Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.

Species A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated t...

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Detalles Bibliográficos
Autores: Navarro-Lleó, Noemi, Aznar-Córdoba, Silvia, Asensio-Cob, Dunia, Luque, Daniel, Rodríguez, Javier M, Gozalbo-Rovira, Roberto, Alcaraz-Soriano, María Jesús, Cárcamo-Calvo, Roberto, Rodríguez-Díaz, Jesús, Buesa, Javier
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:dnet:repisalud__::9f7611063281a11f300fcdb5907e052c
Acceso en línea:https://hdl.handle.net/20.500.12105/27457
Access Level:acceso abierto
Palabra clave:VP2
VP6
Antibodies
Non‐A rotaviruses
Seroepidemiology
Adolescent
Adult
Aged
Antibodies, Viral
Child
Child, Preschool
Female
Gastroenteritis
Humans
Infant
Infant, Newborn
Male
Middle Aged
Rotavirus Infections
Rotavirus
Seroepidemiologic Studies
Spain
Young Adult
Descripción
Sumario:Species A rotavirus (RVA) is a major cause of acute gastroenteritis in children. However, three other rotavirus species (RVB, RVC, and RVH) are also able to infect humans. It has been suggested that vaccination against RVA could facilitate an increase of non-A rotavirus infections. We investigated the antibody prevalence against RVA, RVB, RVC, and RVH in 420 human sera collected between 2020 and 2022 from different age groups in Valencia (Spain). Antibody prevalence rates to RVA, RVB, RVC, and RVH were 79.3%, 17.9%, 18.8%, and 14.5%, respectively. Antibody titers against RVA remained consistent across the different age groups, and RVB showed low titers except in younger individuals. RVC-specific antibodies peaked in children 5-10 years of age, whereas RVH exhibited the highest titers in the elderly. The detection of antibodies against non-A rotaviruses in humans in Spain, for the first time against RVB and RVH, highlights the need for their surveillance.

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