Hepatitis C prevalence in injecting drug users in Europe, 1990-2007: impact of study recruitment setting

Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multileve...

Descripción completa

Detalles Bibliográficos
Autores: Rondy, M, Wiessing, L, Hutchinson, S J, Matheï, C, Mathis, F, Mravcik, V, Norden, L, Rosińska, M, Scutelniciuc, O, Suligoi, B, Vallejo-Ruiz de Leon, Fernando, Van Veen, M, Kretzschmar, M
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11500
Acceso en línea:http://hdl.handle.net/20.500.12105/11500
Access Level:acceso abierto
Palabra clave:Needle-Exchange Programs
Patient Selection
Substance Abuse Treatment Centers
Adult
Europe
Female
Hepatitis C
Humans
Male
Prevalence
Research Design
Selection Bias
Seroepidemiologic Studies
Substance Abuse, Intravenous
Descripción
Sumario:Monitoring injecting drug users' (IDUs) health is challenging because IDUs form a difficult to reach population. We examined the impact of recruitment setting on hepatitis C prevalence. Individual datasets from 12 studies were merged. Predictors of HCV positivity were sought through a multilevel analysis using a mixed-effects logistic model, with study identifier as random intercept. HCV prevalence ranged from 21% to 86% across the studies. Overall, HCV prevalence was higher in IDUs recruited in drug treatment centres compared to those recruited in low-threshold settings (74% and 42%, respectively, P < 0·001). Recruitment setting remained significantly associated with HCV prevalence after adjustment for duration of injecting and recent injection (adjusted odds ratio 0·7, 95% confidence interval 0·6-0·8, P = 0·05). Recruitment setting may have an impact on HCV prevalence estimates of IDUs in Europe. Assessing the impact of mixed recruitment strategies, including respondent-driven sampling, on HCV prevalence estimates, would be valuable.

Similares en LA Referencia