta Pasquau, Juan Arenas, María-del-Mar Padilla, Belén Murillas, Javier Jover-Sáenz, Alfredo López-Cortes, Luis-Eduardo García-Pardo, Graciano Gasch, Oriol Videla, Sebastian Hereu, Pilar Tebé, Cristian Pallarès, Natalia Sanllorente, Mireia Domínguez, María-Ángeles Càmara, Jordi Ferrer, Anna Padullés, Ariadna Cuervo, Guillermo Carratalà, Jordi MRSA Bacteremia (BACSARM) Trial Investigators |
| author |
Pujol, Miquel |
| author_facet |
Pujol, Miquel Miró, José-María Shaw, Evelyn Aguado, Jose-María San-Juan, Rafael Puig-Asensio, Mireia Pigrau, Carles Calbo Sebastián, Esther Montejo, Miguel Rodriguez-Álvarez, Regino Garcia-Pais, María-Jose Pintado, Vicente Escudero-Sánchez, Rosa Lopez-Contreras, Joaquín Morata, Laura Montero, Milagros Andrés, Marta Pasquau, Juan Arenas, María-del-Mar Padilla, Belén Murillas, Javier Jover-Sáenz, Alfredo López-Cortes, Luis-Eduardo García-Pardo, Graciano Gasch, Oriol Videla, Sebastian Hereu, Pilar Tebé, Cristian Pallarès, Natalia Sanllorente, Mireia Domínguez, María-Ángeles Càmara, Jordi Ferrer, Anna Padullés, Ariadna Cuervo, Guillermo Carratalà, Jordi MRSA Bacteremia (BACSARM) Trial Investigators |
| author_role |
author |
| author2 |
Miró, José-María Shaw, Evelyn Aguado, Jose-María San-Juan, Rafael Puig-Asensio, Mireia Pigrau, Carles Calbo Sebastián, Esther Montejo, Miguel Rodriguez-Álvarez, Regino Garcia-Pais, María-Jose Pintado, Vicente Escudero-Sánchez, Rosa Lopez-Contreras, Joaquín Morata, Laura Montero, Milagros Andrés, Marta Pasquau, Juan Arenas, María-del-Mar Padilla, Belén Murillas, Javier Jover-Sáenz, Alfredo López-Cortes, Luis-Eduardo García-Pardo, Graciano Gasch, Oriol Videla, Sebastian Hereu, Pilar Tebé, Cristian Pallarès, Natalia Sanllorente, Mireia Domínguez, María-Ángeles Càmara, Jordi Ferrer, Anna Padullés, Ariadna Cuervo, Guillermo Carratalà, Jordi MRSA Bacteremia (BACSARM) Trial Investigators |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Endocarditis Bacterièmia Daptomicina Fosfomicina Estafilococ aureus resistent a la meticil·lina Endocarditis Bacteriemia Daptomicina Fosfomicina Estafilococo aureus resistente a la meticilina Endocarditis Bacteremia Daptomycin Fosfomycin Methicillin-resistant staphylococcus aureus 61 |
| topic |
Endocarditis Bacterièmia Daptomicina Fosfomicina Estafilococ aureus resistent a la meticil·lina Endocarditis Bacteriemia Daptomicina Fosfomicina Estafilococo aureus resistente a la meticilina Endocarditis Bacteremia Daptomycin Fosfomycin Methicillin-resistant staphylococcus aureus 61 |
| description |
This work was supported by the Spanish Ministry of Science, Innovation and Universities (PI12/01907); Spanish Network for Research in Infectious Diseases (RD16/0016/0005); Instituto de Salud Carlos III (ISCIII); and Spanish Ministry of Economy, Industry and Competitiveness. This work was also supported by the European Development Regional Fund “A way to achieve Europe,” Operational Programme Intelligent Growth 2014–2020; Spanish Clinical Research Network (SCReN), co-financed by the Plan Nacional de I+D and ISCIII, Subdirección General de Evaluación y Fomento de la Investigación (PT13/0002/0007); and the Grupo de Estudio de la Infección Relacionada con la Asistencia Sanitaria. J. M.-M. received a personal 80:20 research grant from the Institut d’Investigacions Biomèdiques Agust Pi i Sunyer, Barcelona, Spain, during 2017–2021. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12328/2666 https://dx.doi.org/10.1093/cid/ciaa1081 |
| url |
http://hdl.handle.net/20.500.12328/2666 https://dx.doi.org/10.1093/cid/ciaa1081 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Clinical Infectious Diseases 72;9 |
| dc.rights.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
9 |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
| publisher.none.fl_str_mv |
Oxford University Press |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869403249896849408 |
| spelling |
