Influenza vaccine effectiveness in reducing severe outcomes over six influenza seasons, a case-case analysis, Spain, 2010/11 to 2015/16

When influenza vaccination is ineffective in preventing influenza virus infection, it may still reduce the severity of influenza-associated disease. Here, we estimate the effect of influenza vaccination in preventing severe outcomes e.g. intensive care unit (ICU) admission and death, even thougHospi...

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Autores: Godoy, Pere|||0000-0002-2896-7286, Romero, Arantxa, Soldevila, Núria|||0000-0002-1353-5325, Torner, Nuria|||0000-0003-0143-5295, Jané i Checa, Mireia|||0000-0002-1302-6723, Martínez, Ana, Domínguez, Ángela|||0000-0003-0219-1907, Alsedà, Miquel|||0000-0003-4008-3616, Álvarez, Josep, Arias, César, Balaña, Pilar Jorgina, Barrabeig, Irene|||0000-0003-4789-7620, Camps, Neus, Carol Torrades, Monica, Ferràs, J., Ferrús, Glòria, Follia, Núria, Bach Foradada, Pilar, Minguell, Sofia, Parrón, Ignacio|||0000-0002-4875-0236, Plasència, Elsa, Sala-Farré, Maria Rosa, Torra Bastardas, Roser, Torres, J., Caylà, Joan A.|||0000-0003-3891-111X, Gorrindo, Pilar, Rius i Gibert, Maria Cristina|||0000-0001-5189-6503, Marcos, María Ángeles|||0000-0002-5019-4873, Mosquera, Maria del Mar|||0000-0001-5863-7424, Vilella, Anna|||0000-0002-2329-676X, Antón Pagarolas, Andrés, 1976-|||0000-0002-1476-0815, Pumarola Suñé, Tomàs|||0000-0002-5171-7461, Campins Martí, Magda|||0000-0002-8841-6195, Garciá, D., Espejo, Elena|||0000-0001-9018-7515, Freixas, Núria, Riera Garcia, Montserrat, Maraver, Encarna, Mas, Dolors, Perez, Rafael, Rebull Fatsini, Josep|||0000-0002-1460-8290, Pou, J., García-Pardo, Graciano|||0000-0003-0274-6001, Olona, Montserrat|||0000-0001-5303-9361, Barcenilla, Fernando, Castellana, Dolors, Navarro Rubio, Gemma|||0000-0002-7195-9046, Force, Lluís
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:287818
Acceso en línea:https://ddd.uab.cat/record/287818
https://dx.doi.org/urn:doi:10.2807/1560-7917.ES.2018.23.43.1700732
Access Level:acceso abierto
Palabra clave:Disease severity
Hospitalised patients
Influenza
Spain
Vaccine effectiveness
Descripción
Sumario:When influenza vaccination is ineffective in preventing influenza virus infection, it may still reduce the severity of influenza-associated disease. Here, we estimate the effect of influenza vaccination in preventing severe outcomes e.g. intensive care unit (ICU) admission and death, even thougHospital it did not prevent influenza virus infection and subsequent hospitalisation. An observational case-case epidemiological study was carried out in 12 sentinel hospitals in Catalonia (Spain) over six influenza seasons 2010/11-2015/16. Cases were individuals witHospital severe laboratory-confirmed influenza virus infection and aged 18 years and older. For eacHospital reported case we collected demographic, virological and clinical characteristics. Logistic regression was used to estimate the crude, adjusted odd ratios (aOR) and 95% confidence intervals (CI). Of 1,727 hospital-ised patients included in the study, 799 were female (46.7%), 591 (34.2%) were admitted to the ICU and 223 (12.9%) died. Influenza vaccination uptake was lower in cases that required ICU admission or died (21.2% vs 29.7%, p < 0.001). The adjusted influenza vaccination effectiveness in preventing ICU admission or deatHospital was 23% (95% CI: 1 to 40). In an analysis restricted to sex, age group and antiviral treatment, influenza vaccination had a positive effect on disease severity in all age groups and categories. We found that influenza vaccination reduced the severity of disease even in cases where it did not prevent infection and influenza-associated hospitalisation. Therefore, increased vaccination uptake may reduce complications, ICU admission and death.

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