Daptomycin plus fosfomycin versus daptomycin alone for methicillin-resistant staphylococcus aureus bacteremia and endocarditis: a randomized clinical trialPujol, MiquelMiró, José-MaríaShaw, EvelynAguado, Jose-MaríaSan-Juan, RafaelPuig-Asensio, MireiaPigrau, CarlesCalbo Sebastián, EstherMontejo, MiguelRodriguez-Álvarez, ReginoGarcia-Pais, María-JosePintado, VicenteEscudero-Sánchez, RosaLopez-Contreras, JoaquínMorata, LauraMontero, MilagrosAndrés, MartaPasquau, JuanArenas, María-del-MarPadilla, BelénMurillas, JavierJover-Sáenz, AlfredoLópez-Cortes, Luis-EduardoGarcía-Pardo, GracianoGasch, OriolVidela, SebastianHereu, PilarTebé, CristianPallarès, NataliaSanllorente, MireiaDomínguez, María-ÁngelesCàmara, JordiFerrer, AnnaPadullés, AriadnaCuervo, GuillermoCarratalà, JordiMRSA Bacteremia (BACSARM) Trial InvestigatorsEndocarditisBacterièmiaDaptomicinaFosfomicinaEstafilococ aureus resistent a la meticil·linaEndocarditisBacteriemiaDaptomicinaFosfomicinaEstafilococo aureus resistente a la meticilinaEndocarditisBacteremiaDaptomycinFosfomycinMethicillin-resistant staphylococcus aureus61This work was supported by the Spanish Ministry of Science, Innovation and Universities (PI12/01907); Spanish Network for Research in Infectious Diseases (RD16/0016/0005); Instituto de Salud Carlos III (ISCIII); and Spanish Ministry of Economy, Industry and Competitiveness. This work was also supported by the European Development Regional Fund “A way to achieve Europe,” Operational Programme Intelligent Growth 2014–2020; Spanish Clinical Research Network (SCReN), co-financed by the Plan Nacional de I+D and ISCIII, Subdirección General de Evaluación y Fomento de la Investigación (PT13/0002/0007); and the Grupo de Estudio de la Infección Relacionada con la Asistencia Sanitaria. J. M.-M. received a personal 80:20 research grant from the Institut d’Investigacions Biomèdiques Agust Pi i Sunyer, Barcelona, Spain, during 2017–2021.Background: We aimed to determine whether daptomycin plus fosfomycin provides higher treatment success than daptomycin alone for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and endocarditis. Methods: A randomized (1:1) phase 3 superiority, open-label, and parallel group clinical trial of adult inpatients with MRSA bacteremia was conducted at 18 Spanish hospitals. Patients were randomly assigned to receive either 10 mg/kg of daptomycin intravenously daily plus 2 g of fosfomycin intravenously every 6 hours, or 10 mg/kg of daptomycin intravenously daily. Primary endpoint was treatment success 6 weeks after the end of therapy. Results: Of 167 patients randomized, 155 completed the trial and were assessed for the primary endpoint. Treatment success at 6 weeks after the end of therapy was achieved in 40 of 74 patients who received daptomycin plus fosfomycin and in 34 of 81 patients who were given daptomycin alone (54.1% vs 42.0%; relative risk, 1.29 [95% confidence interval, .93–1.8]; P = .135). At 6 weeks, daptomycin plus fosfomycin was associated with lower microbiologic failure (0 vs 9 patients; P = .003) and lower complicated bacteremia (16.2% vs 32.1%; P = .022). Adverse events leading to treatment discontinuation occurred in 13 of 74 patients (17.6%) receiving daptomycin plus fosfomycin, and in 4 of 81 patients (4.9%) receiving daptomycin alone (P = .018). Conclusions: Daptomycin plus fosfomycin provided 12% higher rate of treatment success than daptomycin alone, but this difference did not reach statistical significance. This antibiotic combination prevented microbiological failure and complicated bacteremia, but it was more often associated with adverse events.info:eu-repo/semantics/publishedVersionOxford University Press2020info:eu-repo/semantics/article9http://hdl.handle.net/20.500.12328/2666https://dx.doi.org/10.1093/cid/ciaa1081reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésClinical Infectious Diseases72;9This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/26662026-05-29T05:05:01Z |
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15,811543 |